Preoptic Inputs and Mechanisms that Regulate Maternal Responsiveness

The preoptic area is a well-established centre for the control of maternal behaviour. An intact medial preoptic area (mPOA) is required for maternal responsiveness because lesion of the area abolishes maternal behaviours. Although hormonal changes in the peripartum period contribute to the initiation of maternal responsiveness, inputs from pups are required for its maintenance. Neurones are activated in different parts of the mPOA in response to pup exposure. In the present review, we summarise the potential inputs to the mPOA of rodent dams from the litter that can activate mPOA neurones. The roles of potential indirect effects through increased prolactin levels, as well as neuronal inputs to the preoptic area, are described. Recent results on the pathway mediating the effects of suckling to the mPOA suggest that neurones containing the neuropeptide tuberoinfundibular peptide of 39 residues in the posterior thalamus are candidates for conveying the suckling information to the mPOA. Although the molecular mechanism through which these inputs alter mPOA neurones to support the maintenance of maternal responding is not yet known, altered gene expression is a likely candidate. Here, we summarise gene expression changes in the mPOA that have been linked to maternal behaviour and explore the idea that chromatin remodelling during mother-infant interactions mediates the long-term alterations in gene expression that sustain maternal responding

Application of fiber optic sensors for vibration and ignition monitoring of a belt conveyor system

The belt conveyor serves as the main coal transport equipment in a coal mine and its safe operation is the lifeline of safety in coal mine production. However, traditionally, monitoring for ignition and for roller faults along the belt conveyor is problematic and so this paper puts forward an approach using radial grating vibration sensing technology for both belt conveyor roller vibration monitoring. This can then be used to predict the fault state in the roller and its position, using distributed optical fiber temperature measurement technology which can be used for hot spot monitoring'. This enables better fire prevention along the belt conveyor, which plays a positive and effective role in better mine safety

Enhancing the Sensitivity of SMS Fiber Sensors by the Use of High Refractive Index Coatings

This paper presents a study on the behavior of single-mode/multimode/single-mode sensors with diamond-like carbon coating of high refractive index. Spectra and response for different values of the external medium refractive index are recorded and analyzed

Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor

Previously, we have developed chemical sensors using fibre optic-based techniques for the detection of Cocaine, utilising molecularly imprinted polymers (MIPs) containing fluorescein moieties as the signalling groups. Here, we report the computational design of a fluorophore which was incorporated into a MIP for the generation of a novel sensor that offers improved sensitivity for Cocaine with a detection range of 1-100 micro-grams. High selectivity for Cocaine over a suite of known Cocaine interferants (25 micro-grams) was also demonstrated by measuring changes in the intensity of fluorescence signals received from the sensor

Computational Design and Fabrication of Optical Fibre Fluorescent Chemical Probes for the Detection of Cocaine

A rationally designed fluorophore has been developed and has been incorporated into molecularly imprinted polymers, as the basis of the design of a sensor. Its use has allowed the fabrication of two different designs of fibre-optic chemical probes using an approach based on the change of the emitted fluorescence being related to the concentration of the desired species that was present. A high sensitivity to the drug Cocaine was achieved with each of the probes, showing positive changes in the fluorescence signal achieved in response to 1–100 μ M solutions of the drug, in solution in aqueous cetonitrile. High sensitivity for Cocaine over a range of compounds was demonstrated for one of the probes (probe X) and detection of the drug is possible even in the presence of strong fluorescence interference. The work has also shown that probes of this type do not need to be discarded when used: re-use of probe X is possible using a straightforward washing procedure and the calibration performance was maintained

"All-fiber" tunable laser in the 2 mu m region, designed for CO2 detection

A stable and tunable thulium-doped “all-fiber” laser offering a narrow linewidth has been created specifically to act as a compact and simple laser source for gaseous CO2 detection. This has been done through a careful design to match the laser output wavelengths to the CO2 absorption lines at 1.875 and 1.997 μm, respectively. A sustainable output power of 11 mW over a tuning range of 7 nm has been obtained by using a combination of a high-reflective fiber Bragg grating with a low-reflective broadband mirror, fabricated at the end of the fiber through silver film deposition. The tuning was achieved using the relaxation-compression mechanism of the fiber Bragg grating, which formed an integral part of the laser resonant cavity. A fiber Bragg grating at 1.548 μm was utilized as a wavelength reference to monitor the tuning of the laser output over the 2 μm wavelength range with a simple and inexpensive interrogator, to avoid the use of an expensive optical spectrum analyzer and to facilitate “in-the-field” operation. This “all-fiber” laser resonator has been shown to be superior in terms of laser tuning range, output power, and linewidth compared to that created with a fiber Bragg grating pair, which was limited by the nonuniform strain transfer to both fiber Bragg gratings

The role of marine reserves in achieving sustainable fisheries (One contribution of 15 to a Theme Issue 'Fisheries: a Future?')

Many fishery management tools currently in use have conservation value. They are designed to maintain stocks of commercially important species above target levels. However, their limitations are evident from continuing declines in fish stocks throughout the world. We make the case that to reverse fishery declines, safeguard marine life and sustain ecosystem processes, extensive marine reserves that are off limits to fishing must become part of the management strategy. Marine reserves should be incorporated into modern fishery management because they can achieve many things that conventional tools cannot. Only complete and permanent protection from fishing can protect the most sensitive habitats and vulnerable species. Only reserves will allow the development of natural, extended age structures of target species, maintain their genetic variability and prevent deleterious evolutionary change from the effects of fishing. Species with natural age structures will sustain higher rates of reproduction and will be more resilient to environmental variability. Higher stock levels maintained by reserves will provide insurance against management failure, including risk-prone quota setting, provided the broader conservation role of reserves is firmly established and legislatively protected. Fishery management measures outside protected areas are necessary to complement the protection offered by marine reserves, but cannot substitute for it

The Historical Context of the Gender Gap in Mathematics

This chapter is based on the talk that I gave in August 2018 at the ICM in Rio de Janeiro at the panel on "The Gender Gap in Mathematical and Natural Sciences from a Historical Perspective". It provides some examples of the challenges and prejudices faced by women mathematicians during last two hundred and fifty years. I make no claim for completeness but hope that the examples will help to shed light on some of the problems many women mathematicians still face today

Variable Waist-Diameter Mach-Zehnder Tapered-Fiber Interferometer as Humidity and Temperature Sensor

In-line single-mode tapered-fiber Mach-Zehnder interferometer (MZI-SMTF) with average waist diameters (davg) of 4.05 and 2.89 μ m have been fabricated, and both the temperature and the humidity sensitivity of the surrounding media have been measured and compared. The humidity and the temperature were measured over the ranges from 0% to 90% and 28 °C to 40 °C, respectively. The stability of the system at 50%RH and 90%RH was investigated, while the temperature of the chamber was maintained at about 28 °C. The humidity and temperature sensitivity resolution values were 0.02 nm/%RH and 0.05 nm/0.1 °C for the MZI-SMTF-1 with an average waist diameter of 4.05 μ m , while they were 0.01 nm/%RH and 0.025 nm/0.1 °C for the MZI-SMTF-2 with an average waist diameter of 2.89 μ m

A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation

Parental behavior is pervasive throughout the animal kingdom and essential for species survival. However, the relative contribution of the father to offspring care differs markedly across animals, even between related species. The mechanisms that organize and control paternal behavior remain poorly understood. Using Sprague-Dawley rats and C57BL/6 mice, two species at opposite ends of the paternal spectrum, we identified that distinct electrical oscillation patterns in neuroendocrine dopamine neurons link to a chain of low dopamine release, high circulating prolactin, prolactin receptor-dependent activation of medial preoptic area galanin neurons, and paternal care behavior in male mice. In rats, the same parameters exhibit inverse profiles. Optogenetic manipulation of these rhythms in mice dramatically shifted serum prolactin and paternal behavior, whereas injecting prolactin into non-paternal rat sires triggered expression of parental care. These findings identify a frequency-tuned brain-endocrine-brain circuit that can act as a gain control system determining a species’ parental strategy