Criopreservação de protozoários dos gêneros trichomonas donne, 1837 e tritrichomonas kafoid, 1920

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Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar

Bis-Triazolylidenes of Manganese and Rhenium and Their Catalytic Application in N-Alkylation of Amines with Alcohols

Funding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT) for Projects PTDC/QUI-QIN/0359/2021, MOSTMICRO-ITQB, UIDB/04612/20220, and UIPD/04612/2020 and Ph.D. Fellowship SFRH/BD/131955/2017 (S.F.). The National NMR Facility is supported by CERMAX through Project 022162. The authors also thank C. Almeida for elemental analysis at ITQB laboratories. For the X-ray diffraction studies, C.S.B.G. thanks FCT for Projects LAQV (UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020), UCIBIO (UIDB/04378/2020 and UIDP/04378/2020), and i4HB (LA/P/0140/2020). Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.A new family of air-stable Mn and Re complexes bearing bidentate bis(1,2,3-triazol-5-ylidene) ligands with the general formula [M(bis-triazolylidene)(CO)3X] (M = Mn or Re; X = Cl or Br), containing a methylene linker or a direct link between the two triazolylidene ligands, is presented. All complexes have been applied as catalysts for the N-alkylation of anilines with benzylic alcohols. The Mn complex bearing a bis-triazolylidene with a methylene bridge between the two triazolylidene fragments was shown to be a highly efficient catalyst, affording the corresponding amine in 92% yield in the presence of a low base loading (t-BuOK, 0.1 equiv). Comparison between Mn complexes bearing imidazolium- and triazolium-derived N-heterocyclic carbene ligands showed that Mn triazolylidenes displayed higher catalytic activity when a low base loading was used.publishersversionpublishe

Lumpy Skin Disease Is Characterized by Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection.

Lumpy skin disease is a high-consequence disease in cattle caused by infection with the poxvirus lumpy skin disease virus (LSDV). The virus is endemic in most countries in Africa and an emerging threat to cattle populations in Europe and Asia. As LSDV spreads into new regions, it is important that signs of disease are recognized promptly by animal caregivers. This study describes the gross, microscopic, and ultrastructural changes that occur over time in cattle experimentally challenged with LSDV. Four calves were inoculated with wildtype LSDV and monitored for 19 to 21 days. At 7 days after inoculation, 2 of the 4 cattle developed multifocal cutaneous nodules characteristic of LSD. Some lesions displayed a targetoid appearance. Histologically, intercellular and intracellular edema was present in the epidermis of some nodules. Occasional intracytoplasmic inclusion bodies were identified in keratinocytes. More severe and consistent changes were present in the dermis, with marked histiocytic inflammation and necrotizing fibrinoid vasculitis of dermal vessels, particularly the deep dermal plexus. Chronic lesions consisted of full-thickness necrosis of the dermis and epidermis. Lesions in other body organs were not a major feature of LSD in this study, highlighting the strong cutaneous tropism of this virus. Immunohistochemistry and electron microscopy identified LSDV-infected histiocytes and fibroblasts in the skin nodules of affected cattle. This study highlights the noteworthy lesions of LSDV and how they develop over&nbsp;time.</p

Criopreservação de protozoários dos gêneros trichomonas donne, 1837 e tritrichomonas kafoid, 1920

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Fixed Points and Zeros for Set Valued Mappings on Riemannian Manifolds: A Subdifferential Approach

In this paper we establish several results which allow to find fixed points and zeros of set-valued mappings on Riemannian manifolds. In order to prove these results we make use of subdifferential calculus. We also give some useful applications

School bullying by one or more ways : does it matter and how do students cope?

Students (n=452; ages 12–14 years) attending two South Australian metropolitan high schools completed the ‘Living & learning at school: Bullying at school’ survey in which they reported ways they were bullied and the strategies they would use to deal with bullying. Results showed that a small proportion of students were bullied in three or more ways, and that males and females differed in the coping strategies they would use if bullied. Significant differences were found between bullied and not bullied students in their use of ‘problem-focused’ in contrast to ‘emotion focused’, or ‘approach’ in contrast to ‘avoidance’ coping strategies, with bullied students more likely to use ‘avoidance’ strategies. Findings suggest that in terms of coping, it does matter whether or not a student is bullied in multiple ways

Analgesia e ação antiinflamatória da Arnica montana 12CH comparativamente ao cetoprofeno em cães Analgesic and anti-inflammatory effects of Arnica montana 12CH in comparison with ketoprofen in dogs

Objetivou-se avaliar os efeitos analgésico e antiinflamatório da Arnica montana 12CH comparativamente ao cetoprofeno em cadelas submetidas à ovariossalpingohisterectomia (OSH). Foram avaliadas 16 cadelas, distribuídas aleatoriamente em dois grupos de oito animais cada, tratados por via oral com 1mg kg-1 de cetoprofeno (TC) e com cinco glóbulos de Arnica montana 12CH (TA). Decorridos 60 minutos, os animais foram tranquilizados com acepromazina (0,05mg kg-1, IV), seguindo-se indução e manutenção anestésica com propofol (5mg kg-1, IV) e isofluorano, respectivamente. Foram mensurados: frequência cardíaca, frequência respiratória, pressão arterial sistólica, concentração final expirada de dióxido de carbono, concentração final expirada de isofluorano, variáveis hemogasométricas, concentração sérica de cortisol, grau de analgesia e de inflamação. Em casos de analgesia insuficiente, foi realizada suplementação com morfina (0,5mg kg-1, IM). A estatística foi realizada com ANOVA e teste de Tukey (P<0,05). Estabilidade cardiorrespiratória foi observada em ambos os tratamentos durante a OSH. Não houve diferença entre os tratamentos em relação ao grau de analgesia e de inflamação. Analgesia de resgate foi necessária em dois animais de cada grupo. Conclui-se que a Arnica montana 12 CH confere efeitos analgésico e antiinflamatório semelhantes aos do cetoprofeno, sendo uma opção segura e efetiva para cadelas submetidas à OSH.<br>This study aimed to evaluate the analgesic and anti-inflammatory effects of Arnica montana 12CH comparatively to ketoprofen in dogs undergoing ovariohysterectomy. Sixteen female dogs were randomly distributed in two groups of eight animals and received 1mg kg-1 of ketoprofen (TC) and 5 globules of Arnica montana 12CH (TA) by oral route. After 60 minutes, the dogs were sedated with acepromazine (0.05mg kg-1, IV), followed by anesthetic induction with propofol (5mg kg-1 IV) and maintained with isoflurane. Heart rate, respiratory rate, systolic blood pressure, arterial blood gases, serum cortisol concentration and degree of analgesia and inflammation were measured. Additional morphine (0.5mg kg-1IM) was given when the analgesia was insufficient. Statistical analyses were performed by ANOVA and Tukey tests (P<0.05). Cardiopulmonary stability was observed in both treatments during the surgery. The degree of analgesia and inflammation did not differ between groups. Rescue analgesia was administered to two dogs from each group. It was concluded that Arnica montana 12CH provides similar analgesic and anti-inflammatory effects when compared with ketoprofen, suggesting that this treatment is a safe and effective option to dogs undergoing ovariohysterectomy