STANDARDIZATION AND PHYTOCHEMICAL SCREENING OF BOUGAINVILLEA GLABRA

Objective: The objective of the current study was to identify, authenticate and prevent the adulteration of the plant Bougainvillea glabra. The following physicochemical parameters such as standardization, extraction and preliminary phytochemical screening helped in correct identification of the plant Bougainvillea glabra.Methods: Standardization includes the estimation of physicochemical parameters such as loss on drying, determination of pH range, determination of total ash, determination of water soluble ash, determination of acid insoluble ash, determination of sulfated ash and determination of hot water and ethanol-extractable matter. Preliminary phytochemical screening and TLC studies for all the extracts like chloroform, ethyl acetate and methanol were carried out by standard methods.Results: Results of loss on drying and the total ash value were found to be 8.1+0.24 and 6.26±0.05 respectively. The result for water soluble ash was found to be 1.34+0.04. The results for acid insoluble ash and sulfated ash were found to be 1.35±0.03 and 1.10±0.07, respectively. The values for water soluble and ethanol soluble extractive parameters were found to be 23.45±1.13 and 12.32±0.41 respectively Preliminary phytochemical screening for all the extracts revealed the presence of alkaloids, flavonoids, terpenoids, -glycosides and steroids in Bougainvillea glabra. Major constituents like alkaloids, flavonoids, tannins and glycosides were present in methanol extract. Alkaloids and flavonoids were also found in chloroform extract. The thin layer chromatography analysis of Bougainvillea glabra chloroform extract showed the presence of steroids with Rf values of 0.66 and 0.34 in benzene: ethyl acetate (85:15), chloroform: methanol (8:2) solvent systems correspondingly. The TLC analysis of ethyl acetate extract showed the presence of flavonoids with Rf values of 0.66 and 0.75 in toluene: dioxin: acetic acid (78:14:5) chloroform: acetone: formic acid (64:12.3:3.2) solvent systems, correspondingly.Conclusion: The results of standardization parameters ensure quality and purity of the plant material Bougainvillea glabra. Phytochemical screening revealed the presence of various phytoconstituents like flavonoids, alkaloids and glycosides. TLC studies indicated the ash value, pH determination and solubility parameters. The data obtained from the present study provide useful data which will helpful in identification and doing research work in future

Pathya Apathya of Visha w.s.r. to Prayoga Samucchaya

Agadatantra deals with the study of poison and its treatment and is given utmost importance among the branches of Ayurveda owing to its need for emergency management. Pathya Apathya is very important in the management of Visha Roga to keep the Dhatus in normal state and will not let them vitiated more by the action of Visha Gunas. People are exposed to different toxins, bites and stings and it’s the need of hour to understand properly about the Pathya Apathya to be followed in such conditions. This articles highlights the relevance of Pathya and Apathya in Visha Chikitsa from the malayalam text Prayoga Samucchaya

Haematological and Biochemical Changes in Response to Stress Induced by the Administration of Amikacin Injection by Autoinjector in Animals

The drugs administered by autoinjectors, may act fast reducing the morbidity and mortality in critical and emergency situations. Amikacin drug cartridge was developed for the autoinjector as an antibacterial drug for critical situations and its tolerability was studied. Rats were given either 3 doses or 7 doses on consecutive days by the autoinjector (intraperitoneal, 63 mg/mL). Blood was withdrawn on the 4th day (3 doses) or the 8th day (7 doses), and haematological and biochemical parameters were studied. All the parameters studied were within the limits and did not show any significant difference when compared with the control. Rabbits were given 3 doses of two concentrations (intramuscular, 63 or 250 mg/mL) and on the 4th day blood was withdrawn for the haematological and biochemical estimations. 63 mg/mL cartridge did not show any significant change while 250 mg/mL cartridge showed significant change in the haematological and biochemical parameters. This study showed that intraperitoneal injection of amikacin by the autoinjector designed for intramuscular injection was well tolerated by the rats. In the rabbits, low dose (63 mg/mL) was tolerated while the higher dose, which is an adult human dose (250 mg/mL) showed significant changes.Defence Science Journal, 2014, 64(2), pp. 99-105. DOI: http://dx.doi.org/10.14429/dsj.64.503

Real-time Thermal Error Compensation Module for Intelligent Ultra Precision Turning Machine (iUPTM)

AbstractAccuracy & precision are 1he main requirements for ultra precision machine tools. Many factors affect 1he performance of 1he system 1hat in turns affect 1he product quality. Among all sources of errors, the thermo mechanical deformation errors are the main contributor for 1he overall geometrical errors. This paper mainly aims at establislunent of methodology to compensate thermal deformation errors in real-time for ultra precision machine tools. The real-time thermal error compensation module has been developed and integrated to intelligent Ultra Precision Turning machine. The module includes temperatures as inputs, neural network algorithm for computing the thermal deformations errors, ‘C’ programming for real-time calculations and integration with open architecture CNC controller. The module runs in silent mode which avoids human intervention for correction of thermal deformation errors

A MEASUREMENTS INSERTION WITH LARGE DATA

The essential challenge for several big data programs is always to search data volumes and take functional understanding for other hobbies. Focused by real-world programs controlling of massive Data were revealed to get demanding yet very compelling job. We make as browse the efficient theorem that differentiates popular features of big data rising, and signifies big human sources representation, in the idea of data mining. Recommended theorem recommends that important popular features of big data are large by heterogeneous and varied data sources self-directed with distributed furthermore to decentralized control, and complicated, developing in data associations featuring believe that big data necessitate a big intelligence to improve data for finest values. We submit big human sources depiction, in the idea of data mining which data-driven structure involves demand determined choice of information sources, mining furthermore to analysis, modelling of user interest, and contemplation on security

Temporal and spatial variations in TEC using simultaneous measurements from the Indian GPS network of receivers during the low solar activity period of 2004?2005

International audienceWith the recent increase in the satellite-based navigation applications, the ionospheric total electron content (TEC) and the L-band scintillation measurements have gained significant importance. In this paper we present the temporal and spatial variations in TEC derived from the simultaneous and continuous measurements made, for the first time, using the Indian GPS network of 18 receivers located from the equator to the northern crest of the equatorial ionization anomaly (EIA) region and beyond, covering a geomagnetic latitude range of 1° S to 24° N, using a 16-month period of data for the low sunspot activity (LSSA) years of March 2004 to June 2005. The diurnal variation in TEC at the EIA region shows its steep increase and reaches its maximum value between 13:00 and 16:00 LT, while at the equator the peak is broad and occurs around 16:00 LT. A short-lived day minimum occurs between 05:00 to 06:00 LT at all the stations from the equator to the EIA crest region. Beyond the crest region the day maximum values decrease with the increase in latitude, while the day minimum in TEC is flat during most of the nighttime hours, i.e. from 22:00 to 06:00 LT, a feature similar to that observed in the mid-latitudes. Further, the diurnal variation in TEC show a minimum to maximum variation of about 5 to 50 TEC units, respectively, at the equator and about 5 to 90 TEC units at the EIA crest region, which correspond to range delay variations of about 1 to 8 m at the equator to about 1 to 15 m at the crest region, at the GPS L1 frequency of 1.575 GHz. The day-to-day variability is also significant at all the stations, particularly during the daytime hours, with maximum variations at the EIA crest regions. Further, similar variations are also noticed in the corresponding equatorial electrojet (EEJ) strength, which is known to be one of the major contributors for the observed day-to-day variability in TEC. The seasonal variation in TEC maximizes during the equinox months followed by winter and is minimum during the summer months, a feature similar to that observed in the integrated equatorial electrojet (IEEJ) strength for the corresponding seasons. In the Indian sector, the EIA crest is found to occur in the latitude zone of 15° to 25° N geographic latitudes (5° to 15° N geomagnetic latitudes). The EIA also maximizes during equinoxes followed by winter and is not significant in the summer months in the LSSA period, 2004?2005. These studies also reveal that both the location of the EIA crest and its peak value in TEC are linearly related to the IEEJ strength and increase with the increase in IEEJ

On the validity of the ionospheric pierce point (IPP) altitude of 350 km in the Indian equatorial and low-latitude sector

The GPS data provides an effective way to estimate the total electron content (TEC) from the differential time delay of L1 and L2 transmissions from the GPS. The spacing of the constellation of GPS satellites in orbits are such that a minimum of four GPS satellites are observed at any given point in time from any location on the ground. Since these satellites are in different parts of the sky and the electron content in the ionosphere varies both spatially and temporally, the ionospheric pierce point (IPP) altitude or the assumed altitude of the centroid of mass of the ionosphere plays an important role in converting the vertical TEC from the measured slant TEC and vice versa. In this paper efforts are made to examine the validity of the IPP altitude of 350 km in the Indian zone comprising of the ever-changing and dynamic ionosphere from the equator to the ionization anomaly crest region and beyond, using the simultaneous ionosonde data from four different locations in India. From this data it is found that the peak electron density height (<i>h<sub>p</sub>F<sub>2</sub></i>) varies from about 275 to 575 km at the equatorial region, and varies marginally from 300 to 350 km at and beyond the anomaly crest regions. Determination of the effective altitude of the IPP employing the inverse method suggested by Birch et al. (2002) did not yield any consistent altitude in particular for low elevation angles, but varied from a few hundred to one thousand kilometers and beyond in the Indian region. However, the vertical TEC computed from the measured GPS slant TEC for different IPP altitudes ranging from 250 to 750 km in the Indian region has revealed that the TEC does not change significantly with the IPP altitude, as long as the elevation angle of the satellite is greater than 50 degrees. However, in the case of satellites with lower elevation angles (<50°), there is a significant departure in the TEC computed using different IPP altitudes from both methods. Therefore, the IPP altitude of 350 km may be taken as valid even in the Indian sector but only in the cases of satellite passes with elevation angles greater than 50°

Prediction of thermal and energy transport of MHD Sutterby hybrid nanofluid flow with activation energy using Group Method of Data Handling (GMDH)

The present research work pursues GMDH for predicting thermal and energy transport of 2-D radiative magnetohydrodynamic (MHD) flow of hybrid Sutterby nanofluid across a moving wedge with activation energy. An exclusive class of nanoparticles SWCNT-Fe(3)O(4 )and MWCNT-Fe3O4 are dispersed into the ethylene glycol as regular fluid. The hybrid nanofluid mathematical model has been written as a system of partial differential equations (PDEs), which are then converted into ordinary differential equations (ODEs) through similarity replacements. Numerical solutions are attained Runge-Kutta-Fehlberg's fourth fifth-order (RKF-45) scheme by adopting the shooting technique. The ranges of diverse sundry parameters used in our study are Hartree parameter 0.1 <= m <= 0.5, magnetic parameter 0.3 <= M <= 1, Deborah number 0.1 <= De <= 1, moving wedge parameter 0.3 <= gamma <= 0.9, Reynolds number 0 <= Re <= 2.5, solid volume fraction of Fe3O4 and CNTs0.005 <= phi(1) <= 0.1,0.005 <= phi(2) <= 0.06, Browanian motion 0.1 <= Nb <= 0.4, thermophoresis parameter 0.1 <= Nt <= 0.25, Eckeret number 0.05 <= Ec <= 1, radiation parameter 1 <= R-d <= 2.5, Lewis number 0.5 <= Le <= 1.5, chemical reaction rate 0.1 <= sigma <= 0.7, heat source parameter, 0 <= delta <= 1.5 and activation energy 1 <= E <= 4 which shows up during the speed, thermal, and focus for Fe3O4/C2H6O2 nanofluid and CNTs-Fe3O4/C2H6O2 hybrid nanofluid. Additionally, the friction coefficient (C-fx), rate of heat transport (H-tx), and rate of nanoparticle transport (Nt(x) are calculated using GMDH. The numerical results for the current analysis are illustrated via tables, graphs, and contour plots. The efficiency of the proposed GMDH models is assessed using statistical measures such as MSE, MAE, RMSE, R, Error mean and Error StD. The predicted values are very close to the numerical results, and the coefficient of determination R-2 of C-fx,N-tx, and H-tx are 1, 0.97836 and 0.9960, respectively, which shows the best settlement

Geomagnetic activity control on VHF scintillations over an Indian low latitude station, Waltair (17.7°N, 83.3°E, 20°N dip)

Using the data of amplitude scintillations recorded at 244 MHz from the geostationary satellite, FLEETSAT (73° E) at a low latitude station, Waltair (17.7°N, 83.3°E, 20°N dip), during the increasing sunspot activity period of 1997-2000, the effect of the geomagnetic storms on the occurrence of ionospheric scintillations has been studied. A total of 60 SC storms studied during this period, following the Aarons' criterion, reveals that the local time of onset of the recovery phase of the geomagnetic storms play an important role in the generation or inhibition of the ionospheric irregularities. Out of the 60 storms studied, nearly 60 to 70% satisfied the categories I, II and III of Aarons' criteria. However, in the remaining 30 to 40% of the cases, no consistent results were observed. Thus, there is a necessity for further investigation of the effect of geomagnetic storms on ionospheric irregularities, particularly with reference to the altitude variations of the F-layer (h'F) relating to the changes in the local electric fields