Periodization of Development of Ethnic Relations of Western Ukraine and Poland (1918–1939)

The article makes an attempt to investigate the peculiarities and determine the regularities of cooperation between the Ukrainian and Polish states during the time of the Second Rzeczpospolita, to recreate the overall picture of events and their subsequent influence on the relations between the two countries. Analysis of the concepts of activities of various representatives of the Polish government is presented, which helps to prove that Poland's constant struggle for spheres of influence in the International arena led to unpleasant consequences that claimed the lives of the representatives of many nations, including Ukrainians and Poles. At the same time, the struggle of the Polish national chauvinists and the Ukrainian patriotic forces did not allow Ukrainians to defend the sovereignty of its state, since the military-political situation in the region, the position of the Entente countries, as well as the ethnic relations of the region did not contribute to this. The attempt to normalize the Ukrainian-Polish relations in the Second Commonwealth did not bring the expected results because it was not seen by the government as a positive solution to the problem. Having negatively impacted the life of Ukrainians, these actions were remembered as the last wasted attempt to improve the situation on the eve of the Second World War. Ukrainians in such a difficult situation were forced to adjust to the requirements of time, and therefore quite often changed the vector of activity toward the cultural and social direction. The intellectuals were fighting for the right to teach in Ukrainian in schools, preserving traditions and gaining minor rights and privileges. The positions of the Polish government, in this case, remained unchanged, with the exception of the insignificant tolerant statements of its individual representatives. Consequently, Polish politics did not achieve the desired results

The Impact of Engineering Design Process in Teaching and Learning to Enhance Students' Science Problem-Solving Skills

This study aimed to determine the impact of the integration of engineering design process (asking, imagining, planning, creating and improving) in an electrical & magnetism module to improve problem-solving skills in physics among secondary school students in Aceh, Indonesia. The quasi-experimental study was carried out with 82 form three (age 15 years old) students of a secondary school in Aceh Besar, Indonesia. The first author had randomly chosen two classes as the experimental group and two other classes as the control group. Independent samples t-test analysis was conducted to determine the difference between the physics teaching and learning module which integrated the five steps of engineering design process and the existing commonly used science “Pudak” teaching and learning module. The results of the independent samples t-test analysis showed that the use of the physics teaching and learning module which integrated the five steps of engineering design process was more effective compared to the use of the existing “Pudak” module in increasing the students' skills in solving physics problems. The findings of the study suggest that the science learning approach is appropriate to be applied in the teaching and learning of science to enhance science problem-solving skills among secondary school students. In addition, it can be used as a guide for teachers on how to implement the integration of the five steps of engineering design process in science teaching and learning practices

Access to Care for VA Dialysis Patients During Superstorm Sandy.

Introduction: This study examines the use of dialysis services by end-stage renal disease (ESRD) patients following the Superstorm Sandy-related, months-long closure of the New York campus of the US Department of Veterans Affairs (VA) New York Harbor VA Healthcare System (NYHHS, Manhattan VAMC). Methods: Outpatient visits, dialysis care, emergency department visits, and hospitalizations at VA and non-VA facilities for 47 Manhattan VAMC ESRD patients were examined 12 months pre- and post-Sandy using VA administrative and clinical data. Results: The Brooklyn campus of NYHHS, which is within ten miles of Manhattan VAMC, experienced the largest increase in the number of dialysis encounters after the closure. Dialysis encounters for VA patients also increased at non-VA facilities, rising on average, to 106 per month. For the James J Peters Bronx VAMC, the number of total dialysis encounters for Manhattan VAMC patients fluctuated between 39 and 43 per month, dropping to less than 30 after the Manhattan VAMC dialysis unit reopened. Conclusion: Manhattan VAMC ESRD patients used nearby alternate VA sites and non-VA clinics for their care during the closure of the Manhattan VAMC dialysis unit. The VA electronic health records played an important role in ensuring continuity of care for patients who exclusively used VAMC facilities post-Sandy because patient information was immediately accessible at other VA facilities. The events related to Superstorm Sandy highlight the need for dialysis providers to have a comprehensive disaster plan, including nearby alternate care sites that can increase service capacity when a dialysis facility is closed because of a disaster

Potential ring of Dirac nodes in a new polymorph of Ca3_3P2_2

We report the crystal structure of a new polymorph of Ca$_3$P$_2$, and an analysis of its electronic structure. The crystal structure was determined through Rietveld refinements of powder synchrotron x-ray diffraction data. Ca$_3$P$_2$ is found to be a variant of the Mn$_5$Si$_3$ structure type, with a Ca ion deficiency compared to the ideal 5:3 stoichiometry to yield a charge-balanced compound. We also report the observation of a secondary phase, Ca$_5$P$_3$H, in which the Ca and P sites are fully occupied and the presence of interstitial hydride ions creates a closed-shell electron-precise compound. We show via electronic structure calculations of Ca$_3$P$_2$ that the compound is stabilized by a gap in the density of states compared to the hypothetical compound Ca$_5$P$_3$. Moreover, the calculated band structure of Ca$_3$P$_2$ indicates that it should be a three-dimensional Dirac semimetal with a highly unusual ring of Dirac nodes at the Fermi level. The Dirac states are protected against gap opening by a mirror plane in a manner analogous to graphene. The results suggest that further study of the electronic properties of Ca$_3$P$_2$ will be of interest

CCD photometry in the region of NGC 6994: the remains of an old open cluster

We present the results of BV(RI)KC CCD photometry down to V=21 mag in the region of NGC 6994. To our knowledge, no photometry has previously been reported for this object and we find evidences that it is a poor and sparse old open cluster, with a minimum angular diameter of 9 arcmin, i.e. larger than the 3 arcmin originally assigned to it. We obtain a color excess EB-V = 0.07 ± 0.02 mag by means of the BVIC technique. Based on the theoretical isochrones from VandenBerg (1985) that are in better agreement with our data, we estimate for this cluster a distance from the Sun of 620 pc (V0 - MV = 9 ± 0.25 mag) and an age lying within the range of 2 - 3 Gyr, adopting solar metallicity. Thus, the corresponding cluster's Galactocentric distance is 8.1 kpc and is placed at about 350 pc below the Galactic plane. According to these results, NGC 6994 belongs to the old open cluster population located in the outer disk and at large distances from the Galactic plane, and must have suffered significant individual dynamical evolution, resulting in mass segregation and evaporation of low mass stars.Facultad de Ciencias Astronómicas y GeofísicasInstituto de Astrofísica de La Plat

CCD photometry in the region of NGC 6994: the remains of an old open cluster

We present the results of BV(RI)KC CCD photometry down to V=21 mag in the region of NGC 6994. To our knowledge, no photometry has previously been reported for this object and we find evidences that it is a poor and sparse old open cluster, with a minimum angular diameter of 9 arcmin, i.e. larger than the 3 arcmin originally assigned to it. We obtain a color excess EB-V = 0.07 ± 0.02 mag by means of the BVIC technique. Based on the theoretical isochrones from VandenBerg (1985) that are in better agreement with our data, we estimate for this cluster a distance from the Sun of 620 pc (V0 - MV = 9 ± 0.25 mag) and an age lying within the range of 2 - 3 Gyr, adopting solar metallicity. Thus, the corresponding cluster's Galactocentric distance is 8.1 kpc and is placed at about 350 pc below the Galactic plane. According to these results, NGC 6994 belongs to the old open cluster population located in the outer disk and at large distances from the Galactic plane, and must have suffered significant individual dynamical evolution, resulting in mass segregation and evaporation of low mass stars.Facultad de Ciencias Astronómicas y GeofísicasInstituto de Astrofísica de La Plat

Targeting a Pre-mRNA Structure with Bipartite Antisense Molecules Modulates Tau Alternative Splicing

Approximately 15% of human genetic diseases are estimated to involve dysregulation of alternative pre-mRNA splicing. Antisense molecules designed to alter these and other splicing events typically target continuous linear sequences of the message. Here, we show that a structural feature in a pre-mRNA can be targeted by bipartite antisense molecules designed to hybridize with the discontinuous elements that flank the structure and thereby alter splicing. We targeted a hairpin structure at the boundary between exon 10 and intron 10 of the pre-mRNA of tau. Mutations in this region that are associated with certain forms of frontotemporal dementia, destabilize the hairpin to cause increased inclusion of exon 10. Via electrophoretic mobility shift and RNase protection assays, we demonstrate that bipartite antisense molecules designed to simultaneously interact with the available sequences that immediately flank the tau pre-mRNA hairpin do indeed bind to this structured region. Moreover, these agents inhibit exon 10 splicing and reverse the effect of destabilizing disease-causing mutations, in both in vitro splicing assays and cell culture. This general bipartite antisense strategy could be employed to modulate other splicing events that are regulated by RNA secondary structure