Geomechanical assessment of the stability of internal dump on worked up foundation of the open pit edge

Purpose. Evaluation of the stability of the internal rock dump on the worked up pit edge of Pervomaiskiy quarry of SevGOK taking into consideration geometry, rock physical and mechanical properties and seismic impacts from blasting operations. Methodology. To study geomechanical stability of the pit edge while mining operations, the data of engineering and geological surveys, technological schemes for conducting open mining operations, surveying data were used. For numerical simulation of the internal dump slope stability and the pit edge slope stability, the finite element analysis software Phase2 by Rocscience Inc. is used. Findings. Geomechanical assessment of the stability of the quarry internal dump constructed on the southwestern pit edge taking into consideration complex structure, rock properties and seismic effects from blasting operations has been carried out. For a three-tier dump, safety factors were calculated taking into consideration seismic impacts from blasting operations at a quarry in the range of 0.00625-0.1 g, which corresponds to a magnitude of 3-7 earthquake. The potential effect of extinguished underground mine workings on the stability of the internal dump was assessed. Originality. It is established that the maximum potential displacement of the massif near the extinguished underground workings in the pit edge reaches the value Uxy = 7.6-22.0 m, and a large-scale subsidence area of rocks up to 50-60 m in diameter and up to 4 m in depth can form on the surface of the internal dump. Seismic impacts from blasing operation at the quarry can be as a trigger factor for geomechanical disturbances. Practical value. The results of numerical simulation of the stability of internal dump on worked up the pit edge foundation can be considered in mining development projects to ensure the safety of the open mining technology and internal dumping operations

ANTISYNTHETASE SYNDROME: COURSE OF A RARE DISEASE ON EXAMPLE OF CLINICAL CASE

Systemic disorders of connective tissue refer to rare and poorly studied diseases. This group of diseases associated with the variable course and makes it interesting for either medical scientists and researchers or practitioner. Herein we report a case of antisynthetase syndrome with interstitial lung disease complicated by pulmonary thromboembolism. The patient is 71 year old female, who suffered from severe dyspnea, dry cough, intermittent wheezing. Also she had dry eyes, dry mouth, muscle weakness and intermittent pain in large joints, and low grade fever. Physical examination revealed a characteristic heliotrope eye rash, V sign, «mechanic’s hand», peripheral muscles atrophy, dry eyes and mouth, fine crackles to auscultation in basal parts of lungs, soft S1 and S2 heart sounds. Her biochemical profile showed increased creatinekinase, LDH, AsAT, and AlAT Her immunology results were positive to ANA, anti-ds-DNA, anti-ss-A, anti-ss-B and anti- Jo-1 autoantibodies. Based on the obtained data, antisynthetase syndrome was established. It was detected, that progressive dyspnea had been caused by interstitial lung disease and pulmonary thromboembolism. It was confirmed by chest CT-scan and pulmonary angiography. Treatment in this case is mainly symptomatic. It was prescribed glucocorticoids, immunosuppressant, and anticoagulants. This case illustrates the course of the antisynthetase overlap syndrome and difficulties of it management due to the lack of treatment standards and reliable data of the medicine effectiveness

A device for automatic diagnostication of analog electric control devices based industrial controller Logo

Запропоновано структуру та програму функціонування мікропроцесорного пристрою діагностування автоматичних аналогових керуючих пристроїв електропривода на базі промислового контролера LOGO.Предложено структуру и программу функционирования микропроцессорного устройства диагностирования автоматических аналоговых управляющих устройств электропривода на базе промышленного контроллера LOGO.The structure and operation of analog electric control devices microprocessor unit program automatic diagnosis based industrial controller LOGO

Biochemical composition of urine in rats with developed Guerin’s carcinoma and administration of cisplatin

The kidneys are very sensitive to the action not only of exogenous chemicals but also the action of compounds of endogenous origin, produced by changes in the normal metabolic processes and the development of various pathologies. Thus, tumour development has a significant impact on overall homeostasis of the body. Research into the condition of the kidneys subject to growth of tumours when cisplatin is administered is a major issue in both medical and biochemical aspects. We investigated the renal function, electrolyte composition of the blood and urinary excretion of electrolytes and individual plasma osmolarity in models of tumour growth in rats subject to introduction of cisplatin. We found that development of Guerin’s carcinoma T8 and the administration of cisplatin causes kidney damage in rats. This leads to an increase in the relative weight of the kidneys, proteinuria, and changes in activity of γ-glutamyl-transferase and lactate dehydrogenase in the kidney homogenate and urine, lower relative reabsorption and glomerular filtration. The development of Guerin’s carcinoma and administration of cisplatin in the blood and urine of rats led to a decrease in diuresis per minute by 20–60%, creatinine clearance by 50–70% and reduction in the relative water reabsorption in the renal tubules to 26% compared with the control. The administration of cisplatin led to a threefold increase in the concentration of protein, twofold increase in the concentration of albumin and sevenfold increase in the concentration of glucose in the rats’urine. In the case of rats with lesions and renal diseases (including different types of tumours) a reduction in the output of urine per minute, creatinine clearance and water reabsorption in the renal tubules was observed, indicating significant damage to the concentration and filtration functions of the kidneys. Tumour growth led to the development of hypokalemia, hyponatremia and hypochloridemia, which are major and early signs of acute renal failure. The introduction of cisplatin led to damage to the kidneys and partly normalized these indicators, as evidenced by biochemical and morphological studies. Our study shows that there is a pressing need for use of drugs which protect the kidneys when cisplatin is administered

Kinematics of reference height network on the territory of Rivne NPP

Rivne Nuclear Power Plant (NPP) is located in western Ukraine. Construction of the station began in 1976. Totally four power generating units are operating on the station. Complicated geological conditions and display of man-made karst led to the need for monitoring of sediments and deformations on Rivne NPP. Since 1984 on the Rivne NPP there were conducted geodetic observations on the conditions of height reference network consisting of nine deep fixed reference points, which are installed in basaltic rocks. Totally 110 cycles of observations were conducted. The heights of fixed reference points were determined by leveling of I-st class. It is necessary to assess the kinematics of the reference height network and implement zoning of station territory according to a speed of inclination of the earth's surface. An average annual rates of displacement which appear as a linear trend weredetermined on the results of measurements for each fixed reference point by the least squares method. Excluding these values the vertical displacements of fixed reference points were derived and only the periodic component that is changing according to the periodic law remained present there. For each fixed reference point it was determined amplitude and optimum oscillation period and the coefficients of regression equations. Using the annual velocity of displacement of fixed reference points it was done the zoning of the Rivne NPP. There were allocated areas, which were characterized by different rates of inclinations and frequency of oscillations

Kinematics of Reference Height Network on the Territory of Rivne Npp

Rivne Nuclear Power Plant (NPP) is located in western Ukraine. Construction of the station began in 1976. Totally four power generating units are operating on the station. Complicated geological conditions and display of man-made karst led to the need for monitoring of sediments and deformations on Rivne NPP. Since 1984 on the Rivne NPP there were conducted geodetic observations on the conditions of height reference network consisting of nine deep fixed reference points, which are installed in basaltic rocks. Totally 110 cycles of observations were conducted. The heights of fixed reference points were determined by leveling of I-st class. It is necessary to assess the kinematics of the reference height network and implement zoning of station territory according to a speed of inclination of the earth's surface. An average annual rates of displacement which appear as a linear trend weredetermined on the results of measurements for each fixed reference point by the least squares method. Excluding these values the vertical displacements of fixed reference points were derived and only the periodic component that is changing according to the periodic law remained present there. For each fixed reference point it was determined amplitude and optimum oscillation period and the coefficients of regression equations. Using the annual velocity of displacement of fixed reference points it was done the zoning of the Rivne NPP. There were allocated areas, which were characterized by different rates of inclinations and frequency of oscillations

Regional monitoring of the urinary tract infections etiological spectrum pathogens in the child population in Chernivtsi region: dynamic changes, age, gender, administrative and territorial characteristics

Microbiological monitoring of the uropathogens is an effective «tool» for urinary tract infectious and inflammatory diseases treatment quality improvement. The aim of the article is to determine the range of the urinary tract infectious-inflammatory diseases etiological spectrum groups of pathogens in the child population in Chernivtsi region. Materials and methods. The etiologic spectrum of uropathogens identified in the urine samples of 657 patients who were provided with a specialized medical care in the Nephrology Department of the «Municipal Children’s Clinical Hospital», Chernivtsi (2014–2015) was analyzed in order to dynamically control the possible changes of the «urinary tract infections» (UTI) regional etiological structure and antibiotic resistance of pathogens; identification of age and gender differences of urine microbial diversity in the child population in Chernivtsi region (2014–2015) compared with the monitoring data for the 2009–2013 period. Results. A significant difference has been found in the etiological structure of the urine microbial diversity in children with infectious and inflammatory diseases of the urinary tract (Gram-positive cocci – p < 0.05; Enterobacteria – p < 0.01; resident microflora – p < 0.01) in comparison with uropathogens extracted in children with urinary tract noninfectious diseases. Administrative and territorial differences have been registered in etiological structure of the urine microbial diversity in children living in the urban areas (p < 0.01) from their peers living in the rural areas. Conclusions. The regional monitoring data showed changes of the urine resident microflora (p < 0.01) without significant changes of etiological spectrum of the UTI pathogens in examined children (0–18 years old) with urinary tract infectious and inflammatory diseases during 2009–2015 in Chernivtsi region. At the same time it as a matter of concern a significant increase in the proportion of «negative results» (no growth) in the urine bacteriological analysis (p < 0.01), which might indirectly indicate the «uncontrolled» use of antibiotics among children in the region

Регіональний моніторинг етіологічного спектра збудників інфекцій сечової системи серед дитячого населення Чернівецької області: динамічні зміни, вікові, гендерні та адміністративно-територіальні особливості

Microbiological monitoring of the uropathogens is an effective «tool» for urinary tract infectious and inflammatory diseases treatment quality improvement.The aim of the article is to determine the range of the urinary tract infectious-inflammatory diseases etiological spectrum groups of pathogens in the child population in Chernivtsi region.Materials and methods. The etiologic spectrum of uropathogens identified in the urine samples of 657 patients who were provided with a specialized medical care in the Nephrology Department of the «Municipal Children’s Clinical Hospital», Chernivtsi (2014–2015) was analyzed in order to dynamically control the possible changes of the «urinary tract infections» (UTI) regional etiological structure and antibiotic resistance of pathogens; identification of age and gender differences of urine microbial diversity in the child population in Chernivtsi region (2014–2015) compared with the monitoring data for the 2009–2013 period.Results. A significant difference has been found in the etiological structure of the urine microbial diversity in children with infectious and inflammatory diseases of the urinary tract (Gram-positive cocci – p &lt; 0.05; Enterobacteria – p &lt; 0.01; resident microflora – p &lt; 0.01) in comparison with uropathogens extracted in children with urinary tract noninfectious diseases. Administrative and territorial differences have been registered in etiological structure of the urine microbial diversity in children living in the urban areas (p &lt; 0.01) from their peers living in the rural areas.Conclusions. The regional monitoring data showed changes of the urine resident microflora (p &lt; 0.01) without significant changes of etiological spectrum of the UTI pathogens in examined children (0–18 years old) with urinary tract infectious and inflammatory diseases during 2009–2015 in Chernivtsi region. At the same time it as a matter of concern a significant increase in the proportion of «negative results» (no growth) in the urine bacteriological analysis (p &lt; 0.01), which might indirectly indicate the «uncontrolled» use of antibiotics among children in the region.Микробиологический мониторинг уропатогенов является действенным «инструментом» в повышении качества лечения инфекционно-воспалительных заболеваний мочевой системы.Цель работы – установить динамику этиологического спектра групп возбудителей инфекционно-воспалительных заболеваний мочевой системы у детского населения Черновицкой области.Материалы и методы. Проведён анализ этиологического спектра уропатогенов, идентифицированных в 657 образцах мочи пациентов, которым оказывалась специализированная медицинская помощь в нефрологическом отделении КГУ «Городская детская клиническая больница» г. Черновцы (2014–2015 гг.) с целью динамического контроля региональной этиологической структуры групп возбудителей «инфекций мочевой системы» (ИМС); выявления возрастных и гендерных различий микробного «пейзажа» мочи детского населения Черновицкой области (2014–2015 гг.) в сравнении с полученными ранее данными мониторинга за период 2009–2013 гг.Результаты. Выявлены достоверные отличия в этиологической структуре уропатогенов, выделенных в моче пациентов с инфекционно-воспалительными заболеваниями мочевыделительной системы (грамположительные кокки – p &lt; 0,05; энтеробактерии – p &lt; 0,01; резидентная микрофлора – p &lt; 0,01) в сравнении с уропатогенами при неинфекционных заболеваниях мочевыделительной системы детей.Зарегистрированы административно-территориальные отличия в этиологической структуре микробного «пейзажа» мочи у пациентов детского возраста – жителей городских населенных пунктов (p &lt; 0,01) от их сверстников, проживающих в сельской местности.Выводы. Данные регионального мониторинга показали, что в течение 2009–2015 гг. наблюдения среди детского населения (0–18 лет) Черновицкой области с инфекционно-воспалительными заболеваниями мочевыделительной системы произошли изменения в резидентной микрофлоре мочи (p &lt; 0,01) без существенных изменений в этиологическом спектре штаммов возбудителей ИМС. В то же время вызывает беспокойство достоверное увеличение доли «отрицательных результатов» (отсутствует рост) в бактериологических исследованиях мочи (p &lt; 0,01), что косвенно может свидетельствовать о «неконтролируемом» применении антибактериальных препаратов среди детского населения региона. Мікробіологічний моніторинг уропатогенів – дієвий «інструмент» у підвищенні якості лікування інфекційно-запальних захворювань сечової системи.Мета роботи – встановити динаміку етіологічного спектра груп збудників інфекційно-запальних захворювань сечової системи в дитячого населення Чернівецької області.Матеріали та методи. Здійснили аналіз етіологічного спектра уропатогенів, що ідентифіковані у 657 зразках сечі пацієнтів, яким надавалась спеціалізована медична допомога в нефрологічному відділенні КМУ «Міська дитяча клінічна лікарня» м. Чернівці (2014–2015 рр.), з метою динамічного контролю щодо можливих змін у регіональній етіологічній структурі груп збудників «інфекцій сечової системи» (ІСС); виявлення вікових і гендерних відмінностей мікробного «пейзажу» сечі в дитячого населення Чернівецької області (2014–2015 рр.) у порівнянні з отриманими даними моніторингу за період 2009–2013 років.Результати. Виявлена вірогідна різниця в етіологічній структурі мікробного «пейзажу» сечі в пацієнтів дитячого віку з інфекційно-запальними захворюваннями сечовидільної системи (грампозитивні коки – p &lt; 0,05; ентеробактерії – p &lt; 0,01; резидентна мікрофлора – p &lt; 0,01) порівняно з виділеними уропатогенами при неінфекційних захворюваннях сечовидільної системи дітей.Зареєстровані адміністративно-територіальні відмінності в етіологічній структурі мікробного «пейзажу» сечі в пацієнтів дитячого віку – мешканців міських населених пунктів (p &lt; 0,01) від їхніх однолітків, які проживають у сільській місцевості.Висновки. Дані регіонального моніторингу показали: протягом 2009–2015 рр. спостереження серед дітей (0–18 років) Чернівецької області з інфекційно-запальними захворюваннями сечовидільної системи відбулись зміни у резидентній мікрофлорі сечі (p &lt; 0,01) без суттєвих змін в етіологічному спектрі штамів збудників ІСС. Водночас викликає занепокоєння вірогідне збільшення частки «негативних результатів» (відсутній ріст) у бактеріологічних дослідженнях сечі (p &lt; 0,01), що опосередковано може свідчити про «неконтрольоване» застосування антибактеріальних препаратів серед дитячого населення регіону