1,018 research outputs found
PO-0659: Impact of 68Ga-Dotatoc-PET on tumor delineation and outcome in patients with meningioma
Langevin Simulations of Two Dimensional Vortex Fluctuations: Anomalous Dynamics and a New -exponent
The dynamics of two dimensional (2D) vortex fluctuations are investigated
through simulations of the 2D Coulomb gas model in which vortices are
represented by soft disks with logarithmic interactions. The simulations
trongly support a recent suggestion that 2D vortex fluctuations obey an
intrinsic anomalous dynamics manifested in a long range 1/t-tail in the vortex
correlations. A new non-linear IV-exponent a, which is different from the
commonly used AHNS exponent, a_AHNS and is given by a = 2a_AHNS - 3, is
confirmed by the simulations. The results are discussed in the context of
earlier simulations, experiments and a phenomenological description.Comment: Submitted to PRB, RevTeX format, 28 pages and 13 figures, figures in
postscript format are available at http://www.tp.umu.se/~holmlund/papers.htm
Future Fire Impacts on Smoke Concentrations, Visibility, and Health in the Contiguous United States
Fine particulate matter (PM2.5) from U.S. anthropogenic sources is decreasing. However,
previous studies have predicted that PM2.5 emissions from wildfires will increase in the midcentury to next
century, potentially offsetting improvements gained by continued reductions in anthropogenic emissions.
Therefore, some regions could experience worse air quality, degraded visibility, and increases in
population-level exposure. We use global climate model simulations to estimate the impacts of changing fire
emissions on air quality, visibility, and premature deaths in the middle and late 21st century. We find that
PM2.5 concentrations will decrease overall in the contiguous United States (CONUS) due to decreasing
anthropogenic emissions (total PM2.5 decreases by 3% in Representative Concentration Pathway [RCP] 8.5
and 34% in RCP4.5 by 2100), but increasing fire-related PM2.5 (fire-related PM2.5 increases by 55% in RCP4.5
and 190% in RCP8.5 by 2100) offsets these benefits and causes increases in total PM2.5 in some regions.
We predict that the average visibility will improve across the CONUS, but fire-related PM2.5 will reduce
visibility on the worst days in western and southeastern U.S. regions. We estimate that the number of deaths
attributable to total PM2.5 will decrease in both the RCP4.5 and RCP8.5 scenarios (from 6% to 4â5%), but
the absolute number of premature deaths attributable to fire-related PM2.5 will double compared to early
21st century. We provide the first estimates of future smoke health and visibility impacts using a
prognostic land-fire model. Our results suggest the importance of using realistic fire emissions in future air
quality projections
Continuation-Passing C: compiling threads to events through continuations
In this paper, we introduce Continuation Passing C (CPC), a programming
language for concurrent systems in which native and cooperative threads are
unified and presented to the programmer as a single abstraction. The CPC
compiler uses a compilation technique, based on the CPS transform, that yields
efficient code and an extremely lightweight representation for contexts. We
provide a proof of the correctness of our compilation scheme. We show in
particular that lambda-lifting, a common compilation technique for functional
languages, is also correct in an imperative language like C, under some
conditions enforced by the CPC compiler. The current CPC compiler is mature
enough to write substantial programs such as Hekate, a highly concurrent
BitTorrent seeder. Our benchmark results show that CPC is as efficient, while
using significantly less space, as the most efficient thread libraries
available.Comment: Higher-Order and Symbolic Computation (2012). arXiv admin note:
substantial text overlap with arXiv:1202.324
Shear-banding in a lyotropic lamellar phase, Part 1: Time-averaged velocity profiles
Using velocity profile measurements based on dynamic light scattering and
coupled to structural and rheological measurements in a Couette cell, we
present evidences for a shear-banding scenario in the shear flow of the onion
texture of a lyotropic lamellar phase. Time-averaged measurements clearly show
the presence of structural shear-banding in the vicinity of a shear-induced
transition, associated to the nucleation and growth of a highly sheared band in
the flow. Our experiments also reveal the presence of slip at the walls of the
Couette cell. Using a simple mechanical approach, we demonstrate that our data
confirms the classical assumption of the shear-banding picture, in which the
interface between bands lies at a given stress . We also outline
the presence of large temporal fluctuations of the flow field, which are the
subject of the second part of this paper [Salmon {\it et al.}, submitted to
Phys. Rev. E]
A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity
Many Gram-positive bacteria produce lipoteichoic acid (LTA) polymers whose physiological roles have remained a matter of debate because of the lack of LTA-deficient mutants. The ypfP gene responsible for biosynthesis of a glycolipid found in LTA was deleted in Staphylococcus aureus SA113, causing 87% reduction of the LTA content. Mass spectrometry and nuclear magnetic resonance spectroscopy revealed that the mutant LTA contained a diacylglycerol anchor instead of the glycolipid, whereas the remaining part was similar to the wild-type polymer except that it was shorter. The LTA mutant strain revealed no major changes in patterns of cell wall proteins or autolytic enzymes compared with the parental strain indicating that LTA may be less important in S. aureus protein attachment than previously thought. However, the autolytic activity of the mutant was strongly reduced demonstrating a role of LTA in controlling autolysin activity. Moreover, the hydrophobicity of the LTA mutant was altered and its ability to form biofilms on plastic was completely abrogated indicating a profound impact of LTA on physicochemical properties of bacterial surfaces. We propose to consider LTA and its biosynthetic enzymes as targets for new antibiofilm strategies
Crucial Physical Dependencies of the Core-Collapse Supernova Mechanism
We explore with self-consistent 2D F{\sc{ornax}} simulations the dependence
of the outcome of collapse on many-body corrections to neutrino-nucleon cross
sections, the nucleon-nucleon bremsstrahlung rate, electron capture on heavy
nuclei, pre-collapse seed perturbations, and inelastic neutrino-electron and
neutrino-nucleon scattering. Importantly, proximity to criticality amplifies
the role of even small changes in the neutrino-matter couplings, and such
changes can together add to produce outsized effects. When close to the
critical condition the cumulative result of a few small effects (including
seeds) that individually have only modest consequence can convert an anemic
into a robust explosion, or even a dud into a blast. Such sensitivity is not
seen in one dimension and may explain the apparent heterogeneity in the
outcomes of detailed simulations performed internationally. A natural
conclusion is that the different groups collectively are closer to a realistic
understanding of the mechanism of core-collapse supernovae than might have
seemed apparent.Comment: 25 pages; 10 figure
Epidermal RAF prevents allergic skin disease
The RAS pathway is central to epidermal homeostasis, and its activation in tumors or in Rasopathies correlates with hyperproliferation. Downstream of RAS, RAF kinases are actionable targets regulating keratinocyte turnover; however, chemical RAF inhibitors paradoxically activate the pathway, promoting epidermal proliferation. We generated mice with compound epidermis restricted BRAF/RAF1 ablation. In these animals, transient barrier defects and production of chemokines and Th2-type cytokines by keratinocytes cause a disease akin to human atopic dermatitis, characterized by IgE responses and local and systemic inflammation. Mechanistically, BRAF and RAF1 operate independently to balance MAPK signaling: BRAF promotes ERK activation, while RAF1 dims stress kinase activation. In vivo, JNK inhibition prevents disease onset, while MEK/ERK inhibition in mice lacking epidermal RAF1 phenocopies it. These results support a primary role of keratinocytes in the pathogenesis of atopic dermatitis, and the animals lacking BRAF and RAF1 in the epidermis represent a useful model for this disease
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