Time to think beyond sickle cell screening and haemoglobin electrophoresis: a case report and review of literature of sickle cell D-Punjab falsely labelled as sickle cell SS from central India

Sickle cell haemoglobin D disease (D-Punjab) is a rare variant of sickle cell disease (SCD) reported from central India. Exact incidence of pulmonary thrombosis in patients with HbSD is unknown. Pulmonary thrombosis is known complication of SCD but rare in case of HbSD pattern. We reported a case of 34-year-old male patient with HbSD (D-Punjab) with acute chest syndrome (ACS). CT pulmonary angiogram revealed near complete thrombosis of right middle lobe segmental and subsegmental branches with pulmonary infarct. Our patient responded to anticoagulant therapy. This case report is a reminder that HPLC should be done in all patients with sickle cell disease along with solubility test and hemoglobin electrophoresis to detect exact incidence of hemoglobin D disease in central India

Excitonic AND Logic Gates on DNA Brick Nanobreadboards

A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems

DNA-Controlled Excitonic Switches

Fluorescence resonance energy transfer (FRET) is a promising means of enabling information processing in nanoscale devices, but dynamic control over exciton pathways is required. Here, we demonstrate the operation of two complementary switches consisting of diffusive FRET transmission lines in which exciton flow is controlled by DNA. Repeatable switching is accomplished by the removal or addition of fluorophores through toehold-mediated strand invasion. In principle, these switches can be networked to implement any Boolean function

Resource Modelling: The Missing Piece of the HTA Jigsaw?

Within health technology assessment (HTA), cost-effectiveness analysis and budget impact analyses have been broadly accepted as important components of decision making. However, whilst they address efficiency and affordability, the issue of implementation and feasibility has been largely ignored. HTA commonly takes place within a deliberative framework that captures issues of implementation and feasibility in a qualitative manner. We argue that only through a formal quantitative assessment of resource constraints can these issues be fully addressed. This paper argues the need for resource modelling to be considered explicitly in HTA. First, economic evaluation and budget impact models are described along with their limitations in evaluating feasibility. Next, resource modelling is defined and its usefulness is described along with examples of resource modelling from the literature. Then, the important issues that need to be considered when undertaking resource modelling are described before setting out recommendations for the use of resource modelling in HTA

Controlled environments: an urban research agenda on microclimatic enclosure

Controlled environments create specialist forms of microclimatic enclosure that are explicitly designed to transcend the emerging limitations and increasing turbulence in existing modes of urban climatic conditions. Across different urban contexts, anthropogenic change is creating urban conditions that are too hot, cold, humid, wet, windy etc. to support the continued and reliable environments that are suitable for the reproduction of food, ecologies and human life. In response, there are emerging forms of experimentation with new logics of microclimatic governance that seek to enclose environments within membranes and develop artificially created internal ecologies that are precisely customized to meet the needs of the plant, animal or human occupants of these new forms of enclosure. While recognizing that enclosure has a long history in urbanism, design and architecture, we ask in this paper if a new logic of microclimatic governance is emerging in specific response to the ecological changes of the Anthropocene. The paper sets out a research agenda to investigate whether the ability of cities, states and corporates to design and construct internalized environments is now a strategic capacity that is critical to developing the knowledge, practices and technologies to reconfigure new forms of urban climatic governance that address the problems of climate change and ensure urban reproduction under conditions of turbulence

Structural and magnetic properties of Mn_1+xSi_xFe_1-xCr_1-xO₄ system

545-549The structural and magnetic properties of mixed spinel system Mn1+xSixFe1-xCr1-xO4 (x = 0.0, 0.1,0.2,0.3,0.4,0.5) have been investigated by X-ray diffraction and magnetization studies. X-ray intensity calculations indicate that Si4+ ions occupy only tetrahedral (A) sites replacing Fe3+ ions and Mn3+ ions replace Fe3+ ions from (B) site. The variation of saturation magnetic moment per formula unit measured at 300 K with the Si4+ content is explained on the basis of Neel’s collinear spin ordering model

Gas-phase oxidant-free oxidation of cyclohexanol overV₂O₅-MoO₃-M₂O (M = Na, K, Cs) catalysts

43-49Oxidant-free oxidation (dehydrogenation) of cyclohexanol is carried out in a down-flow integral laboratory scale reactor using different alkali doped catalysts. The effect of reaction temperature, contact time (W/F) and doping of alkali metals is studied to check its effect on nature of prominent products of the reaction (cyclohexanone and cyclohexene). At lower temperature the cyclohexanone prevails whereas at higher temperature cyclohexene is observed in prominence. Acid-modified catalysts (with boron and phosphorous) facilitated cyclohexene selectivity whereas alkali modified catalysts facilitated cyclohexanone selectivity. Calcination of sodium modified catalyst at different temperatures under static condition affect characteristic phase intensity and cyclohexanone selectivity. XRD investigation showed formation of different inorganic phases as the characteristic of dopant. Cesium modified catalyst showed better dehydrogenation activity