Nitramine smokeless propellant research

A transient ballistics and combustion model is derived to represent the closed vessel experiment that is widely used to characterize propellants. A computer program is developed to solve the time-dependent equations, and is applied to explain aspects of closed vessel behavior. In the case of nitramine propellants the cratering of the burning surface associated with combustion above break-point pressures augments the effective burning rate as deduced from the closed vessel experiment. Low pressure combustion is significantly affected by the ignition process and, in the case of nitramine propellants, by the developing and changing surface structure. Thus, burning rates deduced from the closed vessel experiment may or may not agree with those measured in the equilibrium strand burner. Series of T burner experiments are performed to compare the combustion instability characteristics of nitramine (HMX) containing propellants and ammonium perchlorate (AP)propellants. Although ash produced by more fuel rich propellants could have provided mechanical suppression, results from clean-burning propellants permit the conclusion that HMX reduces the acoustic driving

Pupil mobility, attainment and progress in secondary school

This paper is the second of two articles arising from a study of the association between pupil mobility and attainment in national tests and examinations in an inner London borough. The first article (Strand & Demie, 2006) examined the association of pupil mobility with attainment and progress during primary school. It concluded that pupil mobility had little impact on performance in national tests at age 11, once pupils’ prior attainment at age 7 and other pupil background factors such as age, sex, special educational needs, stage of fluency in English and socio-economic disadvantage were taken into account. The present article reports the results for secondary schools (age 11-16). The results indicate that pupil mobility continues to have a significant negative association with performance in public examinations at age 16, even after including statistical controls for prior attainment at age 11 and other pupil background factors. Possible reasons for the contrasting results across school phases are explored. The implications for policy and further research are discussed

Educational aspirations in inner city schools

The research aimed to assess the nature and level of pupils’ educational aspirations and to elucidate the factors that influence these aspirations. A sample of five inner city comprehensive secondary schools were selected by their Local Authority because of poor pupil attendance, below average examination results and low rates of continuing in full-time education after the age of 16. Schools were all ethnically mixed and co-educational. Over 800 pupils aged 12-14 completed a questionnaire assessing pupils’ experience of home, school and their peers. A sub-sample of 48 pupils selected by teachers to reflect ethnicity and ability levels in individual schools also participated in detailed focus group interviews. There were no significant differences in aspirations by gender or year group, but differences between ethnic groups were marked. Black African, Asian Other and Pakistani groups had significantly higher educational aspirations than the White British group, who had the lowest aspirations. The results suggest the high aspirations of Black African, Asian Other and Pakistani pupils are mediated through strong academic self-concept, positive peer support, a commitment to schooling and high educational aspirations in the home. They also suggest that low educational aspirations may have different mediating influences in different ethnic groups. The low aspirations of White British pupils seem to relate most strongly to poor academic self-concept and low educational aspirations in the home, while for Black Caribbean pupils disaffection, negative peers and low commitment to schooling appear more relevant. Interviews with pupils corroborated the above findings and further illuminated the factors students described as important in their educational aspirations. The results are discussed in relation to theories of aspiration which stress its nature as a cultural capacity

The limits of social class in explaining ethnic gaps in educational attainment

This paper reports an analysis of the educational attainment and progress between age 11 and age 14 of over 14,500 students from the nationally representative Longitudinal Study of Young People in England (LSYPE). The mean attainment gap in national tests at age 14 between White British and several ethnic minority groups were large, more than three times the size of the gender gap, but at the same time only about one-third of the size of the social class gap. Socio-economic variables could account for the attainment gaps for Black African, Pakistani and Bangladeshi students, but not for Black Caribbean students. Further controls for parental and student attitudes, expectations and behaviours indicated minority ethnic groups were on average more advantaged on these measures than White British students, but this was not reflected proportionately in their levels of attainment. Black Caribbean students were distinctive as the only group making less progress than White British students between age 11 and 14 and this could not be accounted for by any of the measured contextual variables. Possible explanations for the White British-Black Caribbean gap are considered

Photometric and Spectroscopic Analysis of Cool White Dwarfs with Trigonometric Parallax Measurements

A photometric and spectroscopic analysis of 152 cool white dwarf stars is presented. The discovery of 7 new DA white dwarfs, 2 new DQ white dwarfs, 1 new magnetic white dwarf, and 3 weak magnetic white dwarf candidates, is reported, as well as 19 known or suspected double degenerates. The photometric energy distributions, the Halpha line profiles, and the trigonometric parallax measurements are combined and compared to model atmosphere calculations to determine the effective temperature and the radius of each object, and also to constrain the atmospheric composition. New evolutionary sequences with C/O cores with thin and thick hydrogen layers are used to derive masses and ages. We confirm the existence of a range in Teff between 5000 and 6000K where almost all white dwarfs have H-rich atmospheres. There is little evidence for mixed H/He dwarfs, with the exception of 2 He-rich DA stars, and 5 C2H white dwarfs which possibly have mixed H/He/C atmospheres. The DQ sequence terminates near 6500K, below which they are believed to turn into C2H stars. True DC stars slightly above this temperature are found to exhibit H-like energy distributions despite the lack of Halpha absorption. Attempts to interpret the chemical evolution show the problem to be complex. Convective mixing is necessary to account for the non-DA to DA ratio as a function of temperature. The presence of helium in cool DA stars, the existence of the non-DA gap, and the peculiar DC stars are also explained in terms of convective mixing, although our understanding of how this mechanism works needs to be revised. The oldest object in our sample is about 7.9 Gyr or 9.7 Gyr old depending on whether thin or thick hydrogen layer models are used. The mean mass of our sample is 0.65 +/- 0.20 Msun.Comment: Accepted by ApJ Suppl (~April 2001); 79 pages incl. 25 figure

A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee

Objective To compare the safety and efficacy of a single intra-articular (IA) injection of a new cross-linked hyaluronic acid product, Gel-200, with phosphate buffered saline (PBS, control) in a multi-center randomized controlled trial in patients with symptomatic osteoarthritis (OA) of the knee. Design Patients were randomized 2:1 to receive a single injection of Gel-200 or PBS, after joint aspiration. The primary measure of effectiveness was Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscores by 100-mm Visual Analog Scale (VAS); secondary outcomes included: total WOMAC, physical function, and stiffness subscores; patient and physician global assessments of disease activity, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT–OARSI) strict responders, as well as safety of Gel-200. Results Of 379 patients randomized, safety was evaluated in 377 and efficacy in 375 (98.9% randomized) in the intent-to-treat population. Effectiveness of Gel-200 by WOMAC pain subscores was statistically significant at week 13 (P = 0.037). Mean improvements from baseline in WOMAC pain subscores consistently favored Gel-200 at each visit. Effectiveness of Gel-200 treatment was statistically significant over weeks 3–13 by WOMAC total score, physical function, and physician global evaluations (P \u3c 0.05). The number of “strict” OMERACT–OARSI responders was statistically significant from weeks 6 to 13 (P = 0.022). Adverse events were not significantly different between treatment groups, including serious adverse events considered related to study treatment. Conclusions This trial demonstrated that a single injection of Gel-200 was well tolerated and relieved pain associated with symptomatic OA of the knee over 13 weeks. Trial registration number ClinicalTrials.gov NTC 00449696

Use of Non-Steroidal Anti-Inflammatory Drugs That Elevate Cardiovascular Risk: An Examination of Sales and Essential Medicines Lists in Low-, Middle-, and High-Income Countries

PMCID: PMC3570554This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Biodegradation of the Alkaline Cellulose Degradation Products Generated during Radioactive Waste Disposal.

The anoxic, alkaline hydrolysis of cellulosic materials generates a range of cellulose degradation products (CDP) including α and β forms of isosaccharinic acid (ISA) and is expected to occur in radioactive waste disposal sites receiving intermediate level radioactive wastes. The generation of ISA's is of particular relevance to the disposal of these wastes since they are able to form complexes with radioelements such as Pu enhancing their migration. This study demonstrates that microbial communities present in near-surface anoxic sediments are able to degrade CDP including both forms of ISA via iron reduction, sulphate reduction and methanogenesis, without any prior exposure to these substrates. No significant difference (n = 6, p = 0.118) in α and β ISA degradation rates were seen under either iron reducing, sulphate reducing or methanogenic conditions, giving an overall mean degradation rate of 4.7×10−2 hr−1 (SE±2.9×10−3). These results suggest that a radioactive waste disposal site is likely to be colonised by organisms able to degrade CDP and associated ISA's during the construction and operational phase of the facility