135 research outputs found
Incomplete Excision of Cutaneous Squamous Cell Carcinoma; Systematic Review of the Literature
The treatment of choice for cutaneous squamous cell carcinoma is complete surgical excision. Incomplete excision of cutaneous squamous cell carcinoma has an increased risk of local recurrence, deep subclinical progression, and metastasis. This study aimed to investigate the proportion and risk factors of incomplete excised cutaneous squamous cell carcinoma. A systematic review of the literature was performed. Incomplete excision rates for cutaneous squamous cell carcinoma ranged from 0.4% to 35.7%. The pooled incomplete excision risk estimate was 13% (95% confidence interval 9-17%). Risk factors noted in more than one study for incomplete excision included tumor depth and size, type of operator, head and neck localization, and former incomplete excision. We found an overall incomplete excision rate of 13% for cutaneous squamous cell carcinoma. Risk factors should be taken into account in the management of cutaneous squamous cell carcinoma surgical treatment
Immune checkpoint inhibitor therapy in HIV-associated Merkel cell carcinoma: A case series of 3 patients.
Rotation in Event Horizon Telescope Movies
The Event Horizon Telescope (EHT) has produced images of M87* and Sgr A*, and
will soon produce time sequences of images, or movies. In anticipation of this,
we describe a technique to measure a rotation rate, or pattern speed
, from movies using an autocorrelation technique. We validate the
technique on Gaussian random field models with a known rotation rate and apply
it to a library of synthetic images of Sgr A* based on general relativistic
magnetohydrodynamics (GRMHD) simulations. We predict that EHT movies will have
degree per , which is of order
of the Keplerian orbital frequency in the emitting region. We can plausibly
attribute the slow rotation seen in our models to the pattern speed of
inward-propagating spiral shocks. We also find that depends strongly
on inclination. Application of this technique will enable us to compare future
EHT movies with the clockwise rotation of Sgr A* seen in near-infrared flares
by GRAVITY. Pattern speed analysis of future EHT observations of M87* and Sgr
A* may also provide novel constraints on black hole inclination and spin, as
well as an independent measurement of black hole mass
Successful Treatment of Protein-Losing Gastroenteropathy with Steroid Pulse and Immunosuppressive Therapies in a Patient with Sjƶgren Syndrome
We report the case of a 59-year-old female who developed facial edema together with hypoproteinemia. On the basis of 99mTc-human serum albumin scintigraphy and a1-antitrypsin clearance, she was diagnosed with protein-losing gastroenteropathy. Furthermore, she was diagnosed with Sjƶgren syndrome on the basis of eye and oral dryness, positive result with anti-SSA antibody, and salivary gland biopsy. Her symptoms improved with the use of immunosuppressive agents following steroid pulse therapy. Therefore, steroid pulse therapy and immunosuppressive agents should be considered as possible effective treatment strategies for protein-losing gastroenteropathy associated with autoimmune diseases
Changes in reflectin protein phosphorylation are associated with dynamic iridescence in squid
Author Posting. Ā© The Author(s), 2009. This is the author's version of the work. It is posted here by permission of The Royal Society for personal use, not for redistribution. The definitive version was published in Journal of The Royal Society Interface 6 (2010): 549-560, doi:10.1098/rsif.2009.0299.Many cephalopods exhibit remarkable dermal iridescence, a component of their complex,
dynamic camouflage and communication. In the species Euprymna scolopes, the light-organ iridescence
is static and is due to reflectin protein-based platelets assembled into lamellar thin-film
reflectors called iridosomes, contained within iridescent cells called iridocytes. Squid in the
family Loliginidae appear to be unique in that the dermis possesses a dynamic iridescent component,
with reflective, colored structures that are assembled and disassembled under the control of
the muscarinic cholinergic system and the associated neurotransmitter acetylcholine (Mathger et
al. 2004). Here we present the sequences and characterization of three new members of the reflectin
family associated with the dynamically changeable iridescence in Loligo and not found in
static Euprymna iridophores. In addition, we show that application of genistein, a protein tyrosine
kinase inhibitor, suppresses acetylcholine- and calcium-induced iridescence in Loligo. We
further demonstrate that two of these novel reflectins are extensively phosphorylated in concert
with the activation of iridescence by exogenous acetylcholine. This phosphorylation and the correlated
iridescence can be blocked with genistein. Our results suggest that tyrosine phosphorylation
of reflectin proteins is involved in the regulation of dynamic iridescence in Loligo.We gratefully acknowledge support from Anteon contract F33615-03-D-5408 to the Marine
Biological Laboratory, Woods Hole, MA and grant # W911NF-06-1-0285 from the Army
Research Office to D.E.M
Stres na radu i zdravlje medicinskih sestara u jedinicama intenzivne njege u Srbiji
The aim of this study was to identify and analyse professional stressors, evaluate the level of stress in nurses in Intensive Care Units (ICU), and assess the correlation between the perception of stress and psychological and somatic symptoms or diseases shown by nurses. The research, designed as a crosssectional study, was carried out in the Intensive Care Units (ICU), in health centres in Serbia. The sample population encompassed 1000 nurses. Expanded Nursing Stress Scale (ENSS) was used as the research instrument. ENSS revealed a valid metric characteristic within our sample population. Nurses from ICUs rated situations involving physical and psychological working environments as the most stressful ones, whereas situations related to social working environment were described as less stressful; however, the differences in the perception of stressfulness of these environments were minor. Socio-demographic determinants of the participants (age, marital status and education level) significantly affected the perception of stress at work. Significant differences in the perception of stressfulness of particular stress factors were observed among nurses with respect to psychological and somatic symptoms (such as headache, insomnia, fatigue, despair, lower back pain, mood swings etc.) and certain diseases (such as hypertension, myocardial infarction, stroke, diabetes mellitus etc). In view of permanent escalation of professional stressors, creating a supportive working environment is essential for positive health outcomes, prevention of job-related diseases and better protection of already ill nurses.Cilj je ovoga rada bio identifi cirati i analizirati profesionalne stresore, procijeniti razinu stresa kod medicinskih sestara u jedinicama intenzivne njege te procijeniti korelaciju izmeÄu percepcije stresa i prisutnosti psiholoÅ”kih i somatskih simptoma ili bolesti kod medicinskih sestara. Istraživanje je provedeno u obliku studije presjeka u Jedinicama intenzivne njege u zdravstvenim centrima u Srbiji. Uzorak se sastojao od 1000 medicinskih sestara-tehniÄara. Za procjenu i analizu profesionalnih stresora koriÅ”ten je upitnik Expanded Nursing Stress Scale (ENSS), koji je pokazao validne metrijske karakteristike na naÅ”oj ispitanoj populaciji. Medicinske sestre u Jedinicama intenzivne njege ocijenile su situacije iz fiziÄkoga i psiholoÅ”koga radnog okruženja kao izrazito optereÄujuÄe, a situacije iz socijalnoga radnog okruženja kao manje optereÄujuÄe. Razlika u percepciji stresogenosti navedenih radnih okruženja nije bila statistiÄki znaÄajna. Sociodemografske determinante ispitanika (dob, braÄno stanje i stupanj obrazovanja) znaÄajno utjeÄu na percepciju stresa na radnom mjestu. UtvrÄena je statistiÄki znaÄajna razlika u opažanju stresogenosti pojedinih stresnih situacija na radnom mjestu izmeÄu medicinskih sestara u odnosu na postojanje psihosomatskih simptoma (kao Å”to su glavobolja, nesanica, umor, oÄaj, bol u leÄima, Äeste promjene raspoloženja) ili odreÄenih bolesti (kao Å”to su poviÅ”ena hipertenzija, infarkt miokarda, cerebrovaskularni inzult, Å”eÄerna bolest). Zbog sve izraženije prisutnosti profesionalnih stresora nužno je poduzeti odreÄene strateÅ”ke mjere kod medicinskih sestara u Jedinicama intenzivne njege. StrateÅ”ke mjere podrazumijevaju unaprjeÄenje psihosocijalne radne klime, Å”to bi unaprijedilo njihovo zdravlje i sprijeÄilo nastanak bolesti u svezi s radom, ali i omoguÄilo bolju zaÅ”titu veÄ oboljelim medicinskim sestrama
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