ИСПОЛЬЗОВАНИЕ ИНГИБИТОРА ЦИКЛИН-ЗАВИСИМЫХ КИНАЗ 4/6 (ПАЛБОЦИКЛИБ) В ТЕРАПИИ ГОРМОН-ЗАВИСИМОГО МЕТАСТАТИЧЕСКОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ. АНАЛИЗ ЗАТРАТЫ–ПОСЛЕДСТВИЯ.

A new generation of aromatase inhibitors and target therapy directed at cycline-dependent kinases 4 and 6 gives a new opportunity to treat metastatic breast cancer. However, the cost of innovative therapy remains high. We present results of the cost-consequence analysis of combination therapy with fulvestrant and palbociclib compared to fulvestrant monotherapy or combination of exemestan and everolimus as a second-line therapy for metastatic breast cancer. It was shown that the combination therapy involving palbociclib increased the length of quality-adjusted life by 191 days and overall survival by almost a year. The use of palbociclib increased the length of quality-adjusted life by 0.06 QALY compared to the combination arm consisting of everolimus. The cumulative 10 year cost per patient was equal to 5.3 million rubles for combination therapy with palbociclib and 3.5 million rubles for combination therapy with everolimus.Появление нового поколения ингибиторов ароматазы, а также таргетной терапии, направленной на циклин-зависимые киназы 4/6, предоставляет онкологам, лечащим пациенток с метастатическим раком молочной железы, новые возможности. Однако стоимость инновационной терапии высока. В представленной работе приведен анализ «затраты–последствия» при применении комбинированной терапии второй линии фулвестрантом и палбоциклибом в сравнении с монотерапией фулвестрантом или комбинированной терапией эверолимусом и эксеместаном, применяемых в лечении метастатического рака молочной железы. Установлено, что комбинированная терапия, включающая палбоциклиб, позволяет увеличить продолжительность качественной жизни на 191 день, а общую продолжительность – почти на год. По сравнению с комбинированной терапией, включающей эверолимус, применение палбоциклиба приводило к увеличению продолжительности качественной жизни на 0,06 QALY. При этом комбинированная терапия с палбоциклибом была ассоциирована с расходами на уровне 5,3 млн рублей за 10 лет, а эверолимусом на фоне меньшей средней продолжительности жизни пациента – 3,5 млн рублей

The Marshall Space Flight Center Development of Mirror Modules for the ART-XC Instrument aboard the Spectrum-Roentgen-Gamma Mission

The Marshall Space Flight Center (MSFC) is developing x-ray mirror modules for the ART-XC instrument on board the Spectrum-Roentgen Gamma Mission under a Reimbursable Agreement between NASA and the Russian Space Research Institute (IKI.) ART-XC will consist of seven co-aligned x-ray mirror modules with seven corresponding CdTe focal plane detectors. Currently, four of the modules are being fabricated by the Marshall Space Flight Center (MSFC.) Each MSFC module consist of 28 nested Ni/Co thin shells giving an effective area of 65 sq cm at 8 keV, response out to 30 keV, and an angular resolution of 45 arcsec or better HPD. Delivery of these modules to the IKI is scheduled for summer 2013. We present a status of the ART x-ray modules development at the MSFC

Aperiodic optical variability of intermediate polars - cataclysmic variables with truncated accretion disks

We study the power spectra of the variability of seven intermediate polars containing magnetized asynchronous accreting white dwarfs, XSS J00564+4548,IGR J00234+6141, DO Dra, V1223 Sgr, IGR J15094-6649, IGR J16500-3307 and IGR J17195-4100, in the optical band and demonstrate that their variability can be well described by a model based on fluctuations propagating in a truncated accretion disk. The power spectra have breaks at Fourier frequencies, which we associate with the Keplerian frequency of the disk at the boundary of the white dwarfs' magnetospheres. We propose that the properties of the optical power spectra can be used to deduce the geometry of the inner parts of the accretion disk, in particular: 1) truncation radii of the magnetically disrupted accretion disks in intermediate polars, 2) the truncation radii of the accretion disk in quiescent states of dwarf novaeComment: Accepted for publication in A&

ART-XC: A Medium-energy X-ray Telescope System for the Spectrum-R-Gamma Mission

The ART-XC instrument is an X-ray grazing-incidence telescope system in an ABRIXAS-type optical configuration optimized for the survey observational mode of the Spectrum-RG astrophysical mission which is scheduled to be launched in 2011. ART-XC has two units, each equipped with four identical X-ray multi-shell mirror modules. The optical axes of the individual mirror modules are not parallel but are separated by several degrees to permit the four modules to share a single CCD focal plane detector, 1/4 of the area each. The 450-micron-thick pnCCD (similar to the adjacent eROSITA telescope detector) will allow detection of X-ray photons up to 15 keV. The field of view of the individual mirror module is about 18 x 18 arcminutes(exp 2) and the sensitivity of the ART-XC system for 4 years of survey will be better than 10(exp -12) erg s(exp -1) cm(exp -2) over the 4-12 keV energy band. This will allow the ART-XC instrument to discover several thousand new AGNs

Development of Mirror Modules for the ART-XC Instrument

The Marshall Space Flight Center (MSFC) is developing x-ray mirror modules for the ART -XC instrument on board the Spectrum-Roentgen-Gamma Mission under a Reimbursable Agreement between NASA and the Russian Space Research Institute (IKI.) ART-XC will consist of seven co-aligned x-ray mirror modules with seven corresponding CdTe focal plane detectors. Currently, four of the modules are being fabricated by the Marshall Space Flight Center (MSFC.) Each MSFC module provides an effective area of 65 cm2 at 8 keV, response out to 30 keV, and an angular resolution of 45 arcsec or better HPD. We will present a status of the ART x-ray module development at MSFC

Two Years of Observations of the X-ray Pulsar SMC X-1 with the ART-P Telescope onboard the Granat Observatory

We present the observations of the pulsar SMC X-1 with the ART-P telescope onboard the Granat observatory. We investigate the variability of the flux from the source on time scales of several tens of days. The intensity variation of the pulsar are shown to be consistent with the presence of a periodicity in the system with a characteristic time scale of $\sim61$ days. The precession of an inclined accretion disk, as indirectly confirmed by the absence of low-state pulsations, may be responsible for the observed variability. The spectrum of the source is well described by a power-law energy dependence of the photon flux density with a slope of $\sim1.5$ and an exponential cutoff at energies above $\sim14-18$ keV. We estimated the inclinations between the planes of the orbit and the accretion disk and the magnetic field of the neutron star.Comment: 16 pages, 5 figure

Preliminary results of the alignment and Hartmann tests of the AZT-22 telescope

The AZT-22 telescope installed in Turkey (Antalia) was aligned and tested on stars by the Hartmann method. The rms normal deviation of an equivalent optical system is 0.040 ± 0.016 μm. The circle of confusion is 0.40 ± 0.04 arcsec in diameter at a 50% energy level. © 2001 MAIK "Nauka/Interperiodica"

The Marshall Space Flight Center Development of Mirror Modules for the ART-XC Ins1rument Aboard the Spectrum-Roentgen-Gamma Mission

The Spectrum-Rontgen-Gamma (SRG) mission is a Russian-German X-ray astrophysical observatory that carries two co-aligned and complementary X-ray telescope systems. The primary instrument is the German-led extended ROentgen Survey with an Imaging Telescope Array (eROSITA), a 7-module X-ray telescope system that covers the energy range from 0.2-12 keV. The complementary instrument is the Russian-led Astronomical Roentgen Telescope -- X-ray Concentrator (ART-XC or ART), a 7-module X-ray telescope system that provides higher energy coverage, up to 30 keV (with limited sensitivity above 12 keV)

On the Change of the Inner Boundary of an Optically Thick Accretion Disk around White Dwarfs Using the Dwarf Nova SS Cyg as an Example

We present the results of our studies of the aperiodic optical flux variability for SS Cyg, an accreting binary systemwith a white dwarf. The main set of observational data presented here was obtained with the ANDOR/iXon DU-888 photometer mounted on the RTT-150 telescope, which allowed a record(for CCD photometers) time resolution up to 8 ms to be achieved. The power spectra of the source's flux variability have revealed that the aperiodic variability contains information about the inner boundary of the optically thick flow in the binary system. We show that the inner boundary of the optically thick accretion disk comes close to the white dwarf surface at the maximum of the source's bolometric light curve, i.e., at the peak of the instantaneous accretion rate onto the white dwarf, while the optically thick accretion disk is truncated at distances 8.5e9 cm ~10 R_{WD} in the low state. We suggest that the location of the inner boundary of the accretion disk in the binary can be traced by studying the parameters of the power spectra for accreting white dwarfs. In particular, this allows the mass of the accreting object to be estimated.Comment: 9 pages, 7 figures, Published in Astronomy Letter