Superconductivity in Sr2RuO4-Sr3Ru2O7 eutectic crystals

Superconducting behavior has been observed in the Sr2RuO4-Sr3Ru2O7 eutectic system as grown by the flux-feeding floating zone technique. A supercurrent flows across a single interface between Sr2RuO4 and Sr3Ru2O7 areas at distances that are far beyond those expected in a conventional proximity scenario. The current-voltage characteristics within the Sr3Ru2O7 macrodomain, as extracted from the eutectic, exhibit signatures of superconductivity in the bilayered ruthenate. Detailed microstructural, morphological and compositional analyses address issues on the concentration and the size of Sr2RuO4 inclusions within the Sr3Ru2O7 matrix. We speculate on the possibility of inhomogeneous superconductivity in the eutectic Sr3Ru2O7 and exotic pairing induced by the Sr2RuO4 inclusions.Comment: Pages 4, figures 3, submitted to Phys. Rev. Let

Influence of Topological Edge States on the Properties of Al/Bi2Se3/Al Hybrid Josephson Devices

In superconductor-topological insulator-superconductor hybrid junctions, the barrier edge states are expected to be protected against backscattering, to generate unconventional proximity effects, and, possibly, to signal the presence of Majorana fermions. The standards of proximity modes for these types of structures have to be settled for a neat identification of possible new entities. Through a systematic and complete set of measurements of the Josephson properties we find evidence of ballistic transport in coplanar Al-Bi2Se3-Al junctions that we attribute to a coherent transport through the topological edge state. The shunting effect of the bulk only influences the normal transport. This behavior, which can be considered to some extent universal, is fairly independent of the specific features of superconducting electrodes. A comparative study of Shubnikov - de Haas oscillations and Scanning Tunneling Spectroscopy gave an experimental signature compatible with a two dimensional electron transport channel with a Dirac dispersion relation. A reduction of the size of the Bi2Se3 flakes to the nanoscale is an unavoidable step to drive Josephson junctions in the proper regime to detect possible distinctive features of Majorana fermions.Comment: 11 pages, 14 figure

Metabolic reprogramming promotes myogenesis during aging

Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia

Paramagnetic effect in YBaCuO grain boundary junctions

A detailed investigation of the magnetic response of YBaCuO grain boundary Josephson junctions has been carried out using both radio-frequency measurements and Scanning SQUID Microscopy. In a nominally zero-field-cooled regime we observed a paramagnetic response at low external fields for 45 degree asymmetric grain boundaries. We argue that the observed phenomenology results from the d-wave order parameter symmetry and depends on Andreev bound states.Comment: To be published in Phys. Rev.

A nosocomial outbreak of 2009 pandemic influenza A(H1N1) in a paediatric oncology ward in Italy, October – November 2009

A nosocomial outbreak of 2009 pandemic influenza A(H1N1), with eight confirmed cases, occurred in a paediatric oncology ward in Italy, in October/November 2009. The fact that one case was infected despite being isolated and without contact to a symptomatic patient, hints towards potential transmission through a health care worker (HCW) and underlines the importance of vaccination of HCW who are involved in the care of critically ill patients

An unprecedented case of cranial surgery in Longobard Italy (6th–8th century) using a cruciform incision

The Longobard necropolis of Castel Trosino dates from the 6th to the 8th century CE. Among the tombs excavated, the skull of an older female shows the first evidence of a cross-shaped bone modification on a living subject. Macroscopic, microscopic, and CT scan analyses revealed signs of at least two sets of scraping marks. Specifically, SEM analysis shows that perimortem bone-scraping traces are present on the skull. Both healed and non-healed defects suggest that the woman has received at least twice intentional bone modifications to address her condition. This is the first evidence of a cross-shaped therapeutic intervention on a living subject

Strong interconversion of non-polar phonons and Josephson plasma oscillations induced by equilibrium Josephson currents in high T_c superconductors

We analyze consequences of dynamical modulations of Josephson current by non-polar lattice mode in the Josephson junction barrier. In the high $T_c$ junctions, the effect of such modulations can be anomalously strong due to the proximity of the insulating barrier to the superconducting state. Accordingly, the interconversion of sound (as well as other non-polar phonons) and the Josephson plasma oscillations mediated by stationary Josephson currents, which may be present in the junction due to various reasons, becomes possible. We suggest that this effect can be employed for imaging of the stationary Josephson currents. Estimates of the effect are given.Comment: 11 RevTeX pages, no figure

Expression of orexin A and its receptor 1 in the rat epididymis.

The hypothalamic peptide orexin A (oxA) derives from the proteolytic cleavage of the precursor molecule prepro-orexin. It binds with the high affinity G-protein-coupled orexin receptor 1 (OX1R). Here, we report the detection of oxA and OX1R in the principal cells of the rat caudal epididymis by immunohistochemistry. Both oxA and OX1R immunolabelling showed cytoplasmic supranuclear localization, filling the apical portion of the cells. The expression of prepro-orexin and OX1R mRNA transcripts in the rat epididymis was assessed by reverse-transcriptase polymerase chain reaction, while the presence of both these proteins in the tissue was confirmed by Western blotting analysis. Our findings provide the evidence for the presence of oxA and OX1R in the rat epididymis, and demonstrate that both proteins are locally synthesised, thus suggesting a role for oxA in governing the fertilizing capability of the immature male gamete