118 research outputs found

    The Pagenumber of Genus g Graph is 0(g)

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    In 1979, Berhart and Kainen conjectured that graphs of fixed genus g greater than or equal to 1 have unbounded pagenumber. This proves that genus g graphs can be embedded in 0(g) pages, thus disproving the conjecture. An Omega(square root of g) lower bound is also derived. The first algorithm in the literature for embedding an arbitrary graph in a book with a non-trivial upper bound on the number of pages is presented. First, the algorithm computes the genus g of a graph using the algorithm of Filotti, Miller, Reif (1979), which is polynomial-time for fixed genus. Second, it applies an optimal-time algorithm for obtaining an 0(g)-page book embedding. We give separate book embedding algorithms for the cases of graphs embedded in orientable and nonorientable surfaces. An important aspect of the construction is a new decomposition algorithm, of independent interest, for a graph embedded on a surface. Book embedding has application in several areas, two of which are directly related to the results obtained: fault-tolerant VLSI and complexity theory

    Thermodynamics of protein folding: a random matrix formulation

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    The process of protein folding from an unfolded state to a biologically active, folded conformation is governed by many parameters e.g the sequence of amino acids, intermolecular interactions, the solvent, temperature and chaperon molecules. Our study, based on random matrix modeling of the interactions, shows however that the evolution of the statistical measures e.g Gibbs free energy, heat capacity, entropy is single parametric. The information can explain the selection of specific folding pathways from an infinite number of possible ways as well as other folding characteristics observed in computer simulation studies.Comment: 21 Pages, no figure

    Solving the 3D Ising Model with the Conformal Bootstrap

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    We study the constraints of crossing symmetry and unitarity in general 3D Conformal Field Theories. In doing so we derive new results for conformal blocks appearing in four-point functions of scalars and present an efficient method for their computation in arbitrary space-time dimension. Comparing the resulting bounds on operator dimensions and OPE coefficients in 3D to known results, we find that the 3D Ising model lies at a corner point on the boundary of the allowed parameter space. We also derive general upper bounds on the dimensions of higher spin operators, relevant in the context of theories with weakly broken higher spin symmetries.Comment: 32 pages, 11 figures; v2: refs added, small changes in Section 5.3, Fig. 7 replaced; v3: ref added, fits redone in Section 5.

    Quantum Commuting Circuits and Complexity of Ising Partition Functions

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    Instantaneous quantum polynomial-time (IQP) computation is a class of quantum computation consisting only of commuting two-qubit gates and is not universal in the sense of standard quantum computation. Nevertheless, it has been shown that if there is a classical algorithm that can simulate IQP efficiently, the polynomial hierarchy (PH) collapses at the third level, which is highly implausible. However, the origin of the classical intractability is still less understood. Here we establish a relationship between IQP and computational complexity of the partition functions of Ising models. We apply the established relationship in two opposite directions. One direction is to find subclasses of IQP that are classically efficiently simulatable in the strong sense, by using exact solvability of certain types of Ising models. Another direction is applying quantum computational complexity of IQP to investigate (im)possibility of efficient classical approximations of Ising models with imaginary coupling constants. Specifically, we show that there is no fully polynomial randomized approximation scheme (FPRAS) for Ising models with almost all imaginary coupling constants even on a planar graph of a bounded degree, unless the PH collapses at the third level. Furthermore, we also show a multiplicative approximation of such a class of Ising partition functions is at least as hard as a multiplicative approximation for the output distribution of an arbitrary quantum circuit.Comment: 36 pages, 5 figure

    Description of Generalized Continued Fractions by Finite Automata

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    A generalized continued fraction algorithm associates with every real number x a sequence of integers; x is rational iff the sequence is finite. For a fixed algorithm, call a sequence of integers valid if it is the result of that algorithm on some input x0. We show that, if the algorithm is sufficiently well-behaved, then the set of all valid sequences is accepted by a finite automaton. I. Introduction. It is well known that every real number x has a unique expansion as a simple continued fraction in the form

    Abstract Interpretation of Indexed Grammars.

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    Indexed grammars are a generalization of context-free grammars and recognize a proper subset of context-sensitive languages. The class of languages recognized by indexed grammars are called indexed languages and they correspond to the languages recognized by nested stack automata. For example indexed grammars can recognize the language {a^n b^n c^n | n > = 1} which is not context-free, but they cannot recognize {(ab^n)^n) | n >= 1} which is context-sensitive. Indexed grammars identify a set of languages that are more expressive than context-free languages, while having decidability results that lie in between the ones of context-free and context-sensitive languages. In this work we study indexed grammars in order to formalize the relation between indexed languages and the other classes of languages in the Chomsky hierarchy. To this end, we provide a fixpoint characterization of the languages recognized by an indexed grammar and we study possible ways to abstract, in the abstract interpretation sense, these languages and their grammars into context-free and regular languages

    Completeness of classical spin models and universal quantum computation

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    We study mappings between distinct classical spin systems that leave the partition function invariant. As recently shown in [Phys. Rev. Lett. 100, 110501 (2008)], the partition function of the 2D square lattice Ising model in the presence of an inhomogeneous magnetic field, can specialize to the partition function of any Ising system on an arbitrary graph. In this sense the 2D Ising model is said to be "complete". However, in order to obtain the above result, the coupling strengths on the 2D lattice must assume complex values, and thus do not allow for a physical interpretation. Here we show how a complete model with real -and, hence, "physical"- couplings can be obtained if the 3D Ising model is considered. We furthermore show how to map general q-state systems with possibly many-body interactions to the 2D Ising model with complex parameters, and give completeness results for these models with real parameters. We also demonstrate that the computational overhead in these constructions is in all relevant cases polynomial. These results are proved by invoking a recently found cross-connection between statistical mechanics and quantum information theory, where partition functions are expressed as quantum mechanical amplitudes. Within this framework, there exists a natural correspondence between many-body quantum states that allow universal quantum computation via local measurements only, and complete classical spin systems.Comment: 43 pages, 28 figure

    Petri Nets with Fuzzy Logic (PNFL): Reverse Engineering and Parametrization

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    Background: The recent DREAM4 blind assessment provided a particularly realistic and challenging setting for network reverse engineering methods. The in silico part of DREAM4 solicited the inference of cycle-rich gene regulatory networks from heterogeneous, noisy expression data including time courses as well as knockout, knockdown and multifactorial perturbations. Methodology and Principal Findings: We inferred and parametrized simulation models based on Petri Nets with Fuzzy Logic (PNFL). This completely automated approach correctly reconstructed networks with cycles as well as oscillating network motifs. PNFL was evaluated as the best performer on DREAM4 in silico networks of size 10 with an area under the precision-recall curve (AUPR) of 81%. Besides topology, we inferred a range of additional mechanistic details with good reliability, e.g. distinguishing activation from inhibition as well as dependent from independent regulation. Our models also performed well on new experimental conditions such as double knockout mutations that were not included in the provided datasets. Conclusions: The inference of biological networks substantially benefits from methods that are expressive enough to deal with diverse datasets in a unified way. At the same time, overly complex approaches could generate multiple different models that explain the data equally well. PNFL appears to strike the balance between expressive power and complexity. This also applies to the intuitive representation of PNFL models combining a straightforward graphical notation with colloquial fuzzy parameters

    Threshold-dominated regulation hides genetic variation in gene expression networks

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    <p>Abstract</p> <p>Background</p> <p>In dynamical models with feedback and sigmoidal response functions, some or all variables have thresholds around which they regulate themselves or other variables. A mathematical analysis has shown that when the dose-response functions approach binary or on/off responses, any variable with an equilibrium value close to one of its thresholds is very robust to parameter perturbations of a homeostatic state. We denote this threshold robustness. To check the empirical relevance of this phenomenon with response function steepnesses ranging from a near on/off response down to Michaelis-Menten conditions, we have performed a simulation study to investigate the degree of threshold robustness in models for a three-gene system with one downstream gene, using several logical input gates, but excluding models with positive feedback to avoid multistationarity. Varying parameter values representing functional genetic variation, we have analysed the coefficient of variation (<it>CV</it>) of the gene product concentrations in the stable state for the regulating genes in absolute terms and compared to the <it>CV </it>for the unregulating downstream gene. The sigmoidal or binary dose-response functions in these models can be considered as phenomenological models of the aggregated effects on protein or mRNA expression rates of all cellular reactions involved in gene expression.</p> <p>Results</p> <p>For all the models, threshold robustness increases with increasing response steepness. The <it>CV</it>s of the regulating genes are significantly smaller than for the unregulating gene, in particular for steep responses. The effect becomes less prominent as steepnesses approach Michaelis-Menten conditions. If the parameter perturbation shifts the equilibrium value too far away from threshold, the gene product is no longer an effective regulator and robustness is lost. Threshold robustness arises when a variable is an active regulator around its threshold, and this function is maintained by the feedback loop that the regulator necessarily takes part in and also is regulated by. In the present study all feedback loops are negative, and our results suggest that threshold robustness is maintained by negative feedback which necessarily exists in the homeostatic state.</p> <p>Conclusion</p> <p>Threshold robustness of a variable can be seen as its ability to maintain an active regulation around its threshold in a homeostatic state despite external perturbations. The feedback loop that the system necessarily possesses in this state, ensures that the robust variable is itself regulated and kept close to its threshold. Our results suggest that threshold regulation is a generic phenomenon in feedback-regulated networks with sigmoidal response functions, at least when there is no positive feedback. Threshold robustness in gene regulatory networks illustrates that hidden genetic variation can be explained by systemic properties of the genotype-phenotype map.</p
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