To the practical design of the optical lever intracavity topology of gravitational-wave detectors

The QND intracavity topologies of gravitational-wave detectors proposed several years ago allow, in principle, to obtain sensitivity significantly better than the Standard Quantum Limit using relatively small anount of optical pumping power. In this article we consider an improved more ``practical'' version of the optical lever intracavity scheme. It differs from the original version by the symmetry which allows to suppress influence of the input light amplitude fluctuation. In addition, it provides the means to inject optical pumping inside the scheme without increase of optical losses. We consider also sensitivity limitations imposed by the local meter which is the key element of the intracavity topologies. Two variants of the local meter are analyzed, which are based on the spectral variation measurement and on the Discrete Sampling Variation Measurement, correspondingly. The former one, while can not be considered as a candidate for a practical implementation, allows, in principle, to obtain the best sensitivity and thus can be considered as an ideal ``asymptotic case'' for all other schemes. The DSVM-based local meter can be considered as a realistic scheme but its sensitivity, unfortunately, is by far not so good just due to a couple of peculiar numeric factors specific for this scheme. From our point of view search of new methods of mechanical QND measurements probably based on improved DSVM scheme or which combine the local meter with the pondermotive squeezing technique, is necessary.Comment: 27 pages, 6 figure

Dual-Resonator Speed Meter for a Free Test Mass

A description and analysis are given of a ``speed meter'' for monitoring a classical force that acts on a test mass. This speed meter is based on two microwave resonators (``dual resonators''), one of which couples evanescently to the position of the test mass. The sloshing of the resulting signal between the resonators, and a wise choice of where to place the resonators' output waveguide, produce a signal in the waveguide that (for sufficiently low frequencies) is proportional to the test-mass velocity (speed) rather than its position. This permits the speed meter to achieve force-measurement sensitivities better than the standard quantum limit (SQL), both when operating in a narrow-band mode and a wide-band mode. A scrutiny of experimental issues shows that it is feasible, with current technology, to construct a demonstration speed meter that beats the wide-band SQL by a factor 2. A concept is sketched for an adaptation of this speed meter to optical frequencies; this adaptation forms the basis for a possible LIGO-III interferometer that could beat the gravitational-wave standard quantum limit h_SQL, but perhaps only by a factor 1/xi = h_SQL/h ~ 3 (constrained by losses in the optics) and at the price of a very high circulating optical power --- larger by 1/xi^2 than that required to reach the SQL.Comment: RevTex: 13 pages with 4 embedded figures (two .eps format and two drawn in TeX); Submitted to Physical Review

Evaluation advanced lymph node dissection impact on long-term survival rate of gastric cancer patients. Journal of Education

Over a period of 2007-2011 188 stomach cancer (SC) patients have been included in the research in abdominal oncosurgical department of Odessa regional oncological dispensary. It was retrospective, one-center, nonrandomized research. Volume of lymph node dissections differed by quantity of lymph nodes to be removed. All patients were divided into three groups. Patients with D1 or D1+ lymph node dissections have been performed, totally 90 patients are included in group of historical control. The main group includes 33 patients to whom D3 lymph node dissections is executed and, finally, control group – 65 patients dissected up to the D2 volume. In all cases so-called lymph node dissections for principal reasons have been executed. The multifactorial analysis of patients survival is implemented depending on a type of a lymph node dissections, a stage of the cancer, number of involved lymph nodes, involvement of the tumoral microcirculatory net (ly is carried out, v) signs of a perinevral invasion (Nev), availability of residual tumoral tissue (R), degree of a differentiation (G). Regardless of a disease stage, SC at 60% of patients, represented with initially hematologicaly disseminated disease. 40% of SC`s had no signs of intratumoral microcirculatory net involvement even in case of more than 15 regional lymph nodes are involved. In the absence of a SC perinevral invasion appeared to be the most precise predictive marker. The conclusion is made some brand new additional53 prognostic factors could play a crucial role in more accurate patients selection for expanded lymph node dissections

Theory of superfast fronts of impact ionization in semiconductor structures

We present an analytical theory for impact ionization fronts in reversely biased p^{+}-n-n^{+} structures. The front propagates into a depleted n base with a velocity that exceeds the saturated drift velocity. The front passage generates a dense electron-hole plasma and in this way switches the structure from low to high conductivity. For a planar front we determine the concentration of the generated plasma, the maximum electric field, the front width and the voltage over the n base as functions of front velocity and doping of the n base. Theory takes into account that drift velocities and impact ionization coefficients differ between electrons and holes, and it makes quantitative predictions for any semiconductor material possible.Comment: 18 pagers, 10 figure

Ultra high-Q WGM microspheres from ZBLAN for the mid-IR band

The advantages of high-quality-factor whispering gallery mode microresonators can be applied to develop novel photonic devices for the mid-IR range. ZBLAN (glass based on heavy metal fluorides) is one of the most promising materials to be used for this purpose due to low optical losses in the mid-IR. We developed original fabrication method based on melting of commercially available ZBLAN-based optical fiber to produce high-Q ZBLAN microspheres with the diameters of 250 to 350 $\mu$m. We effectively excited whispering gallery modes in these microspheres and demonstrated high quality factor both at 1.55 $\mu$m and 2.64 $\mu$m. Intrinsic quality factor at telecom wavelength was shown $(5.4\pm0.4)\cdot10^8$ which is defined by the material losses in ZBLAN. In the mid-IR at 2.64 $\mu$m we demonstrated record quality factor in ZBLAN exceeding $10^8$ which is comparable to the highest values of the Q-factor among all materials in the mid-IR

Molecular genetic characteristics of gastric cancers from the surgeon’s point of view

Dubinina V. G., Mashukov A. A., Lukyanchuk O. V., Bilenko A. A., Zgura A. N., Raciborsky D. V., Lee S. N. Molecular genetic characteristics of gastric cancers from the surgeon’s point of view. Journal of Education, Health and Sport. 2016;6(11):592-621. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.200394 http://ojs.ukw.edu.pl/index.php/johs/article/view/4063 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016. MOLECULAR GENETIC CHARACTERISTICS OF GASTRIC CANCERS FROM THE SURGEON’S POINT OF VIEW V. G. Dubinina1, A. A. Mashukov2, O. V. Lukyanchuk2, A. A. Bilenko1, A. N. Zgura2, D. V. Raciborsky2, S. N. Lee2 1Odessa National Medical university 2Odessa Regional Oncology center Summary A study on the expression of oncoproteins in stomach` carcinomas, has been turned into a real research basically due to the abundance of results and their comprehensive interpretations. The study carried out on the abdominal onco-surgical department of Odessa Regional Oncology Center, included a study of 188 patients operated on for gastric cancer (GC) between 2007-2011. In all cases was performed the so-called lymphadenectomy for the principal reason of extensive preventive biopsy of visually unchanged lymph nodes. We spend a multivariate analysis of interactions between the expression of oncoproteins p53, VEGFR-3, erbB2, Ki67 and micro involvement of tumor vasculature (ly, v), the local growth (T), the presence of residual tumor tissue (the R), the degree of tumor differentiation (the G) the degree of regional lymph nodes involvement (N) and type of infiltration (Inf α, β, Inf Υ). Keywords: Stomach cancer, Immunohistochemistry and Oncoproteins

Analysis of survival after radical surgery for stomach cancer in odessa regional cancer center

The survival of patients with the locally advanced stage of stomach cancer (SC), who underwent various variants of preventive lymphatic nodes dissection, was considered. The survival of patients was compared with the stage and T, N indexes. Lymphadenectomy D2 were effective and increased cumulative survival in patient`s group T4aNoMo, stage IIB and T4aN1Mo, stage III A, and in groups of patients where D2 lymphadenectomy were ineffective - T4bNoMo, stage ІІІB, T4bN1Мo, stage ІІІB and T4aN2Мo, stage IIIB. D2 were more efficient operation in the case of tumor serosa invasion and invasion to the peritoneal cavity (SE) in the absence of multiple metastases to the regional lymph nodes (N1 according to the 7th revision of the classification - 1-2 metastatic lymph nodes), and when the tumor infiltrated the surrounding organs (SI) and the presence of multiple regional metastases, D2 lymphodissection did not gave positive results, comparising with D1

Comparison of survival rates made by the 6-th and 7-th editions of TNM classification in stomach cancer patients

The available classifications of malignant tumors reflect various aspects of their growth and some biological features. The most commonly used in Ukraine is the 6-th revision of TNM classification, which differs from the previous classifications of the section "Gastric cancer", mainly staging of category N, reflecting the presence of metastases in regional lymph nodes. Transition to the 7-th classification of TNM translates a part of patients from one stage to another, there is a so-called "stage migration" phenomenon. The famous mathematical phenomenon of Will Rogers describes this transition and theoretically substantiates its objectivity. The authors tracked the migration of patients and the change in the stage mainly from the point of view of the effect of this event on the survival of patients with stomach cancer

Optimizing the regimes of Advanced LIGO gravitational wave detector for multiple source types

We develop here algorithms which allow to find regimes of signal-recycled Fabry-Perot--Michelson interferometer (for example, Advanced LIGO), optimized concurrently for two (binary inspirals + bursts) and three (binary inspirals + bursts + millisecond pulsars) types of gravitational waves sources. We show that there exists a relatevely large area in the interferometer parameters space where the detector sensitivity to the first two kinds of sources differs only by a few percent from the maximal ones for each kind of source. In particular, there exists a specific regime where this difference is ~0.5 for both of them. Furthermore we show that even more multipurpose regimes are also possible, that provide significant sensitivity gain for millisecond pulsars with only minor sensitivity degradation for binary inspirals and bursts.Comment: 10 pages, 14 figures, 3 tables. Minor corrections in main text are done in version 2 and two plots and one table are added for the sake of clarity of the obtained result