2,862 research outputs found
Classification of book spreads in PG(5, 2)
We classify all line spreads in of a special kind, namely those which are \emph{book spreads}. We show that up to isomorphism there are precisely nine different kinds of book spreads and describe the automorphism groups which stabilize them. Most of the main results are obtained in two independent ways, namely theoretically and by computer. \en
Voltage-dependent Block of the Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channel by Two Closely Related Arylaminobenzoates
The gene defective in cystic fibrosis encodes a Cl- channel, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is blocked by diphenylamine-2-carboxylate (DPC) when applied extracellularly at millimolar concentrations. We studied the block of CFTR expressed in Xenopus oocytes by DPC or by a closely related molecule, flufenamic acid (FFA). Block of whole-cell CFTR currents by bath-applied DPC or by FFA, both at 200 ”M, requires several minutes to reach full effect. Blockade is voltage dependent, suggesting open-channel block: currents at positive potentials are not affected but currents at negative potentials are reduced. The binding site for both drugs senses ~40% of the electric field across the membrane, measured from the inside. In single-channel recordings from excised patches without blockers, the conductance was 8.0 ± 0.4 pS in symmetric 150 mM Cl^-. A subconductance state, measuring ~60% of the main conductance, was often observed. Bursts to the full open state lasting up to tens of seconds were uninterrupted at depolarizing membrane voltages. At hyperpolarizing voltages, bursts were interrupted by brief closures. Either DPC or FFA (50 ”M) applied to the cytoplasmic or extracellular face of the channel led to an increase in flicker at V_m =-100 mV and not at V_m = +100 mV, in agreement with whole-cell experiments. DPC induced a higher frequency of flickers from the cytoplasmic side than the extracellular side. FFA produced longer closures than DPC; the FFA closed time was roughly equal (~ 1.2 ms) at -100 mV with application from either side. In cell-attached patch recordings with DPC or FFA applied to the bath, there was flickery block at V_m = -100 mV, confirming that the drugs permeate through the membrane to reach the binding site. The data are consistent with the presence of a single binding site for both drugs, reached from either end of the channel. Open-channel block by DPC or FFA may offer tools for use with site-directed mutagenesis to describe the permeation pathway
Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility
Germline mutations in the von HippelâLindau disease (VHL) and succinate dehydrogenase subunit B (SDHB) genes can cause inherited phaeochromocytoma and/or renal cell carcinoma(RCC). Dysregulation of the hypoxia-inducible factor (HIF) transcription factors has been linked to VHL and SDHB-related RCC; both HIF dysregulation and disordered function of a prolyl hydroxylase domain isoform 3 (PHD3/EGLN3)-related pathway of neuronal apoptosis have been linked to the development of phaeochromocytoma. The 2-oxoglutarate-dependent prolyl hydroxylase enzymes PHD1 (EGLN2), PHD2 (EGLN1) and PHD3 (EGLN3) have a key role in regulating the stability of HIF-a subunits (and hence expression of the HIF-a transcription factors). A germline PHD2 mutation has been reported in association with congenital erythrocytosis and recurrent extra-adrenal phaeochromocytoma. We undertook mutation analysis of PHD1, PHD2 and PHD3 in two cohorts of patients with features of inherited phaeochromocytoma (nZ82) and inherited RCC (nZ64) and no evidence of germline mutations in known susceptibility genes. No confirmed pathogenic mutations were detected suggesting that mutations in these genes are not a frequent cause of inherited phaeochromocytoma or RCC
Studies of MCP-PMTs in the miniTimeCube neutrino detector
This report highlights two different types of cross-talk in the
photodetectors of the miniTimeCube neutrino experiment. The miniTimeCube
detector has 24 -anode Photonis MCP-PMTs Planacon XP85012,
totalling 1536 individual pixels viewing the 2-liter cube of plastic
scintillator
Teleology and Realism in Leibniz's Philosophy of Science
This paper argues for an interpretation of Leibnizâs claim that physics requires both mechanical and teleological principles as a view regarding the interpretation of physical theories. Granting that Leibnizâs fundamental ontology remains non-physical, or mentalistic, it argues that teleological principles nevertheless ground a realist commitment about mechanical descriptions of phenomena. The empirical results of the new sciences, according to Leibniz, have genuine truth conditions: there is a fact of the matter about the regularities observed in experience. Taking this stance, however, requires bringing non-empirical reasons to bear upon mechanical causal claims. This paper first evaluates extant interpretations of Leibnizâs thesis that there are two realms in physics as describing parallel, self-sufficient sets of laws. It then examines Leibnizâs use of teleological principles to interpret scientific results in the context of his interventions in debates in seventeenth-century kinematic theory, and in the teaching of Copernicanism. Leibnizâs use of the principle of continuity and the principle of simplicity, for instance, reveal an underlying commitment to the truth-aptness, or approximate truth-aptness, of the new natural sciences. The paper concludes with a brief remark on the relation between metaphysics, theology, and physics in Leibniz
Random template placement and prior information
In signal detection problems, one is usually faced with the task of searching
a parameter space for peaks in the likelihood function which indicate the
presence of a signal. Random searches have proven to be very efficient as well
as easy to implement, compared e.g. to searches along regular grids in
parameter space. Knowledge of the parameterised shape of the signal searched
for adds structure to the parameter space, i.e., there are usually regions
requiring to be densely searched while in other regions a coarser search is
sufficient. On the other hand, prior information identifies the regions in
which a search will actually be promising or may likely be in vain. Defining
specific figures of merit allows one to combine both template metric and prior
distribution and devise optimal sampling schemes over the parameter space. We
show an example related to the gravitational wave signal from a binary inspiral
event. Here the template metric and prior information are particularly
contradictory, since signals from low-mass systems tolerate the least mismatch
in parameter space while high-mass systems are far more likely, as they imply a
greater signal-to-noise ratio (SNR) and hence are detectable to greater
distances. The derived sampling strategy is implemented in a Markov chain Monte
Carlo (MCMC) algorithm where it improves convergence.Comment: Proceedings of the 8th Edoardo Amaldi Conference on Gravitational
Waves. 7 pages, 4 figure
The Critical Coupling Likelihood Method: A new approach for seamless integration of environmental and operating conditions of gravitational wave detectors into gravitational wave searches
Any search effort for gravitational waves (GW) using interferometric
detectors like LIGO needs to be able to identify if and when noise is coupling
into the detector's output signal. The Critical Coupling Likelihood (CCL)
method has been developed to characterize potential noise coupling and in the
future aid GW search efforts. By testing two hypotheses about pairs of
channels, CCL is able to identify undesirable coupled instrumental noise from
potential GW candidates. Our preliminary results show that CCL can associate up
to of observed artifacts with , to local noise sources,
while reducing the duty cycle of the instrument by . An approach
like CCL will become increasingly important as GW research moves into the
Advanced LIGO era, going from the first GW detection to GW astronomy.Comment: submitted CQ
Geo-neutrinos: A systematic approach to uncertainties and correlations
Geo-neutrinos emitted by heat-producing elements (U, Th and K) represent a
unique probe of the Earth interior. The characterization of their fluxes is
subject, however, to rather large and highly correlated uncertainties. The
geochemical covariance of the U, Th and K abundances in various Earth
reservoirs induces positive correlations among the associated geo-neutrino
fluxes, and between these and the radiogenic heat. Mass-balance constraints in
the Bulk Silicate Earth (BSE) tend instead to anti-correlate the radiogenic
element abundances in complementary reservoirs. Experimental geo-neutrino
observables may be further (anti)correlated by instrumental effects. In this
context, we propose a systematic approach to covariance matrices, based on the
fact that all the relevant geo-neutrino observables and constraints can be
expressed as linear functions of the U, Th and K abundances in the Earth's
reservoirs (with relatively well-known coefficients). We briefly discuss here
the construction of a tentative "geo-neutrino source model" (GNSM) for the U,
Th, and K abundances in the main Earth reservoirs, based on selected
geophysical and geochemical data and models (when available), on plausible
hypotheses (when possible), and admittedly on arbitrary assumptions (when
unavoidable). We use then the GNSM to make predictions about several
experiments ("forward approach"), and to show how future data can constrain - a
posteriori - the error matrix of the model itself ("backward approach"). The
method may provide a useful statistical framework for evaluating the impact and
the global consistency of prospective geo-neutrino measurements and Earth
models.Comment: 17 pages, including 4 figures. To appear on "Earth, Moon, and
Planets," Special Issue on "Neutrino Geophysics," Proceedings of Neutrino
Science 2005 (Honolulu, Hawaii, Dec. 2005
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