Entrepreneurial value creation: conceptualizing an exchange-based view of entrepreneurship

4sìopenPurpose: This paper proposes an Exchange-Based View of the value creation process. The Borrowing from marketing literature, the EBV advances that entrepreneurs and stakeholders are tied by exchange relationships, through which they co-create value by reciprocally making and realizing promises of value. Design/methodology/approach: Propositions are developed and offered to advance the role of exchange in the entrepreneurial value creation process. Findings: The authors conceptualize the enterprise as a system of exchange relationships between entrepreneurs and their stakeholders, thus proposing an exchange-based view of entrepreneurship. Originality/value: Such an account of the role of entrepreneurs and of their relationship with the stakeholders has meaningful implications for our understanding of the entrepreneurial tasks of opportunity recognition and exploitation.openPinelli M.; Lechner C.; Kraus S.; Liguori E.Pinelli, M.; Lechner, C.; Kraus, S.; Liguori, E

Environmental/occupational exposure to radon and non-pulmonary neoplasm risk: A review of epidemiologic evidence

Although Radon (Rn) is a known agent for lung cancer, the link between Rn exposure and other non-pulmonary neoplasms remains unclear. The aim of this review is to investigate the role of Rn in the development of tumors other than lung cancer in both occupational and environmental exposure. Particularly, our attention has been focused on leukemia and tumors related to brain and central nervous system (CNS), skin, stomach, kidney, and breast. The epidemiologic literature has been systematically reviewed focusing on workers, general population, and pediatric population. A weak increase in leukemia risk due to Rn exposure was found, but bias and confounding factors cannot be ruled out. The results of studies conducted on stomach cancer are mixed, although with some prevalence for a positive association with Rn exposure. In the case of brain and CNS cancer and skin cancer, results are inconclusive, while no association was found for breast and kidney cancers. Overall, the available evidence does not support a conclusion that a causal association has been established between Rn exposure and the risk of other non-pulmonary neoplasms mainly due to the limited number and heterogeneity of existing studies. To confirm this result, a statistical analysis should be necessary, even if it is now not applicable for the few studies available

Type 2 Diabetes Mellitus and COVID-19: A Narrative Review

The pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has involved more than one hundred million individuals, including more than two million deaths. Diabetes represents one of the most prevalent chronic conditions worldwide and significantly increases the risk of hospitalization and death in COVID-19 patients. In this review, we discuss the prevalence, the pathophysiological mechanisms, and the outcomes of COVID-19 infection in people with diabetes. We propose a rationale for using drugs prescribed in patients with diabetes and some pragmatic clinical recommendations to deal with COVID-19 in this kind of patient

Numerical investigation of oil injection in a Roots blower operated as expander

The adoption of positive displacement machines as expanders in Organic Rankine Cycles (ORCs) is increasingly common, especially in the low to medium power range. At the same time, these devices often serve as compressor in Vapor-Compression Refrigeration Systems. In both cases, the application of Computation Fluid Dynamics (CFD) to optimize such machines has become an integrated tool in the design process. As a consequence, several challenges associated with the numerical simulation have to be taken into account. For example, the modeling of the gap represents a challenge for the stability of the numerical analysis. The dynamic of the process, combined with deformations of the clearances and of the working chamber has to be considered with extra care. To raise the efficiency of the machine, oil is typically injected. Its numerical modeling imply an extra challenge in the simulation of the actual operation of the machine. The present work is mainly focused on the multi-phase nature of the flow, with a particular analysis of the lubricant oil injected. In this work, a two-lobe Roots blower operated as expander has been simulated with the open-source software OpenFOAM-v1812, using the SCORG-V5.2.2. This analysis highlights the areas that are affected the most by the oil presence in order to highlight the sealing effect it provides

Mechanisms of airfoil noise near stall conditions

The focus of this paper is on investigating the noise produced by an airfoil at high angles of attack over a range of Reynolds number Re≈2×10⁵–4×10⁵. The objective is not modeling this source of noise but rather understanding the mechanisms of generation for surface pressure fluctuations, due to a separated boundary layer, that are then scattered by the trailing edge. To this aim, we use simultaneous noise and surface pressure measurement in addition to velocimetric measurements by means of hot wire anemometry and time-resolved particle image velocimetry. Three possible mechanisms for the so-called “separation-stall noise” have been identified in addition to a clear link between far-field noise, surface pressure, and velocity fields in the noise generation

Full 3D numerical analysis of a twin screw compressor by employing open-source software

The push for having more reliable and efficient positive displacement machines (both compressors and expanders) for vapor compression and power generation (e.g., ORCs) applications has moved researchers to an always more spread employment of computational fluid dynamics (CFD). In particular, twin screw compressors, because of their high efficiency compared to other compressor types, have received interest over the last years. The numerical analysis of such machines is challenging: the deforming working chambers are very difficult to be correctly replicated. The relative motion of the rotors and the variation of the gaps during machine operation are few of the major difficulties in implementing reliable CFD models. A custom mesh generation algorithm is therefore often required for sumulating the machine operation. In this work, SCORG-V5.2.2 was used to generate the meshes of the deforming domain around rotating parts of the machines. The open-source software OpenFOAM-v1606+ is then employed to compute the flow field associated with the operation of the twin screw. The coupling of the two tools has been carried out in this work, applying the methodology to a twin screw machine

Idiopathic calcium nephrolithiasis with pure calcium oxalate composition: clinical correlates of the calcium oxalate dihydrate/monohydrate (COD/COM) stone ratio

Pure calcium oxalate is the most frequent type of idiopathic kidney stone composition. Fourier transform infrared spectroscopy (FT-IR) allows to detect the ratio of calcium oxalate dihydrate (COD) and monohydrate (COM) crystals in stones, but the clinical significance of this parameter remains uncertain. The objective of this observational study was to verify the association of clinical and laboratory parameters of kidney stone disease with COD/COM ratio in a group of 465 (322 M, age 46 ± 14) patients suffering from idiopathic calcium nephrolithiasis with pure calcium oxalate stones (≥ 97%). Each participant underwent a complete clinical examination, serum chemistry, 24-h urine collection for the determination of the profile of lithogenic risk, and had stones analyzed by FT-IR. Most (62%) of the stones had a COD/COM ratio ≤ 0.25, and the urine chemistry of the corresponding patients showed a low prevalence of urinary metabolic abnormalities. With increasing COD/COM ratio intervals (0–0.25, 0.26–0.50, 0.51–0.75, 0.76–1), a significant association was observed for the number of urological procedures, serum calcium, 24-h urinary calcium excretion, prevalence of hypercalciuria and relative calcium oxalate supersaturation, and a negative trend was detected for the age of the first stone episode (all p values < 0.05). A linear regression model showed that the only parameters significantly associated with COD/COM ratio were 24-h urinary calcium excretion (standardized β = 0.464, p < 0.001) and urine pH (standardized β = 0.103, p = 0.013). In pure calcium oxalate idiopathic stones, COD/COM ratio may reflect the presence of urinary metabolic risk factors, and represent a guide for the prescription of urinary analyses

Reference values and repeatability of inspiratory capacity for men and women aged 65–85

n/

Development of a continuous-flow anaerobic co-digestion process of olive mill wastewater and municipal sewage sludge

BACKGROUND: Olive mill wastewater (OMW) represents an environmental problem due to its high organic load and relevant concentration of phenolic compounds (PCs). OMW treatment and disposal represents a relevant challenge and cost for olive mills and multi-utilities in charge of waste management in Mediterranean countries. The goal of this study was to develop an anaerobic co-digestion (co-AD) process of OMW and sewage sludge (SwS) from municipal wastewater treatment. RESULTS: Different volumetric OMW:SwS ratios up to 100% OMW were fed in continuous 1.7-L bioreactors. The reactors fed with raw OMW (rOMW) performed better than those fed with OMW dephenolized by adsorption (dOMW). At a 23-day hydraulic retention time, the best performances were obtained in the reactor fed with 25% rOMW, with a 105% increase in methane yield in comparison to the 100% SwS test. At a 40-day hydraulic retention time, the reactor fed with 40% rOMW attained a 268 NLCH4/kgvolatile solids methane yield. The conversion of phenolic compoundsreached 70% when the hydraulic retention time was increased from 23 to 40 days. A cost\u2013benefit analysis indicated that both rOMW co-AD in existing digesters and phenolic compounds recovery from OMW followed by co-AD of dOMW can lead to relevant additional revenues for the multi-utilities in charge of wastewater management. CONCLUSION: This work proves that, using the existing network of SwS anaerobic digesters, it is feasible to co-digest the entire OMW production in regions characterized by intense olive oil production, thus attaining a relevant increase in methane production yield (a 144% increase in comparison to 100% SwS)