Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation

Immunocytochemical methods were used to localize type II Ca2+/calmodulin-dependent protein kinase in the macaque primary visual cortex. Neurons that stain for the kinase include both pyramidal and nonpyramidal cells and they appear to form a subset of cortical neurons. They are densely packed in layers II and IVB, somewhat more sparse in layers III, IVCß, and VI, and nearly absent in layer V. In normal animals the distribution of kinase-positive cells within each layer is relatively uniform. However, in animals in which one eye is removed 7-14 days before sacrifice or sutured shut for 9 or 11 weeks, the cells in layer IVCß are divided into alternating lightly and darkly stained bands. Comparison of immunocytochemically stained sections with adjacent sections stained for the mitochondrial enzyme, cytochrome oxidase, reveals that the kinase staining increases in ocular dominance columns originally driven by the removed or closed eye. These findings suggest that either the concentration of type II Ca2+/calmodulin-dependent protein kinase or its accessibility to the antibody probe increases dramatically and selectively in neurons of macaque primary visual cortex that have been deprived of their normal visual input. This may indicate that changing levels of activity in cortical neurons can alter their regulatory machinery

Perwujudan Representational Meaning Kim Shin Kwan Kong Di Klenteng Hok an Kiong Surabaya

Hok An Kiong chinese temple is the Tri Dharma's place of worship in Surabaya city, East Java. The research was conducted at Kwan Kong god statue and interior elements contained in the temple's main altar hall. This interior hall was designed by Fujian (Southern China) culture style and has been constructed since 1821 that are rich of original Chinese cultural values and historical values. The process of analysis using the iconography method by van Leeuwen, the purpose of this method is to determine the meaning of Kwan Kong god statue with first layer. The main function of Kwan Kong god statue physicaly as the worship orientation for the temple's worshipers, but by iconography method shows the impact who manifested in some of the interior elements in the temple's main altar hall

Evaluasi dan Perancangan Model Bisnis pada PT X di Surabaya dengan Pendekatan Business Model Canvas

Banyaknya pembangunan gedung-gedung baru, jasa substitusi dan lesunya perekonomian menyebabkan bisnis persewaan kantor di Surabaya lesu. Penelitian ini dilakukan dengan menggunakan metode kualitatif dengan menggunakan metode case study melalui wawancara terhadap pihak internal Perusahaan x dan pihak eksternal. Teknik pengambilan sampel yaitu purposive sampling. Metode analisis yang digunakan adalah triangulasi sumber Aspek yang menjadi perhatian yaitu Sembilan elemen business model canvas, selanjutnya dilakukan analisis SWOT pada masing-masing elemen tersebut serta membahas blue ocean strategy untuk Perusahaan XHasil dari penelitian ini ialah susunan business model canvas baru yang dapat dikembangkan oleh Perusahaan

Evaluasi Customer Relationship Management pada Supermarket Hero di Jakarta Timur

The growing of many big retailer make Hero Supermarket must obtaining it\u27s existance in retail business. Therefore, Hero Supermarket must form CRM (Customer Relationship Management) in order to increase a new customer, increase profit and maintaining customer, and pay attention to valuable customer. Data analysis done by searching procentage from many questions and cartesius diagram. The conclusion, the highest suitable level there are 98,27% of quality product and the lowest is the price of merchandise, which is 45,35%. Some atribute are over the customers hope, that is good shopping place image, completeness, the comfortable and easyness in shopping, and safetyness. There are five most important atribut, that is the price, quality, completeness, the comfortable and easyness in shopping, and parking space. Those atribute will determine wether the customer of Hero Supermarket will be loyal or not

Principal Component Analysis of RR Lyrae light curves

In this paper, we analyze the structure of RRab star light curves using Principal Component Analysis. We find this is a very efficient way to describe many aspects of RRab light curve structure: in many cases, a Principal Component fit with 9 parameters can describe a RRab light curve including bumps whereas a 17 parameter Fourier fit is needed. As a consequence we show statistically why the amplitude is also a good summary of the structure of a RR Lyrae light curve. We also use our analysis to derive an empirical relation relating absolute magnitude to light curve structure. In comparing this formula to those derived from exactly the same dataset but using Fourier parameters, we find that the Principal Component Analysis approach has disticnt advantages. These advantages are, firstly, that the errors on the coefficients in such formulae are smaller, and secondly, that the correlation between Principal Components is significantly smaller than the correlation between Fourier amplitudes. These two factors lead to reduced formal errors, in some cases estimated to be a factor of 2, on the eventual fitted value of the absolute magnitude. This technique will prove very useful in the analysis of data from existing large scale survey projects concerning variable stars.Comment: 8 pages, 10 figures, revised version, accepted for publication to MNRA

Finite element analysis applied to redesign of submerged entry nozzles for steelmaking

The production of steel by continuous casting is facilitated by the use of refractory hollow-ware components. A critical component in this process is the submerged entry nozzle (SEN). The normal operating conditions of the SEN are arduous, involving large temperature gradients and exposure to mechanical forces arising from the flow of molten steel; experimental development of the components is challenging in so hazardous an environment. The effects of the thermal stress conditions in relation to a well-tried design were therefore simulated using a finite element analysis approach. It was concluded from analyses that failures of the type being experienced are caused by the large temperature gradient within the nozzle. The analyses pointed towards a supported shoulder area of the nozzle being most vulnerable to failure and practical in-service experience confirmed this. As a direct consequence of the investigation, design modifications, incorporating changes to both the internal geometry and to the nature of the intermediate support material, were implemented, thereby substantially reducing the stresses within the Al2O3/graphite ceramic liner. Industrial trials of this modified design established that the component reliability would be significantly improved and the design has now been implemented in series production

Perancangan Web Interface Institut Teknologi Sepuluh Nopember (ITS) Dengan Memperhatikan Aspek Usability

Informasi dalam sebuah website atau web diharapkan dapat sampaikan dan diterima oleh pencari informasi dengan mudah. Di dalam Dunia pendidikan, informasi yang ada di dalam web juga diharapkan mampu diterima oleh para penggunanya dengan tujuan media komunikasi online seperti website dapat membantu para pelajar menerima ilmu yang disampaikan melalui media online. Untuk Mengetahui seberapa mudahnya informasi itu ditangkap ditandai dengan seberapa mudah website itu digunakan (USAble). Untuk mengetahui seberapa mudah penggunaan suatu website digunakan analisa USAbility, banyak metode yang dapat digunakan untuk mengidentifikasi masalah USAbility terutama dari sisi interface web. Heuristic evaluation merupakan salah satu teknik dalam melakukan hal tersebut yang digunakan dalam penelitian ini guna menilai seberapa mudahnya website Institut Teknologi Sepuluh Nopember dalam menyampaikan informasi yang ada. Dalam penelitian ini digunakan juga Quality Function Deployment (QFD) untuk mengidentifikasi keinginan pengguna terhadap tampilan dari web IT