Continuing data analysis of the AS/E grazing incidence X-ray telescope experiment on the OSO-4 satellite

The work to correct and extend the calculation of the theoretical solar X-ray spectrum produced during earlier OSO-4 data analysis is reported along with the work to formulate models of active regions, and compare these models with the experimental values. An atlas of solar X-ray photographs is included, and solar X-ray observations are correlated with the solar wind

Folding of VemP into translation-arresting secondary structure is driven by the ribosome exit tunnel

The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact with the tunnel walls or small molecules such as antibiotics. These interactions can cause translational arrest with notable physiological consequences. Here, we studied the arrest caused by the regulatory peptide VemP, which is known to form alpha-helices inside the ribosome tunnel near the peptidyl transferase center under specific conditions. We used all-atom molecular dynamics simulations of the entire ribosome and circular dichroism spectroscopy to study the driving forces of helix formation and how VemP causes the translational arrest. To that aim, we compared VemP dynamics in the ribosome tunnel with its dynamics in solution. We show that the VemP peptide has a low helical propensity in water and that the propensity is higher in mixtures of water and trifluorethanol. We propose that helix formation within the ribosome is driven by the interactions of VemP with the tunnel and that a part of VemP acts as an anchor. This anchor might slow down VemP progression through the tunnel enabling alpha-helix formation, which causes the elongation arrest

A Contemporary View of Coronal Heating

Determining the heating mechanism (or mechanisms) that causes the outer atmosphere of the Sun, and many other stars, to reach temperatures orders of magnitude higher than their surface temperatures has long been a key problem. For decades the problem has been known as the coronal heating problem, but it is now clear that `coronal heating' cannot be treated or explained in isolation and that the heating of the whole solar atmosphere must be studied as a highly coupled system. The magnetic field of the star is known to play a key role, but, despite significant advancements in solar telescopes, computing power and much greater understanding of theoretical mechanisms, the question of which mechanism or mechanisms are the dominant supplier of energy to the chromosphere and corona is still open. Following substantial recent progress, we consider the most likely contenders and discuss the key factors that have made, and still make, determining the actual (coronal) heating mechanism (or mechanisms) so difficult

High resolution studies of the solar X-ray corona from Aerobee rockets

The research in high resolution solar X-ray astronomy is reported. The payload for the Aerobee 150 launch vehicle, which included a 23 cm diameter mirror whose polished surface was a nickel-phosphorus alloy is discussed along with the high resolution measurements, by Flight 13.028 CS, of the temperature and density structure of the lower corona. Flight 13.029 CS is also discussed

The structure and dynamics of a bright point as seen with Hinode, SoHO and TRACE

Our aim is to determine the plasma properties of a coronal bright point and compare its magnetic topology extrapolated from magnetogram data with its appearance in X-ray images. We analyse spectroscopic data obtained with EIS/Hinode, Ca II H and G-band images from SOT/Hinode, UV images from TRACE, X-ray images from XRT/Hinode and high-resolution/high-cadence magnetogram data from MDI/SoHO. The BP comprises several coronal loops as seen in the X-ray images, while the chromospheric structure consists of tens of small bright points as seen in Ca II H. An excellent correlation exists between the Ca II BPs and increases in the magnetic field, implying that the Ca II H passband is a good indicator for the concentration of magnetic flux. Doppler velocities between 6 and 15 km/s are derived from the Fe XII and Fe XIII lines for the BP region, while for Fe XIV and Si VII they are in the range from -15 to +15 km/s. The coronal electron density is 3.7x10^9 cm^-3. An excellent correlation is found between the positive magnetic flux and the X-ray light-curves. The remarkable agreement between the extrapolated magnetic field configuration and some of the loops composing the BP as seen in the X-ray images suggests that a large fraction of the magnetic field in the bright point is close to potential. The close correlation between the positive magnetic flux and the X-ray emission suggests that energy released by magnetic reconnection is stimulated by flux emergence or cancellation.Comment: 10 pages with 11 figures. Accepted in Astronomy and Astrophysic

Coronal Temperature Diagnostic Capability of the Hinode/X-Ray Telescope Based on Self-Consistent Calibration

The X-Ray Telescope (XRT) onboard the Hinode satellite is an X-ray imager that observes the solar corona with unprecedentedly high angular resolution (consistent with its 1" pixel size). XRT has nine X-ray analysis filters with different temperature responses. One of the most significant scientific features of this telescope is its capability of diagnosing coronal temperatures from less than 1 MK to more than 10 MK, which has never been accomplished before. To make full use of this capability, accurate calibration of the coronal temperature response of XRT is indispensable and is presented in this article. The effect of on-orbit contamination is also taken into account in the calibration. On the basis of our calibration results, we review the coronal-temperature-diagnostic capability of XRT

High antiplasmodial activity of novel plasmepsins I and II inhibitors

The aim of this study was to develop new antiplasmodial compounds acting through distinct mechanisms during both the liver and the blood stages of the parasite life cycle. Compounds were designed on the basis of the "double-drug" approach: primaquine, which has been linked to statine-based inhibitors of plasmepsins (PLMs), the plasmodial aspartic proteases involved in degradation of hemeoglobin. The compounds were tested in vitro for anti-PLM I/PLM II activities and against chloroquine-sensitive (D10) and chloroquine-resistant (W2) strains of P. falciparum. An antiplasmodial activity (IC50) as low as 0.1 M was obtained, an excellent improvement in comparison with inhibitors previously reported (IC50 = 2-20 M). The killing activity was equally directed against both P. falciparum strains and was correlated to lipophilicity (calculated as ALogP), for all compounds but one (9). All compounds inhibited PLM I and PLM II in the nanomolar range (Ki = 1-700 nM). The most promising compounds (2, 6, 10) were not cytotoxic against human fibroblasts at 100 M and were highly selective for PLMs vs human cathepsin

Investigating ChaMPlane X-ray sources in the Galactic Bulge with Magellan LDSS2 spectra

We have carried out optical and X-ray spectral analyses on a sample of 136 candidate optical counterparts of X-ray sources found in five Galactic-bulge fields included in our Chandra Multi-wavelength Plane Survey. We use a combination of optical spectral fitting and quantile X-ray analysis to obtain the hydrogen column density towards each object, and a three-dimensional dust model of the Galaxy to estimate the most probable distance in each case. We present the discovery of a population of stellar coronal emission sources, likely consisting of pre-main sequence, young main sequence and main sequence stars, as well as a component of active binaries of RS CVn or BY Dra type. We identify one candidate quiescent low-mass X-ray binary with a sub-giant companion; we note that this object may also be an RS CVn system. We report the discovery of three new X-ray detected cataclysmic variables (CVs) in the direction of the Galactic Center (at distances ~2kpc). This number is in excess of predictions made with a simple CV model based on a local CV space density of <~ 10^-5 pc^-3, and a scale height ~200pc. We discuss several possible reasons for this observed excess.Comment: 41 pages, 11 figures. Accepted for publication in Astrophysical Journal, September 10 editio

Automated Coronal Hole Detection using Local Intensity Thresholding Techniques

We identify coronal holes using a histogram-based intensity thresholding technique and compare their properties to fast solar wind streams at three different points in the heliosphere. The thresholding technique was tested on EUV and X-ray images obtained using instruments onboard STEREO, SOHO and Hinode. The full-disk images were transformed into Lambert equal-area projection maps and partitioned into a series of overlapping sub-images from which local histograms were extracted. The histograms were used to determine the threshold for the low intensity regions, which were then classified as coronal holes or filaments using magnetograms from the SOHO/MDI. For all three instruments, the local thresholding algorithm was found to successfully determine coronal hole boundaries in a consistent manner. Coronal hole properties extracted using the segmentation algorithm were then compared with in situ measurements of the solar wind at 1 AU from ACE and STEREO. Our results indicate that flux tubes rooted in coronal holes expand super-radially within 1 AU and that larger (smaller) coronal holes result in longer (shorter) duration high-speed solar wind streams