What’s past is prologue: history, current status and future prospects of library development in Bhutan

Purpose This paper aims to outline the history of libraries in Bhutan, to describe the current state of library development and to recommend priority areas for library enhancement. Design/methodology/approach The authors have worked extensively as library professionals in Bhutan and share factual details derived from their personal experience. They review the published literature, particularly the fieldwork of two scholars who studied Bhutan’s libraries and library workers. The authors use their own experience to interpret those findings and make suggestions for future development. Findings The paper briefly traces the evolution of print culture and the history of libraries, exploring monastic, school, college, public and national libraries. The paper examines government policies regarding education and libraries and discusses the acknowledgment of the value of libraries and the lack of actual support. Originality/value There is limited study of the history of reading culture or libraries in Bhutan. The authors document their first-hand experiences and efforts to implement systems for library resource sharing and professional development. The authors hope that this record will serve to illuminate past effort, to describe the unique information environment in Bhutan and to guide future decision-making. The authors recommend many future avenues for study, including reading habits, information-seeking behavior and attitudes toward libraries and librarians

Atmospheric nitrogen oxides (NO and NO2) at Dome C, East Antarctica, during the OPALE campaign

Mixing ratios of the atmospheric nitrogen oxides NO and NO2 were measured as part of the OPALE (Oxidant Production in Antarctic Lands & Export) campaign at Dome C, East Antarctica (75.1 degrees S, 123.3 degrees E, 3233 m), during December 2011 to January 2012. Profiles of NOx mixing ratios of the lower 100m of the atmosphere confirm that, in contrast to the South Pole, air chemistry at Dome C is strongly influenced by large diurnal cycles in solar irradiance and a sudden collapse of the atmospheric boundary layer in the early evening. Depth profiles of mixing ratios in firn air suggest that the upper snowpack at Dome C holds a significant reservoir of photolytically produced NO2 and is a sink of gas-phase ozone (O-3). First-time observations of bromine oxide (BrO) at Dome C show that mixing ratios of BrO near the ground are low, certainly less than 5 pptv, with higher levels in the free troposphere. Assuming steady state, observed mixing ratios of BrO and RO2 radicals are too low to explain the large NO2 : NO ratios found in ambient air, possibly indicating the existence of an unknown process contributing to the atmospheric chemistry of reactive nitrogen above the Antarctic Plateau. During 2011-2012, NOx mixing ratios and flux were larger than in 2009-2010, consistent with also larger surface O-3 mixing ratios resulting from increased net O-3 production. Large NOx mixing ratios at Dome C arise from a combination of continuous sunlight, shallow mixing height and significant NOx emissions by surface snow (F-NOx). During 23 December 2011-12 January 2012, median F-NOx was twice that during the same period in 20092010 due to significantly larger atmospheric turbulence and a slightly stronger snowpack source. A tripling of F-NOx in December 2011 was largely due to changes in snowpack source strength caused primarily by changes in NO3- concentrations in the snow skin layer, and only to a secondary order by decrease of total column O-3 and associated increase in NO3- photolysis rates. A source of uncertainty in model estimates of F-NOx is the quantum yield of NO3- photolysis in natural snow, which may change over time as the snow ages

HST observations of the cometary blue compact dwarf galaxy UGC 4483: a relatively young galaxy?

We present V and I photometry of the resolved stars in the cometary blue compact dwarf galaxy UGC 4483 using Hubble Space Telescope Wide Field Planetary Camera 2 (WFPC2) images. The resulting I vs. (V-I) color-magnitude diagram (CMD) reaches limiting magnitudes V = 27.5 mag and I = 26.5 mag for photometric errors less than 0.2 mag. It reveals not only a young stellar population of blue main-sequence stars and blue and red supergiants, but also an older evolved population of red giant and asymptotic giant branch stars. The measured magnitude I = 23.65 +/- 0.10 mag of the red giant branch tip results in a distance modulus (m-M) = 27.63 +/- 0.12, corresponding to a distance of 3.4 +/- 0.2 Mpc. The youngest stars are associated with the bright H II region at the northern tip of the galaxy. The population of older stars is found throughout the low-surface-brightness body of the galaxy and is considerably more spread out than the young stellar population, suggesting stellar diffusion. The most striking characteristics of the CMD of UGC 4483 are the very blue colors of the red giant stars and the high luminosity of the asymptotic giant branch stars. Both of these characteristics are consistent with either: 1) a very low metallicity ([Fe/H] = -2.4 like the most metal-deficient globular clusters) and an old age of 10 Gyr, or 2) a higher metallicity ([Fe/H] = -1.4 as derived from the ionized gas emission lines) and a relatively young age of the oldest stellar population in UGC 4483, not exceeding ~ 2 Gyr. Thus our data do not exclude the possibility that UGC 4483 is a relatively young galaxy having formed its first stars only ~ 2 Gyr ago.Comment: 37 pages, 15 PS figures, to appear in Ap

Poly(ADP-ribose) Polyremase-1 (PARP-1) Inhibition: A Promising Therapeutic Strategy for ETS-Expressing Tumours.

ETS transcription factors are a highly conserved family of proteins involved in the progression of many cancers, such as breast and prostate carcinomas, Ewing's sarcoma, and leukaemias. This significant involvement can be explained by their roles at all stages of carcinogenesis progression. Generally, their expression in tumours is associated with a poor prognosis and an aggressive phenotype. Until now, no efficient therapeutic strategy had emerged to specifically target ETS-expressing tumours. Nevertheless, there is evidence that pharmacological inhibition of poly(ADP-ribose) polymerase-1 (PARP-1), a key DNA repair enzyme, specifically sensitises ETS-expressing cancer cells to DNA damage and limits tumour progression by leading some of the cancer cells to death. These effects result from a strong interplay between ETS transcription factors and the PARP-1 enzyme. This review summarises the existing knowledge of this molecular interaction and discusses the promising therapeutic applications