Implementation of Input Oriented Dynamic Voltage and Frequency Scaling for Multiplier on FPGA

This paper presents an Implementation of Dynamic voltage and frequency scaling according to input data. In the conventional method the power supply is fixed and independent on workload, so, voltage and area will be consumed unnecessary .Paper proposes the approach which focuses on making system dynamic for low power digital multiplier on reconfigurable device FPGA (Spartan III). For making system Dynamic input workload should be known and scanning is used to detect range of input so system can adjust voltage and frequency. Control signal generated from scanning which can dynamically change voltage and frequency for low power consumption according to input data

Performance of agriculture insurance schemes in India

Risk and Uncertainty,

Kinetics of Acid-catalysed Hydrolysis of Hexanohydroxamic Acid

1086-108

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF NOVEL PYRAZOLINE DERIVATIVES USING K NEAREST NEIGHBOUR MOLECULAR FIELD ANALYSIS METHOD

Objective: Malonyl CoA decarboxylase (MCD) enzyme plays important role in fatty acid and glucose oxidation. Inhibition of MCD might turn to a novel approach to treat ischemia. The main objective of this research article was to develop a novel pharmacophore for enhanced activity.Methods: Three-dimensional quantitative structure-activity relationships (3D-QSAR) was performed for pyrazoline derivatives as MCD inhibitors using VLife MDS 4.6 software. The QSAR model was developed using the stepwise 3D-QSAR kNN-MFA method.Results: The statistical results generated from kNN-MFA method indicated the significance and requirements for better MCD inhibitory activity. The information rendered by 3D-QSAR model may render to better understanding and designing of novel MCD inhibitors.Conclusion: 3D-QSAR is an important tool in understanding the structural requirements for the design of novel and potent MCD inhibitors. It can be employed to design new drug discovery

Comparative Study of Different Techniques in Speaker Recognition: Review

The speech is most basic and essential method of communication used by person.On the basis of individual information included in speech signals the speaker is recognized. Speaker recognition (SR) is useful to identify the person who is speaking. In recent years speaker recognition is used for security system. In this paper we have discussed the feature extraction techniques like Mel frequency cepstral coefficient (MFCC), Linear predictive coding (LPC), Dynamic time wrapping (DTW), and for classification Gaussian Mixture Models (GMM), Artificial neural network (ANN) Support vector machine (SVM)

Study on Forward Chaining and Reverse Chaining in Expert System

Expert systems are part of a general category of computer applications known as intelligence. Expert system are designed to solve complex problems. Expert Systems is a branch of AI designed to work within a particular domain. To solve expert-level problems, expert systems will need efficient access to a substantial domain knowledge base, and a reasoning mechanism to apply the knowledge to the problems they are given. Usually they will also need to be able to explain, to the users who rely on them, how they have reached their decisions. As an expert is a person who can solve a problem with the domain knowledge. This research paper introduces introduction, parts, application of expert system. and difference between forward chaining and Backward chaining and Exactly meaning of Chaining. ETL tools uses functionality to extract, transform and load data from one system into another system, but our expert advises they're not optimal for application-to-application communication. In artificial intelligence, an expert system is a computer system that emulates the decision-making ability of a human expert. The AI technology has become really advanced and its only matter of time when the machines will be able to learn almost anything. The machine learning algorithms are already very smart, however the Processing power has been a challenge in last decade .Now with the big data and distributed computing revolution this problem has become easy to solve. Many programmers and developers can start programming their own robots and other gadgets on their own. Artificial intelligence is a science and technology based on disciplines such as Computer Science, Biology, Psychology, Linguistics, Mathematics, and Engineering. A major thrust of AI is in the development of computer functions associated with human intelligence, such as reasoning, learning, and problem solving

A study of waist circumference, waist-hip ratio as markers of type 2 diabetes mellitus and their correlation with family history of diabetes

Background: Type 2 Diabetes, is almost an ‘epidemic’ in India. A lot has to be done to prevent or at least postpone its onset. Hence finding bio-markers is important to warn people and create awareness. In India people pay a lot of importance to Family History, and though a positive family history, may predict Diabetes, we wanted to study its correlation to other bio-markers.Methods: Waist circumference, Waist hip ratio was measured in 184 Type 2 Diabetes patients .And history of Diabetes in mother, father or both was recorded .Data tabulated and subjected to statistical analysis.Results: Of the total number (n=184) type 2 diabetes patients studied, males were 93, females 91. 74.2 % males and 83.5 % females had a waist circumference above cut-off (90 cms for males and 80cms for females). 35 males and 42 females had a family history of diabetes. Of these, Father was diabetic in 16 males and 16 females, while mother was diabetic in 19 males and 26 females.Conclusions: Waist circumference and waist hip ratio above cut-off values emerged as common positive findings in majority of type 2 diabetic patients. Family history, individually as Paternal or Maternal Diabetes did not show statistically significant correlation with waist circumference or Waist-hip ratio

DEVELOPMENT OF MUCOADHESIVE DELIVERY OF CHLORZOXAZONE POLYETHYLENE GLYCOL SOLID DISPERSION

ABSTRACTObjective: Chlorzoxazone (CLZ) is centrally acting skeletal muscle relaxant. It is insoluble in water, so employed for the formation of solid dispersions(SD) as a means to enhance the dissolution rate, and carrier selected was polyethylene glycol 6000 (PEG 6000).Methods: The SDs were prepared by different methods and characterized by in vitro drug release, drug content, fourier transform infraredspectroscopy (FTIR), differential scanning calorimetry, powder X-ray diffraction. All the SD showed dissolution improvement compare to pure drug.These techniques revealed distinct loss of drug crystallinity in the formulation accounting for enhancement in dissolution rate. The SD methodsshowing best in vitro drug release profile were selected in the further development of mucoadhesive buccal patches. A buccal patch has been developedusing two mucoadhesive polymers, i.e. hydroxyl propyl methyl cellulose K4M and carbopol 974. The patches were evaluated for the physicochemical,mechanical and drug release characteristics. The optimized patches showed good mechanical and physicochemical properties to withstand theenvironment of the oral cavity. The in-vitro permeation study showed that patches could deliver drug to the oral mucosa for a period of 8 hrs.Results: The results indicate that suitable bioadhesive buccal patches with good permeability could be prepared. The batches FH4 and FC4 showed81.95% and 79.97% permeated through goat mucosa membrane in 8 hrs. The physicochemical interactions were investigated by FTIR, showed noany evidence of interactions and were present in an unchanged state. The stability study for SD and buccal patch carried out revealed that were stablefor a period of 3-month.Conclusion: Phase-solubility studies indicate significantly increase in solubility. The optimized buccal patches showed good mechanical andphysicochemical properties to withstand environment of the oral cavity.Keywords: Solid dispersions, Chlorzoxazone, Dissolution studies, Buccal patch, In vitro permeation studies

A comparative study between dynamic hip screw and proximal femoral locking plate in the management of unstable pertrochanteric fracture femur

Background: Pertrochanteric fracture represent perhaps the most important public health problem facing the orthopedic surgeon today. The purpose of the present study is to compare dynamic hip screw with proximal femoral locking plate (PFLP) in pertrochanteric fracture femur. Method: During the period from December 2019 to August 2021, 50 patients with pertrochanteric fracture femur who were admitted in the orthopaedics department were selected. The 25 patients treated with PFLP and 25 patients treated with dynamic hip screw according to the standardized protocol. Patients were followed up for the 1 year. Results: The mean operative time and average intraoperative blood loss was more in PFLP group when compared with DHS group it was statically significant.  PFLP group has marginally better functional than DHS group. There was no difference in the radiological outcome between two group.Conclusions: PFLP can be feasible alternative to treatment of complex comminuted pertrochanteric fractures. It can be use in old age patients with osteoporotic bone which provide stable fixation

Ultrasound promoted stereoselective synthesis of 2,3-dihydrobenzofuran appended chalcones at ambient temperature

In the present investigation, an ultrasound promoted the synthesis of a series of (E)-3-(2,3-dihydrobenzofuran 5-yl)-1-(aryl)prop-2-en-1-one derivatives from 2,3-dihydrobenzofuran-5-carbaldehyde and various aromatic ketones under clean conditions. The application of ultrasound irradiation in organic reactions is one of the incredible tools of green chemistry as reactions can be carried out rapidly under neat conditions. A library of a novel (E)-3-(2,3-dihydrobenzofuran-5-yl)-1-(aryl)prop-2-en-1-one chalcone derivatives were synthesized in good to excellent yield under ultrasonic irradiation. The structures of all synthesized chalcone derivatives synthesized in this study have been established by using FT-IR, 1HNMR, 13CNMR, and HRMS techniques. The stereochemistry around C=C in the chalcones was shown to be trans by 1H NMR(Jab= 15.5Hz). The benefits of the present synthesis include mild reaction conditions, high yield, purification by non-chromatographic strategy and short reaction times, demonstrating the significance of this protocol in terms of waste reduction and energy efficiency