Parasitic plants--A CuRe for what ails thee

Parasitic plants cause dramatic changes in ecosystems and represent a serious risk to agriculture by attacking crops of high economic importance. A highly conserved part of plant immune systems is the recognition of microbe-associated molecular patterns (MAMPs) by plasma membrane-localized pattern recognition receptors (PRRs) that initiate an effective immune response upon activation (1). Whether parasitic plants are also sensed as foes by these receptors was until now unknown. On page 478 of this issue, Hegenauer et al. report the identification of a canonical PRR that is required for responsiveness to a MAMP-like molecule from the parasitic plant Cuscuta reflexa and protects plants against parasitic attack (2). This finding opens the possibility of biotechnological applications for sustainable crop protection against these devastating parasites

Cancer du sein, mécanismes de défense et psychose

International audienceSome severe diseases as cancer provoke into patients important defensive strategies. This work explores the specificity of defenses implemented in the case of two female psychotic patients suffering of breast cancer – a pranoiac and a schizophrenic – as well as the effetc produced on a hallucinatory and delusion constructions.Certaines maladies somatiques graves, comme le cancer, provoquent des stratégies défensives importantes chez les patients. Ce travail explore la spécificité des mécanismes de défense mis en oeuvre dans le cas de deux patientes psychotiques atteintes d'un cancer du sein - une paranoïaque et une schizophrène - ainsi que l'effet produit sur les constructions délirantes et hallucinatoires

L'utilisation du processus de clivage chez une patiente cas-limite: Réflexion diagnostique et psychopathologique

International audienceFrom a clinical case concerning an ambulatory pathological non-selfcare without associated clinical signs and with a notably good social and professional fitting, authors present a psychopathological discussion. They discuss differntial diagnosis between obsessional neurosis, psychosis and borderliner case.A partir d'un cas clinique concernant une incurie à domicile sans signes cliniques associés, et avec notamment une bonne adaptation socio-professionnelle, les auteurs développent une discussion psychopathologique. Après l'étude du diagnostic différentiel, entre névrose obsessionnelle, psychose et état-limite, les auteurs soutiennent l'utilisation de mécanismes de défense tels que le clivage massif, chez un sujet cas-limite

A review of aceclofenac: Analgesic and anti-inflammatory effects on musculoskeletal disorders

Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with antiinflammatory and analgesic properties. Although there are some differences in the authorized indications between countries, aceclofenac is mainly recommended for the treatment of inflammatory and painful processes, such as low back pain (LBP), scapulohumeral periarthritis, extraarticular rheumatism, odontalgia, and osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). The analgesic properties and tolerability profile of aceclofenac in musculoskeletal disorders are reviewed, focusing on relevant and recent studies. The efficacy and safety comparison of aceclofenac with other analgesics and anti-inflammatory agents in OA, AS, RA, and LBP is described. Relevant studies were identified following a literature search of PubMed using the terms “aceclofenac” and “clinical trials” published from 1 Jan 1992 to 1 Jan 2020. Aceclofenac is at least as effective as other NSAIDs in reducing pain and/or improving functional capacity in chronic pain conditions (OA, AS, RA, and LBP). It is generally well tolerated and appears to have a more favorable GI profile than other NSAIDs. Thus, current evidence indicates that aceclofenac is a useful option for the management of pain and inflammation across a wide range of painful conditions

K^0-\bar{K}^0 mixing in the Standard Model from Nf=2+1+1 Twisted Mass Lattice QCD

We present preliminary results at {\beta} = 1.95 (a = 0.077 fm) on the first unquenched N_f=2+1+1 lattice computation of the B_K parameter which controls the neutral kaon oscillations in the Standard Model. Using N_f=2+1+1 maximally twisted sea quarks and Osterwalder-Seiler valence quarks we achieve O(a) improvement and a continuum-like renormalization pattern for the four-fermion operator. Our results are extrapolated/interpolated to the physical light/strange quark mass but not yet to the continuum limit. The computation of the relevant renormalization constants is performed non perturbatively in the RI'-MOM scheme using dedicated simulations with N_f=4 degenerate sea quark flavours produced by the ETM collaboration. We get B_K^{RGI} (a = 0.077) = 0.747(18), which when compared to our previous unquenched N_f=2 determination and most of the existing results, suggests a rather weak B_K^{RGI} dependence on the number of dynamical flavours. We are at the moment analysing lattice data at two additional {\beta} values which will allow us to perform an extrapolation to the continuum limit.Comment: 7 pages, 8 figures, Proceedings of Lattice 2011, XXIX International Symposium on Lattice Field Theory, Squaw Valley, Lake Tahoe, Californi

K^0-\bar{K}^0 Mixing Beyond the SM from Nf=2 tmQCD

We present preliminary results on the of neutral kaon oscillations in extensions of the Standard Model. Using Nf=2 maximally twisted sea quarks and Osterwalder-Seiler valence quarks, we achieve both O(a)-improvement and continuum-like renormalization pattern for the relevant four-fermion operators. We perform simulations at three values of the lattice spacing and extrapolate/interpolate our results to the continuum limit and physical light/strange quark mass. The calculation of the renormalization constants of the complete operator basis is performed non- perturbatively in the RI-MOM scheme.Comment: 7 pages, 2 figures; presented at the XXVIII International Symposium on Lattice Field Theory Villasimius, Sardinia, Ital

Kaon oscillations in the Standard Model and Beyond using Nf=2 dynamical quarks

We compute non-perturbatively the B-parameters of the complete basis of four-fermion operators needed to study the Kaon oscillations in the SM and in its supersymmetric extension. We perform numerical simulations with two dynamical maximally twisted sea quarks at three values of the lattice spacing on configurations generated by the ETMC. Unwanted operator mixings and O(a) discretization effects are removed by discretizing the valence quarks with a suitable Osterwalder-Seiler variant of the Twisted Mass action. Operators are renormalized non-perturbatively in the RI/MOM scheme. Our preliminary result for BK(RGI) is 0.73(3)(3).Comment: 7 pages, 3 figures, 1 table, proceedings of the XXVII Int'l Symposyum on Lattice Field Theory (LAT2009), July 26-31 2009, Peking University, Beijing (China

Quark and Gluon Propagators in Covariant Gauges

We present data for the gluon and quark propagators computed in the standard lattice Landau's gauge and for three values of the covariant gauge-fixing parameter lambda=0,8,16. Our results are obtained using the SU(3) Wilson action in the quenched approximation at beta=6.0 and volume=16^3x32.Comment: Lattice2001(theorydevelop

Understanding chemical reactions within a generalized Hamilton-Jacobi framework

Reaction paths and classical and quantum trajectories are studied within a generalized Hamilton-Jacobi framework, which allows to put on equal footing topology and dynamics in chemical reactivity problems. In doing so, we show how high-dimensional problems could be dealt with by means of Caratheodory plots or how trajectory-based quantum-classical analyses reveal unexpected discrepancies. As a working model, we consider the reaction dynamics associated with a Mueller-Brown potential energy surface, where we focus on the relationship between reaction paths and trajectories as well as on reaction probability calculations from classical and quantum trajectories.Comment: 22 pages, 5 figures, 1 tabl