Prospect Hill: Skeletal Remains from a 19th-Century Methodist Cemetery, Newmarket, Ontario

During 1989-90, in response to disruption caused by a building site excavation in Newmarket, Ontario, archaeological and biological information was salvaged from a former church cemetery dating from 1824 or 1827 to 1879. The skeletal remains of 77 indivaduals indicate a population with high infant mortality and little access to medical or dental care. Nevertheless, the autopsy of a young pregnant woman and one gold dental filling indicate there was an incipient interest in biomedical that mechanisms be available to allow the salvage of as much historical and biological information as possible

Fatigue and Recovery Profiles of Unilateral Resistance Exercise in a Resistance Trained Population

Recent data shows that fatiguing unilateral isometric contractions affect the performance of the non-exercising, contralateral muscles (i.e., cross-over effect). However, there is limited data on the time-course of the contralateral response, whether the effects occur during resistance exercise, and the influence of resistance training experience. PURPOSE: To examine force and electromyographic (EMG) activity during and after a fatiguing unilateral resistance exercise protocol for the ipsilateral and contralateral elbow flexors in a resistance trained population. METHODS: Eight participants (7 right hand dominant; mean age=22yrs; 7 males; resistance trained with ≥ 2days/week upper body) visited the laboratory on two days separated by ≥ 48 hrs. On the first visit, maximal dynamic strength was determined for the ipsilateral arm and control procedures for maximal isometric strength of the contralateral arm was performed. On the second visit, participants completed 4 sets of unilateral dynamic bicep curls to failure with 50% 1RM with 2 min rest intervals between sets. Maximal voluntary contractions (MVC) and EMG activity of the elbow flexors were recorded immediately before exercise and after each set for both arms, except for set 1 and 3 where only the ipsilateral arm performed MVC’s. The responses during acute recovery were recorded at 2.5 min, 5 mins, and 10 mins post exercise. Separate repeated measures ANOVA tests were performed on the MVC and EMG responses for each arm. Alpha was set at 0.05. RESULTS: The results of the analysis show that for the ipsilateral arm, baseline MVC values declined to set 1 (p\u3c0.01; ~26%), with no significant differences in force loss thereafter for set 2 (~29%), set 3 (~28%), set 4 (~30%), recovery 1 (~28%), recovery 2 (~27%), or recovery 3 (~24%). There was no significant change in maximal EMG activity for the ipsilateral biceps brachii (p=0.189; ηp2 =0.177). For the contralateral biceps brachii, there was no significant difference across time in maximal EMG activity between the fatigue visit versus the control visit (p=0.732; ηp2=0.018). However, collapsed across visit, there was a significant decrease in maximal EMG amplitude (p\u3c0.01; ηp2=0.614) that appears to be explained by the fatigue visit (p=0.319; d=0.379). For the contralateral arm, there was no significant change in MVC across time for either visit (p=0.166; ηp2=0.211). CONCLUSION: These results show that following acute resistance exercise performed to failure, there is no change in maximal force of the contralateral elbow flexors. This finding brings into question whether the cross-over effect of fatigue occurs during resistance exercise or in resistance trained populations. The fatigability profile of the ipsilateral arm demonstrates there was no compounding effect on force loss with additional sets to failure. The lack of force recovery following acute resistance exercise emphasizes the importance of task dependency. The applications of these data suggests that relative fatigability may not be a useful metric to monitor training session outcomes

TREATMENT OF EXPERIMENTAL PERIODONTITIS BY TERPENE-CONTAINING MEDICATION

Therapeutic effect of terpenoidisobornylacetate-containing preparation Antiran on the inflammatory process in paradontium in 56 white outbread rats was researched. Animals of control group wasn't provide the treatment, animals of treatment group had antibiotic dialysis from 1st till 3rd day, ultrasound curettage with Antiran solution on the 4th day, Antiran dialysis in the paradontium tissues for 20 minutes OD from 5th to 14th day. Inflammatory process was studied using morphological methods. It was showed that Aniran arrests an inflammation, prevents secondary alteration of tissues, promotes reparative processes and recovery of damaged tissues

Pre-Sleep Low Glycemic Modified Starch Does Not Improve Next Morning Running Performance in Endurance Athletes

Click the PDF icon to download the abstrac

The research of antibacterial properties of decamethoxin, decasan, horosten

The study of Staphylococcus resistance to the antibacterial drugs Decamethoxin, Decasan, Horosten remains an important medical problem. The aim of this study was to investigate the antistaphylococcal properties of Decamethoxin, Decasan, Horosten. It has been proven that qaterinary ammonium antiseptic drugs (Decamethoxin, Decasan, Horosten) have high antistaphylococcal properties. The bactericidal activity of Decamethoxin has been shown to be stable under adverse pH conditions of different microbial loading. Different concentrations of Decamethoxine have been shown to cause the formation of resistant variants of Staphylococcus, which lose the ability to form pigments and enzymes

Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine

Based on the pivotal trial showing no clinicallyrelevant differences between pegylated interferon α-2b (Peg-α-2b) and α-2a (Peg-α-2a) combined with ribavirin for treatment of chronic hepatitis C virus (HCV) genotype 1 infection in Ukraine, a cost-minimization analysis was performed using a 1 year time horizon and both a health care and patients' perspective. A decision tree reflects treatment pathways. Drug costs were based on drug labeling and adjusted to the average body mass in Ukraine. Subgroup analysis was applied to deal with heterogeneity of patient's weight causing dose changes. A break-even price of Peg-α-2a and Peg-α-2b (based on the average dose) was calculated. Univariate sensitivity analyses and probabilistic sensitivity analysis were carried out to reflect decision uncertainty. For an average body weight, total medical costs per patient differ from US$9220 for Peg-α-2b to US$9513 for Peg-α-2a from a health care perspective, and from US$15,212 to US$15,696 from a patients' perspective. Sensitivity analyses show these results are robust. With average body weight, the break-even price of Peg-α-2b may be 7.3% higher than Peg-α-2a to have similar total costs

Прогнозування міцності та розподілу бокового тиску при виробництві пресованих бетонних дорожніх каменів

У монографії висвітлено питання прогнозування міцності та розподілу бокового тиску при виробництві пресованих бетонних виробів з викорис-танням теорії нечіткої логіки та регресійного аналізу. Викладено результа-ти теоретичних та експериментальних досліджень величини прогнозованої міцності бетонних виробів. На базі апарату нечіткої логіки розроблено програмний модуль, який можна адаптувати до цільової функції шляхом навчання моделі. Матеріал монографії може бути корисним для студентів інженерно-будівельних спеціальностей, аспірантів, інженерних робітників.The monograph covers the issues of the strength prediction and lateral pressure’s distribution in the manufacture of pressed concrete products by using the theory of fuzzy logic and regression analysis. The results of theoretical and experimental research of predicted strength of concrete products value are shown. The software module is developed on the basis of fuzzy logic that can be adapted to the objective function by model learning. Material of the monograph can be useful to students of engineering and construction specialties, graduate students, engineering workers

D-dimer as a potential predictor of thromboembolic and cardiovascular complications in patients with chronic kidney disease

The aim of the study was to evaluate the relationship between D-dimer levels and different biomarkers­ of renal diseases to identify the relationship between hypercoagulation and chronic kidney disease (CKD). To achieve this aim, we conducted a one-step prospective observational study involving 140 patients with CKD who were hospitali­zed in Ivano-Frankivsk Regional Clinical Hospital in Ukraine during 2018-2019. Of these patients, 100 patients (71.4%; 95% CI 53.4-76.7) had glomerulonephritis (GN) and 40 patients (28,6%; 95% CI 21.3-36.8) had diabetic nephropathy (DN). All patients underwent standard examination, which included general clinical, biochemical and instrumental research methods. D-dimer was quantitatively determined in blood serum by enzyme-linked immunosorbent assay (ELISA). The 140 patients were divided into two groups according to the level of D-dimers: normal level (<0.5 mg/l) and elevated level (≥0.5 mg/l). Elevated D-dimer levels were associated with an increased age of patients, decreased glomerular filtration rate, decreased blood albumin level, increased daily protein excretion and a tendency to develop thromboembolic complications during 1 year of monitoring. D-dimer is a biological marker that can detect hypercoagulation at an early preclinical stage in patients with CKD and identify patients with an increased cardiovascular risk, thereby promoting the earliest use of antiplatelet agents and anticoagulants and, consequently, it can reduce mortality­