1,097 research outputs found
The application of local hypobaric pressure â A novel means to enhance macromolecule entry into the skin
AbstractThe local application of controlled hypobaric stress represents a novel means to facilitate drug delivery into the skin. The aims of this work were to understand how hypobaric stress modified the properties of the skin and assess if this penetration enhancement strategy could improve the percutaneous penetration of a macromolecule. Measurements of skin thickness demonstrated that the topical application of hypobaric stress thinned the tissue (p<0.05), atomic force microscopy showed that it shrunk the corneocytes in the stratum corneum (p<0.001) and the imaging of the skin hair follicles using multiphoton microscopy showed that it opened the follicular infundibula (p<0.001). Together, these changes contributed to a 19.6-fold increase in in vitro percutaneous penetration of a 10,000 molecular weight dextran molecule, which was shown using fluorescence microscopy to be localized around the hair follicles, when applied to the skin using hypobaric stress. In vivo, in the rat, a local hemodynamic response (i.e. a significant increase in blood flow, p<0.001) was shown to contribute to the increase in follicular transport of the dextran to produce a systemic absorption of 7.2±2.81fg·mLâ1. When hypobaric stress was not applied to the rat there was no detectable absorption of dextran and this provided evidence that this novel penetration enhancement technique can improve the percutaneous penetration of macromolecules after topical application to the skin
Validity of Generalized Second Law of Thermodynamics in the Logamediate and Intermediate scenarios of the Universe
In this work, we have investigated the validity of the generalized second law
of thermodynamics in logamediate and intermediate scenarios of the universe
bounded by the Hubble, apparent, particle and event horizons using and without
using first law of thermodynamics. We have observed that the GSL is valid for
Hubble, apparent, particle and event horizons of the universe in the
logamediate scenario of the universe using first law and without using first
law. Similarly the GSL is valid for all horizons in the intermediate scenario
of the universe using first law. Also in the intermediate scenario of the
universe, the GSL is valid for Hubble, apparent and particle horizons but it
breaks down whenever we consider the universe enveloped by the event horizon
Charged rotating dilaton black branes in AdS universe
We present the metric for the -dimensional charged rotating dilaton
black branes with cylindrical or toroidal horizons in the background of anti-de
Sitter spacetime. We find the suitable counterterm which removes the
divergences of the action in the presence of the dilaton potential in all
higher dimensions. We plot the Penrose diagrams of the spacetime and reveal
that the spacetime geometry crucially modifies in the presence of the dilaton
field. The conserved and thermodynamic quantities of the black branes are also
computed.Comment: 13 pages, 3 figures, to appear in Gen. Relat. Gravi
Two-Component Fluid Membranes Near Repulsive Walls: Linearized Hydrodynamics of Equilibrium and Non-equilibrium States
We study the linearized hydrodynamics of a two-component fluid membrane near
a repulsive wall, via a model which incorporates curvature- concentration
coupling as well as hydrodynamic interactions. This model is a simplified
version of a recently proposed one [J.-B. Manneville et al. Phys. Rev. E, 64,
021908 (2001)] for non-equilibrium force-centres embedded in fluid membranes,
such as light-activated bacteriorhodopsin pumps incorporated in phospholipid
(EPC) bilayers. The pump/membrane system is modeled as an impermeable,
two-component bilayer fluid membrane in the presence of an ambient solvent, in
which one component, representing active pumps, is described in terms of force
dipoles displaced with respect to the bilayer midpoint. We first discuss the
case in which such pumps are rendered inactive, computing the mode structure in
the bulk as well as the modification of hydrodynamic properties by the presence
of a nearby wall. We then discuss the fluctuations and mode structure in steady
state of active two-component membranes near a repulsive wall. We find that
proximity to the wall smoothens membrane height fluctuations in the stable
regime, resulting in a logarithmic scaling of the roughness even for initially
tensionless membranes. This explicitly non-equilibrium result, a consequence of
the incorporation of curvature-concentration coupling in our treatment, also
indicates that earlier scaling arguments which obtained an increase in the
roughness of active membranes near repulsive walls may need to be reevaluated.Comment: 39 page Latex file, 3 encapsulated Postscript figure
Thermodynamics of higher dimensional topological charged AdS black branes in dilaton gravity
In this paper, we study topological AdS black branes of -dimensional
Einstein-Maxwell-dilaton theory and investigate their properties. We use the
area law, surface gravity and Gauss law interpretations to find entropy,
temperature and electrical charge, respectively. We also employ the modified
Brown and York subtraction method to calculate the quasilocal mass of the
solutions. We obtain a Smarr-type formula for the mass as a function of the
entropy and the charge, compute the temperature and the electric potential
through the Smarr-type formula and show that these thermodynamic quantities
coincide with their values which are calculated through using the geometry.
Finally, we perform a stability analysis in the canonical ensemble and
investigate the effects of the dilaton field and the size of black brane on the
thermal stability of the solutions. We find that large black branes are stable
but for small black brane, depending on the value of dilaton field and type of
horizon, we encounter with some unstable phases.Comment: 21 pages, 21 figures, references updated, minor editing, accepted in
EPJC (DOI: 10.1140/epjc/s10052-010-1483-3
The transitional gap transient AT 2018hso: new insights into the luminous red nova phenomenon
Context. The absolute magnitudes of luminous red novae (LRNe) are intermediate between those of novae and supernovae (SNe), and show a relatively homogeneous spectro-photometric evolution. Although they were thought to derive from core instabilities in single stars, there is growing support for the idea that they are triggered by binary interaction that possibly ends with the merging of the two stars.
Aims. AT 2018hso is a new transient showing transitional properties between those of LRNe and the class of intermediate-luminosity red transients (ILRTs) similar to SN 2008S. Through the detailed analysis of the observed parameters, our study supports that it actually belongs to the LRN class and was likely produced by the coalescence of two massive stars.
Methods. We obtained ten months of optical and near-infrared photometric monitoring, and 11 epochs of low-resolution optical spectroscopy of AT 2018hso. We compared its observed properties with those of other ILRTs and LRNe. We also inspected the archival Hubble Space Telescope (HST) images obtained about 15 years ago to constrain the progenitor properties.
Results. The light curves of AT 2018hso show a first sharp peak (reddening-corrected M-r = -13.93 mag), followed by a broader and shallower second peak that resembles a plateau in the optical bands. The spectra dramatically change with time. Early-time spectra show prominent Balmer emission lines and a weak [Ca II] doublet, which is usually observed in ILRTs. However, the strong decrease in the continuum temperature, the appearance of narrow metal absorption lines, the great change in the H alpha strength and profile, and the emergence of molecular bands support an LRN classification. The possible detection of a M-I similar to -8 mag source at the position of AT 2018hso in HST archive images is consistent with expectations for a pre-merger massive binary, similar to the precursor of the 2015 LRN in M101.
Conclusions. We provide reasonable arguments to support an LRN classification for AT 2018hso. This study reveals growing heterogeneity in the observables of LRNe than has been thought previously, which is a challenge for distinguishing between LRNe and ILRTs. This suggests that the entire evolution of gap transients needs to be monitored to avoid misclassifications
High-throughput field imaging and basic image analysis in a wheat breeding programme
Visual assessment of colour-based traits plays a key role within field-crop breeding programmes, though the process is subjective and time-consuming. Digital image analysis has previously been investigated as an objective alternative to visual assessment for a limited number of traits, showing suitability and slight improvement to throughput over visual assessment. However, easily adoptable, field-based high-throughput methods are still lacking. The aim of the current study was to produce a high-throughput digital imaging and analysis pipeline for the assessment of colour-based traits within a wheat breeding programme. This was achieved through the steps of (i) a proof-of-concept study demonstrating basic image analysis methods in a greenhouse, (ii) application of these methods to field trials using hand-held imaging, and (iii) developing a field-based high-throughput imaging infrastructure for data collection. The proof of concept study showed a strong correlation (r = 0.95) between visual and digital assessments of wheat physiological yellowing (PY) in a greenhouse environment, with both scores having similar heritability (H2 = 0.85 and 0.76, respectively). Digital assessment of hand-held field images showed strong correlations to visual scores for PY (r = 0.61 and 0.78), senescence (r = 0.74 and 0.75) and Septoria tritici blotch (STB; r = 0.76), with greater heritability of digital scores, excluding STB. Development of the high-throughput imaging infrastructure allowed for images of field plots to be collected at a rate of 7,400 plots per hour. Images of an advanced breeding trial collected with this system were analysed for canopy cover at two time-points, with digital scores correlating strongly to visual scores (r = 0.88 and 0.86) and having similar or greater heritability. This study details how high-throughput digital phenotyping can be applied to colour-based traits within field trials of a wheat breeding programme. It discusses the logistics of implementing such systems with minimal disruption to the programme, provides a detailed methodology for the basic image analysis methods utilized, and has potential for application to other field-crop breeding or research programmes.James Walter, James Edwards, Jinhai Cai, Glenn McDonald, Stanley J. Miklavcic, and Haydn Kuche
Non-Extremal D-instantons and the AdS/CFT Correspondence
We investigate non-extremal D-instantons in an asymptotically background and the role they play in the correspondence.
We find that the holographic dual operators of non-extremal D-instanton
configurations do not correspond to self-dual Yang-Mills instantons, and we
compute explicitly the deviation from self-duality. Furthermore, a class of
non-extremal D-instantons yield Euclidean axionic wormhole solutions with two
asymptotic boundaries. After Wick rotating, this provides a playground for
investigating holography in the presence of cosmological singularities in a
closed universe.Comment: 30 pages, 3 figure
The Glauber model and the heavy ion reaction cross section
We reexamine the Glauber model and calculate the total reaction cross section
as a function of energy in the low and intermediate energy range, where many of
the corrections in the model, are effective.
The most significant effect in this energy range is by the modification of
the trajectory due to the Coulomb field. The modification in the trajectory due
to nuclear field is also taken into account in a self consistent way.
The energy ranges in which particular corrections are effective, are
quantified and it is found that when the center of mass energy of the system
becomes 30 times the Coulomb barrier, none of the trajectory modification to
the Glauber model is really required.
The reaction cross sections for light and heavy systems, right from near
coulomb barrier to intermediate energies have been calculated. The exact
nuclear densities and free nucleon-nucleon (NN) cross sections have been used
in the calculations. The center of mass correction which is important for light
systems, has also been taken into account.
There is an excellent agreement between the calculations with the modified
Glauber model and the experimental data. This suggests that the heavy ion
reactions in this energy range can be explained by the Glauber model in terms
of free NN cross sections without incorporating any medium modification.Comment: RevTeX, 21 pages including 9 Postscript figures, submitted to Phys.
Rev.
Four-fermion interaction from torsion as dark energy
The observed small, positive cosmological constant may originate from a
four-fermion interaction generated by the spin-torsion coupling in the
Einstein-Cartan-Sciama-Kibble gravity if the fermions are condensing. In
particular, such a condensation occurs for quark fields during the
quark-gluon/hadron phase transition in the early Universe. We study how the
torsion-induced four-fermion interaction is affected by adding two terms to the
Dirac Lagrangian density: the parity-violating pseudoscalar density dual to the
curvature tensor and a spinor-bilinear scalar density which measures the
nonminimal coupling of fermions to torsion.Comment: 6 pages; published versio
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