ВЛИЯНИЕ ВИЧ-ИНФЕКЦИИ И ГЕНДЕРНЫХ РАЗЛИЧИЙ НА ФОРМИРОВАНИЕ ЛЕТАЛЬНОСТИ ПАЦИЕНТОВ ПРОТИВОТУБЕРКУЛЕЗНОГО СТАЦИОНАРА

591 lethal cases among patients of TB dispensary were analyzed with relevance to gender and HIV status; the part of patients with TB/HIV co-infection made 38.4% with absolute prevalence of men among those died (82.2%). It has been found out that those died due to HIV infection suffered mostly from disseminated and miliary tuberculosis  and HIV negative patients had fibrous cavernous and infiltrate tuberculosis. No impact of gender on the form of pulmonary tuberculosis was detected in HIV positive patients, and infiltrate form of tuberculosis was confidently the most common cause of death in female HIV negative patients. Generalized tuberculosis confidently developed more often in HIV positive patients, male patients had more severe lesions with the higher frequency of meningocephalites. The cause of death in those with TB/HIV infection was the progressing disease with no antiretroviral therapy  in the majority of cases regardless of gender.Проведен  анализ  591 случая летального исхода у пациентов  противотуберкулезного диспансера в зависимости  от гендерной принадлежности и ВИЧ-инфекции, доля пациентов  с сочетанием  ВИЧ/туберкулез составила  38,4%, с абсолютным  преобладанием  мужчин среди умерших (82,2%). Выявлено, что у лиц, умерших от ВИЧ-инфекции, чаще регистрировался диссеминированный и милиарный  туберкулез, а у пациентов  без ВИЧ-инфекции – фиброзно-кавернозный и инфильтративный туберкулез.  При этом влияния гендерных различий  на формирование форм легочного туберкулеза  у больных с ВИЧ-инфекцией не выявлено, а у пациентов без ВИЧ-инфекции женского пола достоверно чаще причиной смерти выступал инфильтративный туберкулез. Генерализация туберкулеза достоверно чаще развивалась у пациентов с ВИЧ-инфекцией, у лиц мужского пола варианты поражения были более тяжелыми с большей частотой менингоэнцефалитов. У лиц с коинфекцией причиной смерти являлось прогрессирование заболевания на фоне отсутствия антиретровирусной терапии в подавляющем большинстве случаев независимо от гендерной принадлежности

The Compact Linear Collider (CLIC) - 2018 Summary Report

The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear $e^+e^-$ collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years

INFLUENCE OF IMMUNOLOGICAL DISORDERS ON AN OUTCOME FOR THE FIRST TIME DIAGNOSED INFILTRATIVE TUBERCULOSIS IN SOCIALLY SAFE PATIENTS

The assessment of immunological indicators in 76 first time diagnosed infiltrative tuberculosis of lungs in socially safe patients prior to treatment and in 2 months of chemotherapy was carried out. It is revealed that immunological disorders are connected with efficiency of tuberculosis treatment . It can be criterion of quality of provided chemotherapy. The activation of cell immunity, stimulation of phagocytosis activity of neutrophils would contribute for effective treatment of tuberculosis

Dynamics of Main Indicators of the Epidemiological Situation on Tuberculosis in the Omsk Region

The aim of the study is to analyze the dynamics of the main epidemiological indicators that characterize the epidemiological situation of tuberculosis in the Omsk Region from 2001 to 2015. Material and methods. For the analysis were used for reporting forms: № 8 («Information on active tuberculosis», № 33 («Information on tuberculosis patients»), № 61 («Information on contingents of patients with HIV infection»). The statistical processing was carried out with the help of the Microsoft Excel software package, applied the method of analyzing the dynamic series with the calculation of the rates of growth/decrease in epidemiological indicators and the determination of the average geometric index for aligned series, regression analysis. Results. It has been established that in 2009 in the Omsk Region, the main indicators that characterize the epidemiological situation of tuberculosis have decreased: morbidity (by 25.4%), prevalence (by 55.5%), mortality (by 53.1%). At the same time, there was an increase in the incidence of multidrug-resistant disease, an increase in the incidence of HIV infection and HIV-associated tuberculosis. Conclusions. The obtained results allow to assume the possibility of developing a new period of worsening of the epidemiological situation of tuberculosis, characterized by high mortality and a further growth of the reservoir of infection in the region

IMPACT OF HIV INFECTION AND GENDER ON THE MORTALITY IN THE PATIENTS OF TUBERCULOSIS IN-PATIENT UNIT

591 lethal cases among patients of TB dispensary were analyzed with relevance to gender and HIV status; the part of patients with TB/HIV co-infection made 38.4% with absolute prevalence of men among those died (82.2%). It has been found out that those died due to HIV infection suffered mostly from disseminated and miliary tuberculosis  and HIV negative patients had fibrous cavernous and infiltrate tuberculosis. No impact of gender on the form of pulmonary tuberculosis was detected in HIV positive patients, and infiltrate form of tuberculosis was confidently the most common cause of death in female HIV negative patients. Generalized tuberculosis confidently developed more often in HIV positive patients, male patients had more severe lesions with the higher frequency of meningocephalites. The cause of death in those with TB/HIV infection was the progressing disease with no antiretroviral therapy  in the majority of cases regardless of gender

Power absorption in the plasma ion source of a helicon type

The article presents the solution of the power absorption problem in the helicon-type plasma ion source. Ion source used now as an injector of the IAP NASU nuclear microprobe was chosen for calculations. Results were obtained for hydrogen and helium plasma. Cylindrical plasma source is placed in the external longitudinal (along the cylinder axis) uniform magnetic field. Working frequency of the source w is in the range of wci <w <wce <wpe and w = 2 ×p × f (rad/s) ; f = 27,12 MHz . The values of the uniform external magnetic field, when the power absorption is maximum, were obtained for various plasma densities