Experimental demonstration of fractional orbital angular momentum entanglement of two photons

The singular nature of a non-integer spiral phase plate allows easy manipulation of spatial degrees of freedom of photon states. Using two such devices, we have observed very high dimensional (D > 3700) spatial entanglement of twin photons generated by spontaneous parametric down-conversion.Comment: submitted to Phys. Rev. Let

CNOT and Bell-state analysis in the weak-coupling cavity QED regime

We propose an interface between the spin of a photon and the spin of an electron confined in a quantum dot embedded in a microcavity operating in the weak coupling regime. This interface, based on spin selective photon reflection from the cavity, can be used to construct a CNOT gate, a multi-photon entangler and a photonic Bell-state analyzer. Finally, we analyze experimental feasibility, concluding that the schemes can be implemented with current technology.Comment: 4 pages, 2 figure

Detection of sub-shot-noise spatial correlation in high-gain parametric down-conversion

Using a 1GW-1ps pump laser pulse in high gain parametric down-conversion allows us to detect sub-shot-noise spatial quantum correlation with up to one hundred photoelectrons per mode, by means of a high efficiency CCD. The statistics is performed in single-shot over independent spatial replica of the system. The paper highlights the evidence of quantum correlation between symmetrical signal and idler spatial areas in the far field, in the high gain regime. In accordance with the predictions of numerical calculations the observed transition from the quantum to the classical regime is interpreted as a consequence of the narrowing of the down-converted beams in the very high gain regime.Comment: 4,2 pages, 4 figure

Shannon dimensionality of quantum channels and its application to photon entanglement

We introduce the concept of Shannon dimensionality D as a new way to quantify bipartite entanglement as measured in an experiment. This is applied to orbital-angular-momentum entanglement of two photons, using two state analyzers composed of a rotatable angular-sector phase plate that is lens-coupled to a single-mode fiber. We can deduce the value of D directly from the observed two-photon coincidence fringe. In our experiment, D varies between 2 and 6, depending on the experimental conditions. We predict how the Shannon dimensionality evolves when the number of angular sectors imprinted in the phase plate is increased and anticipate that D = 50 is experimentally within reach.Comment: 4 pages, 3 figures, accepted for Physical Review Letter

The impact of patient-reported frailty on cardiovascular outcomes in elderly patients after non-ST-acute coronary syndrome

Background: As life expectancy increases, the population of older individuals with coronary artery disease and frailty is growing. We aimed to assess the impact of patient-reported frailty on the treatment and prognosis of elderly early survivors of non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: Frailty data were obtained from two prospective trials, POPular Age and the POPular Age Registry, which both assessed elderly NSTE-ACS patients. Frailty was assessed one month after admission with the Groningen Frailty Indicator (GFI) and was defined as a GFI-score of 4 or higher. In these early survivors of NSTE-ACS, we assessed differences in treatment and 1-year outcomes between frail and non-frail patients, considering major adverse cardiovascular events (MACE, including cardiovascular mortality, myocardial infarction, and stroke) and major bleeding. Results: The total study population consisted of 2192 NSTE-ACS patients, aged ≥70 years. The GFI-score was available in 1320 patients (79 ± 5 years, 37% women), of whom 712 (54%) were considered frail. Frail patients were at higher risk for MACE than non-frail patients (9.7% vs. 5.1%, adjusted hazard ratio [HR] 1.57, 95% confidence interval [CI] 1.01–2.43, p = 0.04), but not for major bleeding (3.7% vs. 2.8%, adjusted HR 1.23, 95% CI 0.65–2.32, p = 0.53). Cubic spline analysis showed a gradual increase of the risk for clinical outcomes with higher GFI-scores. Conclusions: In elderly NSTE-ACS patients who survived 1-month follow-up, patient-reported frailty was independently associated with a higher risk for 1-year MACE, but not with major bleeding. These findings emphasize the importance of frailty screening for risk stratification in elderly NSTE-ACS patients.</p

Pharmaco-invasive therapy: Early implementation of statins and proprotein convertase subtilisin/kexin type 9 inhibitors after acute coronary syndrome

Elevated LDL-cholesterol (LDL-C) plays a major role in atheroma formation and inflammation. Medical therapy to lower elevated LDL-C is the cornerstone for reducing the progression of atherosclerotic cardiovascular disease. Statin therapy, and more recently, other drugs such as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, have proven efficacy in long-term lowering of LDL-C and therefore diminish cardiovascular risk. During an acute coronary syndrome (ACS), a systemic inflammatory response can destabilize other non-culprit atherosclerotic plaques. Patients with these vulnerable plaques are at high risk of experiencing recurrent cardiovascular events in the first few years post-ACS. Initiating intensive LDL-C lowering therapy in these patients with statins or PCSK9 inhibitors can be beneficial via several pathways. High-intensity statin therapy can reduce inflammation by directly lowering LDL-C, but also through its pleiotropic effects. PCSK9 inhibitors can directly lower LDL-C to recommended guideline thresholds, and could have additional effects on inflammation and plaque stability. We discuss the potential role of early implementation of statins combined with PCSK9 inhibitors to influence these cascades and to mediate the associated cardiovascular risk, over and above the well-known long-term beneficial effects of chronic LDL-C lowering

Evaluation of pulmonary arterial hypertension: invasive or noninvasive?

Vascular Biology and Interventio