Formation of Socio-cultural Competence in Foreign Language Teaching

AbstractThe purpose of this paper is to describe the process of the formation of socio-cultural competence in foreign language teaching, and the possibility of using the discipline “Foreign Language” in achieving this goal. The importance of students’ socio-cultural competence formation is caused by modern Russian society inconsistencies: on the one hand globalisation processes are going on, and on the other inter-ethnic relations are getting worse, and conflicts are getting more violent. The characteristics of the components of socio-cultural competence are outlined in the paper and the stages of this competence formation (motivational, informative, activity) in teaching a foreign language in high school with the use of effective methods and technologies are described

Прогнозирование динамических характеристик термопар с тонкопроволочными чувствительными элементами

Thermocouples dynamic characteristicsʼ prediction is one of the relevant directions in the field of dynamic measurements of non-stationary temperatures of liquid and gaseous media. Thermocouples dynamic characteristicsʼ prediction makes it possible to provide effective continuous correction in automatic control systems for non-stationary temperatures. The purpose of this paper was to develop a theoretically justified relation linking the current or expected time constant of fine-wire thermocouples with the known time constant established at known parameters of liquid and gaseous media.A formula linking the time constant of fine-wire thermocouples with the conditions of heat exchange with the measured medium and the thermophysical characteristics of the thermocouple sensing elements has been deducted. An approximate formula is also given for calculating the internal resistance of wire sensing elements of thermocouples, which must be considered when calculating the time constant of a thermocouple. In consideration of the obtained formulas, a multi-parameter relation linking the current or expected time constant of fine-wire thermocouples with the known time constant set at the known parameters of the measured media has been formed.It is suggested to simplify the formed multi-parameter relation and make it dependent, for example, on the “expected velocity of the measured medium × expected density of the measured medium” complex (Vm2 ρm2 ). Simplified relations in the form of hyperbolic functions with constant parameters and argument in the form of Vm2 ρm2 complex were obtained for airflowat different temperatures, pressures, and velocities.On the example of airflow, it is shown that the complex multi-parametric relation linking the expectedand known time constants of thermocouples can be simplified to a hyperbolic dependence, where the argument can be the Vm2 ρm2 complex. Moreover, the degree of approximation of hyperbolic dependencies to the exact values of the multi-parametric relation can reach the R-square = 0.9592 criterion.A multi-parametric relation has been proposed. That relates the known time constant of a thermocouple to the expected or current time constant of the same thermocouple at other parameters of the measured medium from the point of view of the heat exchange and thermal conduction theory. The proposed relation can be used in automatic control systems of non-stationary temperature of various liquid or gaseous media to provide continuous correction of thermocouples dynamic characteristics. Depending on the number of measured medium parameters, the suggested multi-parameter relation can be replaced by simplified relations with other complexes containing, for example, density, velocity, flow rate and pressure of the measured medium.Прогнозирование динамических характеристик термопар является одним из актуальных направлений в области динамических измерений нестационарных температур жидких и газообразных сред. Прогнозирование динамических характеристик термопар позволяет обеспечить эффективную непрерывную коррекцию в системах автоматического управления нестационарной температурой. Целью данной работы являлась разработка теоретически обоснованного соотношения, связывающего текущую или ожидаемую постоянную времени тонкопроволочных термопар, с известной постоянной времени, установленной при известных параметрах жидких и газообразных сред.Выведено выражение, связывающее постоянную времени тонкопроволочных термопар с условиями теплообмена с измеряемой средой и теплофизическими характеристиками чувствительных элементов термопар. Получена также приближённая формула для расчёта внутреннего сопротивления проволочных чувствительных элементов термопар, которое необходимо учитывать при вычислении постоянной времени термопары. С учётом полученных выражений сформировано многопараметрическое соотношение, связывающее текущую или ожидаемую постоянную времени тонкопроволочных термопар, с известной постоянной времени, установленной при известных параметрах измеряемых сред.Сформированное многопараметрическое соотношение предложено упростить и сделать зависимым, например, от комплекса «ожидаемая скорость измеряемой среды × ожидаемая плотность измеряемой среды» (Vm2 ρm2 ). Для воздушного потока при различных температурах, давлении и скорости получены упрощённые соотношения в виде гиперболических функций с постоянными параметрами и аргументом в форме комплекса Vm2 ρm2.На примере воздушного потока показано, что сложное многопараметрическое соотношение,связывающее ожидаемую и известную постоянные времени термопар, можно упростить до гиперболической зависимости, где аргументом может выступить комплекс Vm2 ρm2. Причём степень приближения гиперболических зависимостей к точным значениям многопараметрического соотношения может достигать по критерию R-square = 0.9592.Предложено точное с точки зрения теории теплообмена и теплопроводности многопараметрическое соотношение, связывающее известную постоянную времени термопары с ожидаемой или текущей постоянной времени этой же термопары при иных параметрах измеряемой среды. Предложенное соотношение может быть использовано в системах автоматического управления нестационарной температурой различных жидких или газообразных сред для обеспечения непрерывной коррекции динамических характеристик термопар. В зависимости от числа измеряемых параметров среды предложенное многопараметрическое соотношение может быть заменено упрощёнными измеряемой соотношениями с другими комплексами, содержащими, например, плотность, скорость, расход и давление среды

Integration of the seismic and geochemistry data to evaluate hydrocarbon potential of the carbonate reservoirs in Tatarstan, Russia

© SGEM2018. The article describes the results of the integration of the geochemical and seismic data on one of the oilfields of Tatarstan Republic in Russian Federation. The complex geological structure of the oil bearing formations of Carboniferous age results in misinterpretation of the geophysical data and drilling of the dry wells. Some potential structural oil traps find from the seismic data interpretation are water bearing. To avoid nonproductive drilling authors studied seismic faults and their connection with the geochemical anomalies. On the first step the faults in the potential oil-bearing formation of the Tournaisian age were traced in the 2D seismic lines. Then the geochemical parameter (propane concentration in the soils) was studied in 90 observation points. The gas anomaly represented by propane is indicative, because the biochemical genesis of methane homologues is practically excluded, and their content in coal is insignificant. That means that the increased content of propane is connected with the presence of hydrocarbons. It appears that in the presents of oil in the formation geochemical anomaly and the fault in the Tournaisian formation are coincide. That can be used as additional source of information to avoid nonproductive drilling

Mutational landscape of head and neck squamous cell carcinomas in a South Asian population

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is anmong the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigation of the disease at the genomic level. Whole exome sequencing of HNSCC samples and matched normal genomic DNA (n=7) was performed. Significant somatic single nucleotide variants (SNVs) were identified and pathway analysis performed to determine frequently affected signaling pathways. We identified significant, novel recurrent mutations in ASNS (asparagine synthetase) that may affect substrate binding, and variants in driver genes including TP53, PIK3CA, FGFR2, ARID2, MLL3, MYC and ALK. Using the IntOGen platform, we identified MAP kinase, cell cycle, actin cytoskeleton regulation, PI3K-Akt signaling and other pathways in cancer as affected in the samples. This data is the first of its kind from the Pakistani population. The results of this study can guide a better mechanistic understanding of HNSCC in the population, ultimately contributing new, rational therapeutic targets for the treatment of the disease

Dietary studies in birds: testing a non-invasive method using digital photography in seabirds

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Dietary studies give vital insights into foraging behaviour, with implications for understanding changing environmental conditions and the anthropogenic impacts on natural resources. Traditional diet sampling methods may be invasive or subject to biases, so developing non-invasive and unbiased methods applicable to a diversity of species is essential. We used digital photography to investigate the diet fed to chicks of a prey-carrying seabird and compared our approach (photo-sampling) to a traditional method (regurgitations) for the greater crested tern Thalasseus bergii. Over three breeding seasons, we identified >24 000 prey items of at least 48 different species, more than doubling the known diversity of prey taken by this population of terns. We present a method to estimate the length of the main prey species (anchovy Engraulis encrasicolus) from photographs, with an accuracy <1 mm and precision ~ 0·5 mm. Compared to regurgitations at two colonies, photo-sampling produced similar estimates of prey composition and size, at a faster species accumulation rate. The prey compositions collected by two researchers photo-sampling concurrently were also similar. Photo-sampling offers a non-invasive tool to accurately and efficiently investigate the diet composition and prey size of prey-carrying birds. It reduces biases associated with observer-based studies and is simple to use. This methodology provides a novel tool to aid conservation and management decision-making in the light of the growing need to assess environmental and anthropogenic change in natural ecosystems.Department of Science and Technology, South Afric

Everolimus in patients with metastatic renal cell carcinoma previously treated with bevacizumab: a prospective multicenter study CRAD001LRU02T⃰

Everolimus is an orally administered inhibitor of the mammalian target of rapamycin (mTOR) recommended for patients with metastatic renal cell carcinoma (mRCC) who progressed on previous vascular endothelial growth factor (VEGF) receptor-tyrosine kinase inhibitor therapy. Efficacy of everolimus in patients who progressed on anti-VEGF monoclonal antibody bevacizumab is unknown. We did a multicenter prospective trial of everolimus in patients with mRCC whose disease had progressed on bevacizumab ± interferon alpha (IFN). Patients with clear-cell mRCC which had progressed on bevacizumab ± IFN received everolimus 10 mg once daily. The primary end point was the proportion of patients remaining progression-free for 56 days, and a two-stage Simon design was used, with 80 % power and an alpha risk of 5 %. This study is registered with ClinicalTrials.gov, number NCT02056587. From December 2011 to October 2013, a total of 37 patients (28 M, 9 F) were enrolled. Median age was 60.5 years (range 41-66), 11 % had Eastern Cooperative Oncology Group Performance Status (ECOG PS) &gt; 2, and Memorial Sloan-Kettering Cancer Center (MSKCC) favorable/intermediate risk was 38/62 %. Five (14 %) patients had a confirmed partial response and 26 (70 %) patients had a stable disease. Median progression-free survival was 11.5 months (95 % CI, 8.8–14.2). Median overall survival was not reached. No grade 3 or 4 treatment-related toxicities were observed. The most common grade 2 adverse events were fatigue (19 %) and pneumonitis (8 %). Everolimus demonstrated a favorable toxicity profile and promising anti-tumor activity as a second-line therapy in metastatic renal cell carcinoma (RCC) patients previously treated with bevacizumab ± IFN

Effects of gama irradiation on nucellar callus production of lhe 'Valência' sweet orange (Citrus sinsensis) Osb. in vitro.

Os métodos convencionais pouco têm contribuído para o melhoramento das espécies cítricas. A utilização das técnicas de cultura in vitro associadas à indução de mutações deverão trazer inestimável contribuição. Nucelos extraídos de frutos em desenvolvimento, doze semanas após a polinização, foram cultivados in vitro em meio "MS" adicionado (em mg/ 1) de: tiamina HCQ - 0,2; piridoxina HCQ - 1,0; ácido nicotínico - 1,0; mesoinositol - 100; extrato de malte - 500; sacarose - 50.000; ágar - 8.000, com pH ajustado para 5,7. Procedeu-se à irradiação, apenas do meio ou do nucelo, ou de ambos, nas doses de 0,0, 0,5, 1,0, 2,0, 4,0, 8.0 e 12,0 kR. A irradiação apenas do nucelo mostrou um efeito similar ao obtido pela irradiação tanto do nucelo como do meio. Doses baixas de radiação (até 2 kR) reduzem o número de embrióides diferenciados. A irradiação do meio de cultura aumenta a proliferação de calos, principalmente em doses mais elevadas.The conventional methods of plant breeding have not given a significative contribution for the citrus breeding. A precious iniprovement by the techniques of tissues culture in vitro, associated with induced mutations, is expected. Nucelli extracted from developping fruits with twelve weeks after pollination were cultured in vitro, on medium supplemented (in mg/ 1) by: thiamine HCQ 0.2; piridoxine HCL 1.0;  icotinic acid 1.0; mesoinositol 100; malt extract; sucrose 50.000; and agar 8.000 with pi-! = 5.7. The irradiation at 0.0; 0.5; 1.0; 2.0; 4.0; 8.0 and 12.0 kR doses was applied on, only medium, only nucellus, and medium and nucellus together. Irradiation of only nucellus and both nucellus and medium, at the same time, showed similar effects. Low doses of irradiation (until 2 kR) decrease the number of differential embryoids. The irradiation of culture medium, mainly at high doses, increases callus proliferatio

Clinical case of crohn's disease in pediatric practice

The purpose of the study is to study the clinical features and course of Crohn's disease in a child with a manifestation during puberty.Цель исследования – изучить особенности клиники и течения болезни Крона у ребенка с манифестом в период полового созревания