2,137 research outputs found
Evidence for risk of bias in cluster randomised trials: review of recent trials published in three general medical journals
Objective To examine the prevalence of a risk of bias associated with the design and conduct of cluster randomised controlled trials among a sample of recently published studies. Design Retrospective review of cluster randomised trials published in the BMJ, Lancet, and New England Journal of Medicine from January 1997 to October 2002. Main outcome measures Prevalence of secure randomisation of clusters, identification of participants before randomisation (to avoid foreknowledge of allocation), differential recruitment between treatment arms, differential application of inclusion and exclusion criteria, and differential attrition. Results Of the 36 trials identified, 24 were published in the BMJ, I I in the Lancet, and a single trial in the New England journal of Medicine. At the cluster level, 15 (42%) trials provided evidence for secure allocation and 25 (69%) used stratified allocation. Few trials showed evidence of imbalance at the cluster level. However, some evidence of susceptibility to risk of bias at the individual level existed in 14 (39%) studies. Conclusions Some recently published cluster randomised trials may not have taken adequate precautions to guard against threats to the internal validity of their design
Improving Nutrition through Agriculture : Viewing agriculture-nutrition linkages along the smallholder value chain
This report is a synthesis of existing global knowledge on improving nutrition through agriculture using a smallholder value chain approach. The smallholder value chain model used by the desk review concentrates on both producers and consumers and is centred around three pathways: improved nutrition resulting from increased production for own consumption, improved nutrition through increased income from selling agricultural products, and improved nutrition through increased income resulting from farmersâ involvement in local or regional procurement programs. The report identifies key conditions for agricultural interventions to significantly contribute to nutrition as well as important knowledge gaps pertaining to agriculture-nutrition linkages
Transition frequency shifts with fine-structure constant variation for Yb II
In this paper we report calculations of the relativistic corrections to
transition frequencies (q factors) of Yb II for the transitions from the
odd-parity states to the metastable state 4f^{13}6s^2 ^2F_{7/2}^o. These
transitions are of particular interest experimentally since they possess some
of the largest q factors calculated to date and the state can be
prepared with high efficiency. This makes Yb II a very attractive candidate for
the laboratory search for variation of the fine-structure constant alpha.Comment: 5 page
A case study of argumentation at undergraduate level in history
This article examines two essays by undergraduate students in the first year of study in History at a university in the UK. It also draws on documentary evidence from the department in question and interviews with the students themselves to paint a picture of the way argumentation operates at this level. While no firm conclusions can be drawn, the evidence suggests a department with a high degree of awareness of the importance of argument and argumentation in studying History; and students who are aware and articulate about the problem facing them in constructing essays in the discipline. Suggestions are made about induction into the epistemological and argumentative demands of undergraduate study
Sources of bias in outcome assessment in randomised controlled trials: a case study
Randomised controlled trials (RCTs) can be at risk of bias. Using data from a RCT we considered the impact of post-randomisation bias. We compared the trial primary outcome, which was administered blindly, with the secondary outcome which was not administered blindly. 522 children from 44 schools were randomised to receive a one-to-one maths tuition programme that was assessed using two outcome measures. The primary outcome measure was assessed blindly whilst the secondary outcome was delivered by the classroom teacher and therefore this was un-blinded. The effect sizes for primary and secondary outcomes were substantially different (0.33 and 1.11 respectively). Test questions that were similar between the two tests this did not explain the difference. There was greater heterogeneity between schools for the primary outcome, compared with the secondary outcome. We conclude that, in this trial, the difference between the primary and secondary outcomes was likely to have been due to lack of blinding of testers
Human subjective response to steering wheel vibration caused by diesel engine idle
This study investigated the human subjective response to steering wheel vibration of the type caused by a four-cylinder diesel engine idle in passenger cars. Vibrotactile perception was assessed using sinusoidal amplitude-modulated vibratory stimuli of constant energy level (r.m.s. acceleration, 0.41 m/s(2)) having a carrier frequency of 26 Hz (i.e. engine firing frequency) and modulation frequency of 6.5 Hz (half-order engine harmonic). Evaluations of seven levels of modulation depth parameter m (0.0, 0.1, 0.2, 0.4, 0.6, 0.8, and 1.0) were performed in order to define the growth function of human perceived disturbance as a function of amplitude modulation depth. Two semantic descriptors were used (unpleasantness and roughness) and two test methods (the Thurstone paired-comparison method and the Borg CR-10 direct evaluation scale) for a total of four tests. Each test was performed using an independent group of 25 individuals. The results suggest that there is a critical value of modulation depth m = 0.2 below which human subjects do not perceive differences in amplitude modulation and above which the stimulus-response relationship increases monotonically with a power function. The Stevens power exponents suggest that the perceived unpleasantness is non-linearly dependent on modulation depth m with an exponent greater than 1 and that the perceived roughness is dependent with an exponent close to unity
Limit on the Temporal Variation of the Fine-Structure Constant Using Atomic Dysprosium
Over a period of eight months, we have monitored transition frequencies
between nearly degenerate, opposite-parity levels in two isotopes of atomic
dysprosium (Dy). These transition frequencies are highly sensitive to temporal
variation of the fine-structure constant () due to relativistic
corrections of large and opposite sign for the opposite-parity levels. In this
unique system, in contrast to atomic-clock comparisons, the difference of the
electronic energies of the opposite-parity levels can be monitored directly
utilizing a radio-frequency (rf) electric-dipole transition between them. Our
measurements show that the frequency variation of the 3.1-MHz transition in
Dy and the 235-MHz transition in Dy are 9.06.7 Hz/yr and
-0.66.5 Hz/yr, respectively. These results provide a value for the rate of
fractional variation of of yr (1
) without any assumptions on the constancy of other fundamental
constants, indicating absence of significant variation at the present level of
sensitivity.Comment: 4 pages, 2 figure
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