Children's working understanding of knowledge sources : confidence in knowledge gained from testimony

In three experiments children aged between 3 and 5 years (N = 38; 52; 94; mean ages 3;7 to 5;2) indicated their confidence in their knowledge of the identity of a hidden toy. With the exception of some 3-year-olds, children revealed working understanding of their knowledge source by showing high confidence when they had seen or felt the toy, and lower confidence when they had been told its identity by an apparently well-informed speaker, especially when the speaker subsequently doubted the adequacy of his access to the toy. After a 2-minute delay, 3-to 4- year olds, unlike 4- to 5-year-olds, failed to see the implications of the speaker’s doubt about his access

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

CONTAINING REFORM: THE UK STANCE ON THE EUROPEAN COMMUNITY ElA DIRECTIVE

After a decade's deliberation, the European Community EIA Directive bccomes operative on July 3, 1988. Member states spent 7 years refining the proposals and were given 3 years to devise implementation procedures. In this paper the attempt by the UK government to contain the impact of the Directive on domestic policy is reviewed. While the UK government was successful in eroding many provisions during formulation, it has been prevented from exempting many projects from mandatory EIA in its im- plementation procedures. The most significant reform is that many projects are subject to formal EIA for the first time. Copyright 1988 by The Policy Studies Organization.