Local and non-local approaches to fatigue crack initiation and propogation

Copyright @ 2003 Kulwer Academic Publishers.A functional form of local strength conditions under fatigue loading is introduced and employed to formulation and analysis of fatigue crack initiation and propagation. For the strength conditions associated with the Palmgren-Miner linear damage accumulation rule and the power-type S-N diagram, the problem is reduced to a non-linear integral Volterra equation, which can be transformed to a linear one for the case of a single crack. An analytical solution of some simple problems are presented for the latter case and shortcomings of the local approach are pointed out. A non-local approach free from the shortcomings is presented along with an example of its implementation.This work was completed under the research grant GR/M24592 "Non-local approach to high cyclic fatigue: Theoretical basis" of the Engineering and Physical Sciences Research Council, UK

Non-alcoholic fatty liver disease: relationship with cardiovascular risk markers and clinical endpoints

Non-alcoholic fatty liver disease (NAFLD) is a common diagnosis and is increasing in prevalence worldwide. NAFLD is usually asymptomatic at presentation; progression of the disease is unpredictable, leading to the development of a variety of techniques for screening, diagnosis and risk stratification. Clinical methods in current use include serum biomarker panels, hepatic ultrasound, magnetic resonance imaging, and liver biopsy. NAFLD is strongly associated with the metabolic syndrome, and the most common cause of death for people with the condition is cardiovascular disease. Whether NAFLD is an independent cardiovascular risk factor needs exploration. NAFLD has been associated with surrogate markers of cardiovascular disease such as carotid intima-media thickness, the presence of carotid plaque, brachial artery vasodilatory responsiveness and CT coronary artery calcification score. There is no effective medical treatment for NAFLD and evidence is lacking regarding the efficacy of interventions in mitigating cardiovascular risk. Health care professionals managing patients with NAFLD should tackle the issue with early identification of risk factors and aggressive modification. Current management strategies therefore comprise lifestyle change,with close attention to known cardiovascular risk factors

Optimum Placement of Post-1PN GW Chirp Templates Made Simple at any Match Level via Tanaka-Tagoshi Coordinates

A simple recipe is given for constructing a maximally sparse regular lattice of spin-free post-1PN gravitational wave chirp templates subject to a given minimal match constraint, using Tanaka-Tagoshi coordinates.Comment: submitted to Phys. Rev.

The Effective Action in Gauged Supergravity on Hyperbolic Background and Induced Cosmological Constant

The one-loop effective action for 4-dimensional gauged supergravity with negative cosmological constant, is investigated in space-times with compact hyperbolic spatial section. The explicit expansion of the effective action as a power series of the curvature on hyperbolic background is derived, making use of heat-kernel and zeta-regularization techniques. The induced cosmological and Newton constants are computed.Comment: 9 pages, UTF 23

Cardinal characteristics at in a small u (κ) model

We provide a model where u(κ)<2κu(κ)<2κ for a supercompact cardinal κ. [10] provides a sketch of how to obtain such a model by modifying the construction in [6]. We provide here a complete proof using a different modification of [6] and further study the values of other natural generalizations of classical cardinal characteristics in our model. For this purpose we generalize some standard facts that hold in the countable case as well as some classical forcing notions and their properties

A Theory for the Conformal Factor in Quantum R2R^2 Gravity

A new theory for the conformal factor in R$^2$-gravity is developed. The infrared phase of this theory, which follows from the one-loop renormalization group equations for the whole quantum R$^2$-gravity theory is described. The one-loop effective potential for the conformal factor is found explicitly and a mechanism for inducing Einstein gravity at the minimum of the effective potential for the conformal factor is suggested. A comparison with the effective theory of the conformal factor induced by the conformal anomaly, and also aiming to describe quantum gravity at large distances, is done.Comment: 10 pages, LaTeX file, June 1-199

Indestructibility of Vopenka's Principle

We show that Vopenka's Principle and Vopenka cardinals are indestructible under reverse Easton forcing iterations of increasingly directed-closed partial orders, without the need for any preparatory forcing. As a consequence, we are able to prove the relative consistency of these large cardinal axioms with a variety of statements known to be independent of ZFC, such as the generalised continuum hypothesis, the existence of a definable well-order of the universe, and the existence of morasses at many cardinals.Comment: 15 pages, submitted to Israel Journal of Mathematic

A bound on 6D N=1 supergravities

We prove that there are only finitely many distinct semi-simple gauge groups and matter representations possible in consistent 6D chiral (1,0) supergravity theories with one tensor multiplet. The proof relies only on features of the low-energy theory; the consistency conditions we impose are that anomalies should be cancelled by the Green-Schwarz mechanism, and that the kinetic terms for all fields should be positive in some region of moduli space. This result does not apply to the case of the non-chiral (1,1) supergravities, which are not constrained by anomaly cancellation.Comment: 23 pages, no figures; two paragraphs added to the proof in Appendix A covering the SU(2) and SU(3) case, other minor correction

Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement

CONTEXT: Existing data regarding the association between growth hormone deficiency (GHD) and liver fat content are conflicting. OBJECTIVE: We aimed i) to assess intrahepatocellular lipid (IHCL) content in hypopituitary adults with GHD compared to matched controls and ii) to evaluate the effect of growth hormone (GH) replacement on IHCL content. DESIGN: Cross-sectional comparison and controlled intervention study. PATIENTS, PARTICIPANTS: Cross-sectional comparison: 22 hypopituitary adults with GHD and 44 healthy controls matched for age, BMI, gender and ethnicity. Intervention study: 9 GHD patients starting GH replacement (GH Rx group), 9 GHD patients not starting replacement therapy (non-GH Rx group). INTERVENTION: Intervention study:GH replacement for 6 months in the GH Rx group, dosage was titrated to achieve normal IGF-1 levels. MAIN OUTCOME MEASURES: IHCL content determined by proton magnetic resonance spectroscopy (1 H MRS). RESULTS: Cross-sectional comparison: There was no difference in IHCL content between GHD patients and healthy controls (1.89% (0.30, 4.03) vs. 1.14% (0.22, 2.32); p=0.2), the prevalence of patients with hepatic steatosis (IHCL of ≥ 5.56%) was similar in the two groups (22.7% vs. 15.9%; chi square probability = 0.4). Intervention study: The change in IHCL content over 6 months did not differ between the GH Rx group and the non-GH Rx group (-0.63 ± 4.53% vs. +0.11 ± 1.46%; p=0.6). CONCLUSIONS: In our study liver fat content and the prevalence of hepatic steatosis did not differ between hypopituitary adults with GHD and matched controls. In GHD patients GH replacement had no effect on liver fat content