16,837 research outputs found
Hall of Mirrors Scattering from an Impurity in a Quantum Wire
This paper develops a scattering theory to examine how point impurities
affect transport through quantum wires. While some of our new results apply
specifically to hard-walled wires, others--for example, an effective optical
theorem for two-dimensional waveguides--are more general. We apply the method
of images to the hard-walled guide, explicitly showing how scattering from an
impurity affects the wire's conductance. We express the effective cross section
of a confined scatterer entirely in terms of the empty waveguide's Green's
function, suggesting a way in which to use semiclassical methods to understand
transport properties of smooth wires. In addition to predicting some new
phenomena, our approach provides a simple physical picture for previously
observed effects such as conductance dips and confinement-induced resonances.Comment: 19 pages, 8 figures. Accepted for publication in Physical Review B.
Minor additions to text, added reference
Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein
The serine/threonine kinases ROCK1 and ROCK2 are central mediators of actomyosin contractile force generation that act downstream of the RhoA small GTP-binding protein. As a result, they have key roles in regulating cell morphology and proliferation, and have been implicated in numerous pathological conditions and diseases including hypertension and cancer. Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (ROCK2:ER). This two-stage system of regulation allows for tissue-selective expression of the ROCK2:ER fusion protein, which then requires administration of estrogen analogues such as tamoxifen or 4-hydroxytamoxifen to elicit kinase activity. This conditional gain-of-function system was validated in multiple tissues by crossing with mice expressing CRE recombinase under the transcriptional control of cytokeratin14 (K14), murine mammary tumor virus (MMTV) or cytochrome P450 Cyp1A1 (Ah) promoters, driving appropriate expression in the epidermis, mammary or intestinal epithelia respectively. Given the interest in ROCK signaling in normal physiology and disease, this mouse line will facilitate research into the consequences of ROCK activation that could be used to complement conditional knockout models
WILLINGNESS-TO-PAY FOR VALUE ADDED BRED HEIFER CHARACTERISTICS
Livestock Production/Industries,
A System for Accessible Artificial Intelligence
While artificial intelligence (AI) has become widespread, many commercial AI
systems are not yet accessible to individual researchers nor the general public
due to the deep knowledge of the systems required to use them. We believe that
AI has matured to the point where it should be an accessible technology for
everyone. We present an ongoing project whose ultimate goal is to deliver an
open source, user-friendly AI system that is specialized for machine learning
analysis of complex data in the biomedical and health care domains. We discuss
how genetic programming can aid in this endeavor, and highlight specific
examples where genetic programming has automated machine learning analyses in
previous projects.Comment: 14 pages, 5 figures, submitted to Genetic Programming Theory and
Practice 2017 worksho
Domain Walls Motion and Resistivity in a Fully-Frustrated Josephson Array
It is identified numerically that the resistivity of a fully-frustrated
Josephson-junction array is due to motion of domain walls in vortex lattice
rather than to motion of single vortices
Moving Wigner Glasses and Smectics: Dynamics of Disordered Wigner Crystals
We examine the dynamics of driven classical Wigner solids interacting with
quenched disorder from charged impurities. For strong disorder, the initial
motion is plastic -- in the form of crossing winding channels. For increasing
drive, the disordered Wigner glass can reorder to a moving Wigner smectic --
with the electrons moving in non-crossing 1D channels. These different dynamic
phases can be related to the conduction noise and I(V) curves. For strong
disorder, we show criticality in the voltage onset just above depinning. We
also obtain the dynamic phase diagram for driven Wigner solids and prove that
there is a finite threshold for transverse sliding, recently found
experimentally.Comment: 4 pages, 4 postscript figure
Numerical methods for non-LTE line radiative transfer: Performance and convergence characteristics
Comparison is made between a number of independent computer programs for
radiative transfer in molecular rotational lines. The test models are
spherically symmetric circumstellar envelopes with a given density and
temperature profile. The first two test models have a simple power law density
distribution, constant temperature and a fictive 2-level molecule, while the
other two test models consist of an inside-out collapsing envelope observed in
rotational transitions of HCO+. For the 2-level molecule test problems all
codes agree well to within 0.2%, comparable to the accuracy of the individual
codes, for low optical depth and up to 2% for high optical depths (tau=4800).
The problem of the collapsing cloud in HCO+ has a larger spread in results,
ranging up to 12% for the J=4 population. The spread is largest at the radius
where the transition from collisional to radiative excitation occurs. The
resulting line profiles for the HCO+ J=4-3 transition agree to within 10%,
i.e., within the calibration accuracy of most current telescopes. The
comparison project and the results described in this paper provide a benchmark
for future code development, and give an indication of the typical accuracy of
present day calculations of molecular line transfer.Comment: Accepted for publication in A&
Superconducting Fluxon Pumps and Lenses
We study stochastic transport of fluxons in superconductors by alternating
current (AC) rectification. Our simulated system provides a fluxon pump,
"lens", or fluxon "rectifier" because the applied electrical AC is transformed
into a net DC motion of fluxons. Thermal fluctuations and the asymmetry of the
ratchet channel walls induce this "diode" effect, which can have important
applications in devices, like SQUID magnetometers, and for fluxon optics,
including convex and concave fluxon lenses. Certain features are unique to this
novel two-dimensional (2D) geometric pump, and different from the previously
studied 1D ratchets.Comment: Phys. Rev. Lett. 83, in press (1999); 4 pages, 5 .gif figures;
figures also available at http://www-personal.engin.umich.edu/~nori/ratche
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