460 research outputs found
Preventing failure of the anchoring system in underground coal mines
Cable bolts are commonly used as anchoring element in many underground mines. Reports on the premature failure of cable bolts in underground coal mines due to stress corrosion cracking (SCC) have been increasing in the past two decades. The previous studies found that the diffusion of atomic hydrogen into steel causes the SCC in cable bolts, which is known as hydrogen-induced stress corrosion cracking (HISCC). While the research on the mechanism of the HISCC in underground mines needs to be continued, it is essential to develop prevention measures to avoid such a failure. In this study, a variety of prevention measures that claim to prevent corrosion of steel were examined. Specifically, barrier coating, i.e., polymer, epoxy coating, as well as the sacrificial coating, i.e., hot-dip galvanising, methods were tested. Testing specimens were made by inserting loading pins between locked cable bolt king wires (coated) to simulate the in-situ stress condition. Cable bolt specimens were then fully immersed into a hydrogen sulphide solution to determine their resistance against HISCC. The test results showed that all the coatings had delayed the failure in varying degrees, but very few have significantly extended the time to fracturing. The polymer and epoxy coatings have become breached during the testing, and the failure occurred shortly after. The galvanised coating was dissolved in the testing solution and again allowed access of the solution to the steel surface, and subsequently resulted in failure. This indicates that these coatings can be potentially applied to prevent SCC failure; however, their impacts on the performance of bolts, such as their bonding with grout and bolt, still need to be considered
Digital and experimental rock analysis of proppant injection into naturally fractured coal
Proppant-laden fluid injection has been applied to many low permeability reservoirs, such as coal seams, to enhance permeability and thus production. While there are several laboratory-scale experimental studies on proppant placement in hydraulic fractures, the possible infiltration of proppant into natural fractures and its effect on overall permeability has received little attention. We study proppant injection into a naturally fractured coal sample by a combination of experimental and digital rock technologies. The sample was imaged using a helical X-ray computed tomography (micro-CT) scanner in as-received condition. Then, proppants of different size ranges were gradually injected into the sample, using a purpose-built X-ray transparent core flooding system, and the permeability was measured at different effective stresses. Subsequently, the propped sample was re-imaged and registered to the as-received image to map the internal changes. The experimental results indicated almost no permeability change of the sample after proppant injection. While proppant collection in the outlet proved passage of the proppant through the sample, observation of the sample indicated that some of the proppants were accumulated on the inlet face of the core and created a filter leading to no permeability increment. Micro-CT images confirmed that proppants were effectively placed in the sample and kept the fractures open. Numerical computation of permeability, using the digital coal sample in which accumulated proppants at the coal surface were excluded, indicated a significant increase in the sample permeability. Such an increase resulted from the opening of the fractures, particularly in the outlet region. This demonstrated the significance of proppant size selection for coal seam hydraulic fracturing. While proppants were successfully placed in the fractures, the experiment measured the permeability of the system, including proppants accumulated on the inlet, and could not effectively map the internal changes. This, therefore, needs to be considered when an experimental program for proppant injection is executed. To accurately monitor the internal changes, application of digital rock technology is recommended for such experiments
Stress corrosion cracking of cable bolts in tunnels: An in-situ testing approach
Premature failure of cable bolts in underground tunnels is a major concern for the mining and civil industries. The unexpected failure of cable bolts in tunnels can threaten the safety of excavation operations and cause subnational economic losses. In this study, an in-situ testing method was developed to identify the cause of failure in the environment where the cable bolts are installed. The testing was conducted in two underground mine tunnels in Australia. The coupon made from non-galvanised and galvanised cable bolt wires with multiple stressed sections were installed in the tunnel roof, allowing direct exposure of coupons to different rock strata environments. The coupons were retrieved from the tunnels after almost ten months and analysed for corrosion. Results from both tunnels showed the occurrence of stress corrosion cracking (SCC) in both non-galvanised and galvanised coupons. The cracking predominantly occurred in the sections exposed to claystone layers. The framework developed in this study can be applied to different regions of any underground spaces to assess the propensity of the environment to cause premature reinforcement failure
Microbiologically influenced corrosion of cable bolts in underground coal mines: The effect of Acidithiobacillus ferrooxidans
Reports on corrosion failure of cable bolts, used in mining and civil industries, have been increasing in the past two decades. The previous studies found that pitting corrosion on the surface of a cable bolt can initiate premature failure of the bolt. In this study, the role of Acidithiobacillus ferrooxidans (A. ferrooxidans) bacterium in the occurrence of pitting corrosion in cable bolts was studied. Stressed coupons, made from the wires of cable bolts, were immersed in testing bottles containing groundwater collected from an underground coal mine and a mixture of A. ferrooxidans and geomaterials. It was observed that A. ferrooxidans caused pitting corrosion on the surface of cable bolts in the near-neutral environment. The presence of geomaterials slightly affected the pH of the environment; however, it did not have any significant influence on the corrosion activity of A. ferrooxidans. This study suggests that the common bacterium A. ferrooxidans found in many underground environments can be a threat to cable bolts’ integrity by creating initiation points for other catastrophic failures such as stress corrosion cracking
Stress corrosion cracking of rockbolts: An in-situ testing approach
Premature failure of rockbolts due to stress corrosion cracking (SCC) is an unresolved global issue in underground structures, particularly underground mines. To date, SCC of rockbolts has been produced in laboratory-based studies under laboratory conditions, however no attempt to produce SCC in-situ in actual underground coal mine conditions has previously been made. In this study, an innovative testing methodology was used in which a rockbolt coupon was developed with multiple stressed sections. The test coupon could be placed in-situ within a borehole in an underground mine, exposing it to the borehole environment, the surrounding rock strata and the groundwater. In-situ coupons were made from both 1355 and HSAC840 grade rockbolt steels and installed within a typical rockbolted horizon where known SCC failure of rockbolts had occurred. SCC occurred in the 1355 grade in-situ coupons, but not in the HSAC840 grade ones despite service failures of HSAC840 rockbolts having occurred in the same underground mine. The difference in behaviour of the HSAC840 coupons and in-service rockbolts is most likely due to different stress regimes acting on the coupons and the rockbolts. Localised corrosion was observed on both steels although analysis of the groundwater indicated that it had low corrosivity. Microbiological analysis showed that a range of bacteria known to be involved in corrosion were present on the rockbolt coupons and in the underground environment. This suggested that the occurrence of localised corrosion and SCC in low corrosivity groundwater could be due to the presence of microbial organisms, in particular, sulphate reducing bacteria. The results of this study provide detailed insights into the SCC of rockbolts in the underground environment. The method developed here can be used to study other reinforcement elements and stressed settings for stress corrosion cracking
Microbiologically influenced stress corrosion cracking responsible for catastrophic failure of cable bolts
In the past two decades, reports of the premature failure of cable bolts used in the mining and civil industries have been increasing. Previous studies have established that failure occurs through hydrogen-induced stress corrosion cracking (HISCC), which is a type of environmentally assisted hydrogen cracking. However, to date, the cause of HISCC has been unclear. For the first time, we studied the role of microorganisms in the failure of cable bolts using components present in SCC-affected mines. Stressed coupons were prepared from the cable bolt wires and tested in groundwater with additions of sulphate-reducing bacteria, coal, clay, pyrite and lactate. It was found that hydrogen sulphide (H2S) produced by sulphate- and sulphur-reducing bacteria promoted hydrogen diffusion into the steel and, in the presence of stress, caused HISCC. This suggests that control of H2S production should be a priority for mining and civil industries to avoid premature failure of anchoring systems
Eltrombopag for the treatment of immune thrombocytopenia: The aegean region of Turkey experience
Objective: Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease of the platelet count to less than 100x109/L. Although it is included in a benign disease group, bleeding complications may be mortal. With a better understanding of the pathophysiology of the disease, thrombopoietin receptor agonists, which came into use in recent years, seem to be an effective option in the treatment of resistant cases. This study aimed to retrospectively assess the efficacy, long-term safety, and tolerability of eltrombopag in Turkish patients with chronic ITP in the Aegean region of Turkey. Materials and Methods: Retrospective data of 40 patients with refractory ITP who were treated with eltrombopag in the Aegean region were examined and evaluated. Results: The total rate of response was 87%, and the median duration of response defined as the number of the platelets being over 50x109/L was 19.5 (interquartile range: 5-60) days. In one patient, venous sinus thrombosis was observed with no other additional risk factors due to or related to thrombosis. Another patient with complete response and irregular follow-up for 12 months was lost due to sudden death as the result of probable acute myocardial infarction. Conclusion: Although the responses to eltrombopag were satisfactory, patients need to be monitored closely for overshooting platelet counts as well as thromboembolic events. © 2015 Turkish Society of Hematology. All rights reserved
Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virus
Considerable interest has been focused on inducing RNA interference (RNAi) in neurons to study gene function and identify new targets for disease intervention. Although small interfering RNAs (siRNAs) have been used to silence genes in neurons, in vivo delivery of RNAi remains a major challenge limiting its applications. We have developed a highly efficient method for in vivo gene silencing in dorsal root ganglia (DRG) using replication-defective herpes simplex viral (HSV-1) vectors. HSV-mediated delivery of short-hairpin RNA (shRNA) targeting reporter genes resulted in highly effective and specific silencing in neuronal and non-neuronal cells in culture and in the DRG of mice in vivo including in a transgenic mouse model. We further establish proof of concept by demonstrating in vivo silencing of the endogenous trpv1 gene. These data are the first to show silencing in DRG neurons in vivo by vector-mediated delivery of shRNA. Our results support the utility of HSV vectors for gene silencing in peripheral neurons and the potential application of this technology to the study of nociceptive processes and in pain gene target validation studies
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