QCD Chiral restoration at finite TT under the Magnetic field: Studies based on the instanton vacuum model

We investigate the chiral restoration at finite temperature $(T)$ under the strong external magnetic field $\vec{B}=B_{0}\hat{z}$ of the SU(2) light-flavor QCD matter. We employ the instanton-liquid QCD vacuum configuration accompanied with the linear Schwinger method for inducing the magnetic field. The Harrington-Shepard caloron solution is used to modify the instanton parameters, i.e. the average instanton size $(\bar{\rho})$ and inter-instanton distance $(\bar{R})$, as functions of $T$. In addition, we include the meson-loop corrections (MLC) as the large-$N_{c}$ corrections because they are critical for reproducing the universal chiral restoration pattern. We present the numerical results for the constituent-quark mass as well as chiral condensate which signal the spontaneous breakdown of chiral-symmetry (SB$\chi$S), as functions of $T$ and $B$. Besides we find that the changes for the $F_\pi$ and $m_\pi$ due to the magnetic field is relatively small, in comparison to those caused by the finite $T$ effect.Comment: 4 pages, 1 table, 6figs. arXiv admin note: significant text overlap with arXiv:1103.605

Creep behavior of copper-chromium in-situ composite

Creep deformation and fracture behaviors were investigated on a deformation-processed Cu-Cr in-situ composite over a temperature range of 200 °C to 650 °C. It was found that the creep resistance increases significantly with the introduction of Cr fibers into Cu. The stress exponent and the activation energy for creep of the composite at high temperatures (≥400 °C) were observed to be 5.5 and 180 to 216 kJ/mol, respectively. The observation that the stress exponent and the activation energy for creep of the composite at high temperatures (≥400 °C) are close to those of pure Cu suggests that the creep deformation of the composite is dominated by the deformation of the Cu matrix. The high stress exponent at low temperatures (200 °C and 300 °C) is thought be associated with the as-swaged microstructure, which contains elongated dislocation cells and subgrains that are stable and act as strong athermal obstacles at low temperatures. The mechanism of damage was found to be similar for all the creep tests performed, but the distribution and extent of damage were found to be very sensitive to the test temperature

Field and angular dependence of the Sommerfeld coefficient in Al-doped MgB2 single crystals

International audienceThe angular and field dependence of the Sommerfeld coefficient = lim Cel /T T→0 Cel being the electronic contribution to the specific heat has been measured in Al-doped MgB2 single crystals for x=0, x=0.1, and x 0.2 . We show that the decomposition previously introduced to describe H, where is the angle between the applied field and the c axis in pure samples Phys. Rev. Lett. 98, 137001 2007 is well adapted to doped samples: e.g., the contribution of the band to the specific heat is proportional to B/Bc2 whereas the contribution of the band is isotropic but highly nonlinear in field. We hence present the evolution of the coherence lengths of the two bands and corresponding Fermi velocities with doping

AC Microcalorimetry of Superconducting MgCNi3 Single Crystals

Proceedings of the CSMAG'07 Conference, Kosice, July 9-12, 2007International audienceThe low-temperature speci¯c heat of single-crystal samples of super- conducting MgCNi3 with typical dimensions 200 ¹m were measured for the ¯rst time. A computer controlled ac microcalorimeter using an optical ¯ber and an infrared light-emitting diode as the heat source was used down to 2 K at magnetic ¯elds up to 8 T. The speci¯c heat data suggest a moderate coupling in MgCNi3

The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole

Gain-of-function variants in voltage-gated sodium channel NaV1.7 that increase firing frequency and spontaneous firing of dorsal root ganglion (DRG) neurons have recently been identified in 5-10% of patients with idiopathic small fiber neuropathy (I-SFN). Our previous in vitro observations suggest that enhanced sodium channel activity can contribute to a decrease in length of peripheral sensory axons. We have hypothesized that sustained sodium influx due to the expression of SFN-associated sodium channel variants may trigger an energetic deficit in neurons that contributes to degeneration and loss of nerve fibers in SFN. Using an ATP FRET biosensor, we now demonstrate reduced steady-state levels of ATP and markedly faster ATP decay in response to membrane depolarization in cultured DRG neurons expressing an SFN-associated variant NaV1.7, I228M, compared with wild-type neurons. We also observed that I228M neurons show a significant reduction in mitochondrial density and size, indicating dysfunctional mitochondria and a reduced bioenergetic capacity. Finally, we report that exposure to dexpramipexole, a drug that improves mitochondrial energy metabolism, increases the neurite length of I228M-expressing neurons. Our data suggest that expression of gain-of-function variants of NaV1.7 can damage mitochondria and compromise cellular capacity for ATP production. The resulting bioenergetic crisis can consequently contribute to loss of axons in SFN. We suggest that, in addition to interventions that reduce ionic disturbance caused by mutant NaV1.7 channels, an alternative therapeutic strategy might target the bioenergetic burden and mitochondrial damage that occur in SFN associated with NaV1.7 gain-of-function mutations.NEW & NOTEWORTHY Sodium channel NaV1.7 mutations that increase dorsal root ganglion (DRG) neuron excitability have been identified in small fiber neuropathy (SFN). We demonstrate reduced steady-state ATP levels, faster depolarization-evoked ATP decay, and reduced mitochondrial density and size in cultured DRG neurons expressing SFN-associated variant NaV1.7 I228M. Dexpramipexole, which improves mitochondrial energy metabolism, has a protective effect. Because gain-of-function NaV1.7 variants can compromise bioenergetics, therapeutic strategies that target bioenergetic burden and mitochondrial damage merit study in SFN

How strong can the coupling of leptonic photons be?

Consequences of possible existence of leptonic photon are considered for a range of values of leptonic charge. In the case of a strong Coulomb-like leptonic repulsion between electrons the existence of ordinary condensed matter is impossible: antineutrinos cannot neutralize this destructive repulsion. The upper limit of leptonic charge is inferred from the E\"{o}tv\"os type experiments. If however there exist light stable scalar bosons with leptonic charge (e.g. singlet antisneutrinos) they may neutralize the electron repulsion. Possible experimental manifestations of such leptonic bosons in gases and condensed matter are briefly discussed.Comment: 13 pages in standard LaTe

Geometrical barriers and lower critical field in MgB2 single crystals

International audienceThe first penetration field sHpd has been deduced from local magnetization and specific heat measurements in magnesium diboride single crystals. For Ha ic, the geometrical barriers (GB) play a dominant role in the irreversibility mechanism. In thin samples, neglecting the GB in this direction would then lead to a large overestimation of Hc1 deduced from Hp through the standard elliptical formula. The lower critical field is found to be isotropic at low temperature (0.11±0.01 T)

Quantitation of angiogenesis in vitro induced by VEGF-A and FGF-2 in two different human endothelial cultures : an all-in-one assay

Angiogenic therapy is considered to be a promising tool for treatment of ischemic diseases. Many in vivo and in vitro assays have been developed to identify potential proangiogenic drugs and to investigate their mode of action. However, until now no validated system exists that would allow quantitation of angiogenesis in vitro in only one assay. Here, a previously established all-in-one in vitro assay based on staging of the angiogenic cascade was validated by quantitation of the effects of the known proangiogenic factors VEGF-A and FGF-2. Both growth factors were applied separately or in combination to human endothelial cell cultures derived from the heart and the foreskin, and angiogenesis was quantitated over 30 days of culture. Additionally, gene expression of VEGFR-1, VEGFR-2 and FGFR-1 at 3, 10, 20 or 40 days of cultivation was quantitated by RT-qPCR. In both cultures, VEGF-A as well as FGF-2 induced a run through all defined stages of angiogenesis in vitro. Application of VEGF-A only led to formation of irregular globular endothelial structures, while FGF-2 resulted in development of regular capillary-like structures. Quantitation of the angiogenic effects of VEGF-A and transcripts of VEGFR-1 and VEGFR-2 showed that a high VEGFR-1/VEGFR-2 ratio evoked deceleration of angiogenesis

Robust paramagnetism in Bi2-xMxRu2O7 (M=Mn,Fe,Co,Ni,Cu) pyrochlore

We report physical property characterization of Bi2-xMxRu2O7 pyrochlores, including magnetic suseptibility, resistivity, and Seebeck coefficients. The solid solution exists up to x=0.5 for (M=Cu,Ni,Co) and up to x=0.1 for (M=Fe,Mn). None of the doped materials exhibit ferromagnetism or any localized ruthenium moment behavior. Instead we find the Ru-O and Bi-O sublattices to be essentially independent, with any magnetism resulting from the unpaired transition metal dopant spins. Cobalt substitution for bismuth results in localized Co{2+}, and low temperature spin-glass transitions in several cases. Nickel moments on the pyrochlore lattice display properties intermediate to localized and itinerant. Finally, copper doping results in only an enhancement of the Pauli metallic density of states.Comment: submitted, Phys. Rev.

Living in the twilight zone:A qualitative study on the experiences of patients with advanced cancer obtaining long-term response to immunotherapy or targeted therapy

Purpose The introduction of immunotherapy and targeted therapy has drastically improved the life expectancy of patients with advanced cancer. Despite improved survival, obtaining long-term response can be highly distressing and comes with uncertainties that affect several life domains. The aim of this study is to gain a deeper understanding of long-term responders’ lived experiences with obtaining long-term response to immunotherapy or targeted therapy. Methods We conducted an exploratory qualitative study using thematic data analysis. Semi-structured in-depth interviews were conducted with 17 patients with advanced melanoma or lung cancer who had a confirmed response to or long-term stable disease while on immunotherapy or targeted therapy. Results Long-term responders are living in a twilight zone, where they neither feel like a patient, nor feel healthy. This impacts their self-image, interactions with their social environment, and feelings of uncertainty. Due to their uncertain life perspective, long-term responders are going back and forth between hope and despair, while they are longing for their ‘old’ life, several barriers, such as protective behavior of the social environment, force them to adjust to a life with cancer. Conclusion Long-term responders are facing many challenges, such as searching for a renewed identity, dealing with ongoing uncertainty, and having to adapt to a new normal. This emphasizes the importance of providing this new patient group with tailored information and support