5,299 research outputs found
Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application
It has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell proliferation, cell migration and DNA repair. Epigenetic alterations comprise DNA methylation, histone modification, and microRNAs dysregulated expression and they play a significant role in the differentiation and proliferation properties of TC. In this review, our group assessed the published evidence on the tumorigenic role of epigenomics in Hurthle cell neoplasms (HCN), highlighting the yet limited, heteregeneous and non-validated data preventing its current use in clinical practice, despite the well developed assessment techniques available. The identified evidence gaps call for a joint endeavour by the medical community towards a deeper and more systematic study of HCN, aiming at defining epigenetic markers in early diagnose, allowing for accurate stratification of maligancy and disease risk and for effective systemic treatment.This work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 —Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). Additional funding by the European Regional Development Fund (ERDF) through the Operational Programme for Competitiveness and Internationalization—COMPETE2020, and Portuguese national funds via FCT, under project POCI-01-0145-FEDER-016390: CANCEL STEM and from the FCT under the project POCI-01-0145-FEDER-031438: The other faces of telomerase: Looking beyond tumor immortalization (PDTC/MED_ONC/ 31438/2017). Additional funding through the Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo – Bolsa Edward Limbert MERCK/SPEDM 2019. SC is supported by FCT in the framework of a PhD grant (SFRH/BD/ 147650/2019)
A model of active and significative learning in the resolution of problems
In this paper we present a description and analysis of an activity held in the
Mathematics courses in Engineering at the Universidade de Caxias do Sul. The
research was planned taking into account requirements for the training of engineers.
Analysis of activity indicates that major powers can be developed through active and
significative learning strategies. Students who agreed to participate in the activity
"Applications of Mathematics in Engineering" show, with their work, opportunities
to run, successfully, the path between the "do" and "understand." These skills are
related to the steps of the model of active and significative learning, proposed, and
are discussed in the analysis of the works presented.Peer Reviewe
An integrated project of entrepreneurship and innovation in engineering education
This paper presents a new line of project based learning in the School of Engineering of University of Minho:
the Innovation and Entrepreneurship Integrated Project (IEIP). Four groups, each one composed of
students from different engineering integrated master courses – Mechanical, Industrial Electronics and
Computers, Polymer, Industrial Management – compete against each other in developing or improving
commercial products manufactured by actual industries. There have been so far five editions of the IEIP,
with five different companies and five diverse products, however, all these products included components
that required knowledge from all the engineering courses involved. Only with the cooperation
between the students of the various courses that compose each multidisciplinary team, the success is
attainable. As each student has to deal with various engineering scopes, students’ technical skills are
greatly enlarged and they acquire a multidisciplinary knowledge that was not possible in another way.
Their soft skills like project management, teamwork, communication ability and personal development,
which are valuable requisites for their future employers, are also improved. The participating industries
also take advantage of the project: the groups competing against each other act as a multiskilled work
force, actually making proposals capable of improving their products, their efficiency, and reducing costs
Phase diagram of a 2D Ising model within a nonextensive approach
In this work we report Monte Carlo simulations of a 2D Ising model, in which
the statistics of the Metropolis algorithm is replaced by the nonextensive one.
We compute the magnetization and show that phase transitions are present for
. A phase diagram (critical temperature vs. the entropic
parameter ) is built and exhibits some interesting features, such as phases
which are governed by the value of the entropic index . It is shown that
such phases favors some energy levels of magnetization states. It is also
showed that the contribution of the Tsallis cutoff is essential to the
existence of phase transitions
Water reuse potential for irrigation in Brazilian hydrographic regions
The present paper carried out an evaluation of the reuse potential of the Wastewater Treatment
Plants (WWTPs) effluents for irrigation in the 12 Brazilian Hydrographic Regions (BHRs). For this
purpose, initially, the WWTPs were categorized and the effluent flow rate was estimated. Category 1
represents secondary effluent with an efficiency of organic matter removal greater than 80%;
Category 2 represents effluent that underwent some disinfection step; and effluents that perform
less than the other categories were called ?Uncategorized?. After that, the irrigation water demands
for each BHRs were compiled, and finally, the production of water for reutilization was compared
with the demand for irrigation. Thus, it was observed that all the sewage flow rates generated in
Brazil classified in Categories 1 and 2 represent 9% of the total irrigation water demand in the
country (1,078.71 m3/s) and it stands out that only 7% of the flows treated in Brazil undergo a tertiary
treatment step
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