21,477 research outputs found

    Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex.

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    Repeated exposure to stressors is known to produce large-scale remodeling of neurons within the prefrontal cortex (PFC). Recent work suggests stress-related forms of structural plasticity can interact with aging to drive distinct patterns of pyramidal cell morphological changes. However, little is known about how other cellular components within PFC might be affected by these challenges. Here, we examined the effects of stress exposure and aging on medial prefrontal cortical glial subpopulations. Interestingly, we found no changes in glial morphology with stress exposure but a profound morphological change with aging. Furthermore, we found an upregulation of non-nuclear glucocorticoid receptors (GR) with aging, while nuclear levels remained largely unaffected. Both changes are selective for microglia, with no stress or aging effect found in astrocytes. Lastly, we show that the changes found within microglia inversely correlated with the density of dendritic spines on layer III pyramidal cells. These findings suggest microglia play a selective role in synaptic health within the aging brain

    Observation of Enhanced Beaming from Photonic Crystal Waveguides

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    We report on the experimental observation of the beaming effect in photonic crystals enhanced via surface modes. We experimentally map the spatial field distribution of energy emitted from a subwavelength photonic crystal waveguide into free-space, rendering with crisp clarity the diffractionless beaming of energy. Our experimental data agree well with our numerical studies of the beaming enhancement in photonic crystals with modulated surfaces. Without loss of generality, we study the beaming effect in a photonic crystal scaled to microwave frequencies and demonstrate the technological capacity to deliver long-range, wavelength-scaled beaming of energy.Comment: 4 pages, 6 figure

    Design improvement of a pump wear ring labyrinth seal

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    The investigation was successful in obtaining two improved designs for the impeller wear ring seal of the liquid hydrogen turbopump of interest. A finite difference computer code was extensively used in a parametric computational study in determining a cavity configuration with high flow resistance due to turbulence dissipation. These two designs, along with that currently used, were fabricated and tested. The improved designs were denoted Type O and Type S. The measurements showed that Type O and Type S given 67 and 30 percent reduction in leakage over the current design, respectively. It was found that the number of cavities, the step height and the presence of a small stator groove are quite important design features. Also, the tooth thickness is of some significance. Finally, the tooth height and an additional large cavity cut out from the stator (upstream of the step) are of negligible importance

    Evolving database systems : a persistent view

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    Submitted to POS7 This work was supported in St Andrews by EPSRC Grant GR/J67611 "Delivering the Benefits of Persistence"Orthogonal persistence ensures that information will exist for as long as it is useful, for which it must have the ability to evolve with the growing needs of the application systems that use it. This may involve evolution of the data, meta-data, programs and applications, as well as the users' perception of what the information models. The need for evolution has been well recognised in the traditional (data processing) database community and the cost of failing to evolve can be gauged by the resources being invested in interfacing with legacy systems. Zdonik has identified new classes of application, such as scientific, financial and hypermedia, that require new approaches to evolution. These applications are characterised by their need to store large amounts of data whose structure must evolve as it is discovered by the applications that use it. This requires that the data be mapped dynamically to an evolving schema. Here, we discuss the problems of evolution in these new classes of application within an orthogonally persistent environment and outline some approaches to these problems.Postprin

    Complex Line Bundles over Simplicial Complexes and their Applications

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    Discrete vector bundles are important in Physics and recently found remarkable applications in Computer Graphics. This article approaches discrete bundles from the viewpoint of Discrete Differential Geometry, including a complete classification of discrete vector bundles over finite simplicial complexes. In particular, we obtain a discrete analogue of a theorem of Andr\'e Weil on the classification of hermitian line bundles. Moreover, we associate to each discrete hermitian line bundle with curvature a unique piecewise-smooth hermitian line bundle of piecewise constant curvature. This is then used to define a discrete Dirichlet energy which generalizes the well-known cotangent Laplace operator to discrete hermitian line bundles over Euclidean simplicial manifolds of arbitrary dimension

    Resonance solutions of the nonlinear Schr\"odinger equation in an open double-well potential

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    The resonance states and the decay dynamics of the nonlinear Schr\"odinger (or Gross-Pitaevskii) equation are studied for a simple, however flexible model system, the double delta-shell potential. This model allows analytical solutions and provides insight into the influence of the nonlinearity on the decay dynamics. The bifurcation scenario of the resonance states is discussed, as well as their dynamical stability properties. A discrete approximation using a biorthogonal basis is suggested which allows an accurate description even for only two basis states in terms of a nonlinear, nonhermitian matrix problem.Comment: 21 pages, 14 figure

    Relaminarisation of Re_Ď„=100 channel flow with globally stabilising linear feedback control

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    The problems of nonlinearity and high dimension have so far prevented a complete solution of the control of turbulent flow. Addressing the problem of nonlinearity, we propose a flow control strategy which ensures that the energy of any perturbation to the target profile decays monotonically. The controller’s estimate of the flow state is similarly guaranteed to converge to the true value. We present a one-time off-line synthesis procedure, which generalises to accommodate more restrictive actuation and sensing arrangements, with conditions for existence for the controller given in this case. The control is tested in turbulent channel flow (Re_τ = 100) using full-domain sensing and actuation on the wall-normal velocity. Concentrated at the point of maximum inflection in the mean profile, the control directly counters the supply of turbulence energy arising from the interaction of the wall-normal perturbations with the flow shear. It is found that the control is only required for the larger-scale motions, specifically those above the scale of the mean streak spacing. Minimal control effort is required once laminar flow is achieved. The response of the near-wall flow is examined in detail, with particular emphasis on the pressure and wall-normal velocity fields, in the context of Landahl’s theory of sheared turbulence
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