Formulation And Evaluation Of Losartan Hydrogel Beads

Abstract

Losartan is a potent calcium channel blocker used in the treatment of hypertension. Losartan has shorter half life of 2 hours.The objective of study is to formulate and evaluate the alginate hydrogel beads of Losartan as a model drug by ionicgeleation method using cacl2 as cross linking agent. the hydrogel beads were formulated using sodium alginate, HPMC andCarbopol as polymers. The drug is deliver at controlled/sustained manner into GIT consequently to the systemic circulation.the prepared hydrogels were evaluated for particle size, flow properties, entrapment efficiency, swelling index, %yield andin-vitro drug release studies.From the five different formulations, we found that F5 has shown best performance and % drugrelease and when we compare to other formulations