Formulation and Development of Orodispersible Tablet of Baclofen by Effervescent Method

The aim of the present study was to develop orodispersible tablets of Baclofen for improving patient compliance, by overcoming the difficulties in swallowing, with the prime objective of arriving at cost effective product by effervescent method. In the effervescent method, mixture of sodium bicarbonate and tartaric acid (each of 12% w/w concentration) were used along with super disintegrants, i.e., treated agar, sodium starch glycolate (SSG), Cross Carmellose Sodium (CCS) and Microcrystalline Cellulose (MCC). The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, in vitro dispersion time. The hardness and friability test reports revealed that the tablets had a good mechanical strength and resistance. The formulation containing high concentration of MCC, SSC and CCS and mixture of effervescent emerged as the best formulation based on in vitro drug release characteristics. The results of this work suggest that orodispersible tablets of Baclofen with rapid disintegration time, fast drug release and good hardness can be efficiently and successfully formulated by effervescent method

RECENT PROGRESS OF DENDRIMERS IN DRUG DELIVERY FOR CANCER THERAPY

With the recent advances of nanotechnology, dendrimers are emerging as a highly attractive class of drug delivery vectors for cancer therapy. Dendrimers are multifunctional smart Nanocarriers to deliver one or more therapeutic agent safely and selectively to cancer cells. The high level of control over the synthesis of dendritic architecture makes dendrimers a nearly perfect (spherical) nanocarrier for site-specific drug delivery. The presence of functional groups in the dendrimers exterior also permits the addition of other moieties that can actively target certain diseases which are now widely used as tumor targeting strategies. Drug encapsulation, solubilization and passive targeting also equally contribute to the therapeutic use of dendrimers. Dendrimers are ideal carrier vehicles on cytotoxicity, blood plasma retention time, biodistribution and tumor uptake. In this review we highlight the advantages of dendrimers over conventional chemotherapy, toxicity and its management, following anti-cancer drugs delivered by using dendrimers and recent advances in drug delivery by various types of dendrimers as well as its diagnostic applications

Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry

The present research work discusses the development and validation of a UV spectrophotometric method for Exemestane. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Exemestane in Tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 246 nm. The percentage recovery of Exemestane was in the 98.7±0.4. Beers law was obeyed in the concentration range of 2-14 µg/mL. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.05954x+0.0000 with r2 of 0.9938 was obtained. Validation was performed according to ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method may be suitable for the analysis of Exemestane in tablet formulation for quality control purposes

Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol

The potential of proniosomes as a transdermal drug delivery system for Atenolol was investigated by encapsulating the drug in various formulations of proniosomal gel composed of various ratios of sorbitan fatty acid esters, cholesterol, lecithin prepared by Coacervation-phase separation method. The objectives of the present study were to define effects on the antihypertension activity and pharmacokinetics of a novel transdermal Proniosomal gel incorporating Atenolol. The formulated systems were characterized in vitro for size, drug entrapment, In vitro and in vivo drug permeation profiles and vesicular stability at different storage conditions. The optimized Atenolol proniosomes (AT8) showed nanometric vesicle size, high entrapment efficiency and marked enhancement in transdermal permeation. The prepared Proniosomal gel showed the relative bioavailability of 365.38 fold increased for AT8 than oral. The maximal concentrations (Cmax), of drug were significantly reduced while the areas under the plasma concentration–time curve (AUC), and mean residence times (MRT), t1/2 were evidently increased and extended, respectively. The results suggest that proniosomes can act as promising carrier which offers an alternative approach for transdermal delivery of Atenolol. Keywords: Proniosomes, Atenolol, Niosomes, Pharmacokinetic study, Transdermal deliver

Formulation And Evaluation Of Losartan Hydrogel Beads

Losartan is a potent calcium channel blocker used in the treatment of hypertension. Losartan has shorter half life of 2 hours.The objective of study is to formulate and evaluate the alginate hydrogel beads of Losartan as a model drug by ionicgeleation method using cacl2 as cross linking agent. the hydrogel beads were formulated using sodium alginate, HPMC andCarbopol as polymers. The drug is deliver at controlled/sustained manner into GIT consequently to the systemic circulation.the prepared hydrogels were evaluated for particle size, flow properties, entrapment efficiency, swelling index, %yield andin-vitro drug release studies.From the five different formulations, we found that F5 has shown best performance and % drugrelease and when we compare to other formulations