uMED: Sensibilidade ao contexto na medicina ubíqua.

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KARAKTERISASlTEMPATPERJNDUKANAedesDANPOTENSIPENULARAN DEMAMBERDARAHDENGUE(DBD)DIKELURAHANPURBAYAN KECAMATANKOTAGEDE, YOGYAKARTA

Demam Berdarah Dengue (DBD) adalah penyakit yang disebabkan oleh virus darifamili Flaviviridae dan ditularkan melalui perantara nyamuk dari genus Aedes. Tiap tahunnya terjadi peningkatan kasus DBD di Indonesia bahkan cenderung menjadi Kejadian Luar Biasa (KLB) di beberapa daerah. Salah satu cara yang efektif untuk mengurangi angka kesakitan adalah dengan pengendalian vektor. Pada tahun 2009, tercatat terjadi beberapa kasus DBD di Kelurahan Purbayan, sehingga perlu dilakukan suatu penelitian yang bertujuan untuk mempelajari karakteristik tempat perindukan nyamuk Aedes dan potensi terjadinya penularan DBD. Penelitian ini dilakukan pada bulan Oktober-November 2009. Metode yang digunakan adalah metode jelajah dengan mengambil 50 titik sampling dalam radius 100 meter. Survei dilakukan dengan memeriksa setiap tempat yang dianggap potensial sebagai tempat perindukan, baik di dalam ataupun di luar rumah. Larva nyamuk dikoleksi dan diidentifikasi. Kuisioner disampaikan saat koleksi larva. Data yang diperoleh dianalisis secara deskriptif dan statistik, kemudian ditentukan nilai Container index (CI), Home index (HI) dan Angka Bebas lentik (ABl). Hasi/ penelitian menunjukkan bahwa di Kel.Purbayan didapati larva nyamuk Aedes aegypti (35,71%) dan Aedes albopictus (53,58%). Karakter tempat perindukan yang potensial berupa bak mandi semen (CI 10%), ember plastik (2,86%), padasan tanah liat (2,86%), bak WCsemen (0,71%), ban bekas (0,71%), tempat minum burung (0,71%), aquarium (0,71%), danpot bunga gantung (0,71%). Secara keseluruhan nilai HI sebesar 48%, nilai ABl mencapai 52% dengan kontainer positifjentik lebih banyak terdapat di luar rumah (64,29%}. Sehingga disimpulkan bahwa Kelurahan Purbayan sangat berpotensi terjadi penularan DBD denganjenis jentik yang mendominasi adalah Aedes albopictus

Hallervorden-Spatz Syndrome

Background: A 28-year-old man was referred to the neurology department of our hospital with difficulty of social interaction, impairment in carrying out daily life activities and muscle rigidity. He had a history of head trauma 3 years ago. Neurological examination revealed bradykinesia, hypophonic speech, resting and postural tremor, rigidity, spasticity, hyperreflexia and psychosis

Descoberta semântica de recursos na Ubicomp: um estudo de caso aplicado a casas de vegetação.

Na Computação Ubíqua (Ubicomp) os recursos que constituem os ambientes devem estar compartilhados para serem acessados de qualquer lugar e a qualquer momento. Este artigo apresenta o EXEHDA-SD (SemanticDiscovery), um mecanismo para descoberta de recursos, que agrega em sua arquitetura tecnologias para o processamento semantico de requisições por recursos. Com isso, busca-se aumentara expressividade na representação e consulta de recursos. Para avaliar as funcionalidades do mecanismo é apresentado um estudo de caso desenvolvido na Embrapa ClimaTemperado

High resolution ancient sedimentary DNA shows that alpine plant diversity is associated with human land use and climate change.

The European Alps are highly rich in species, but their future may be threatened by ongoing changes in human land use and climate. Here, we reconstructed vegetation, temperature, human impact and livestock over the past ~12,000 years from Lake Sulsseewli, based on sedimentary ancient plant and mammal DNA, pollen, spores, chironomids, and microcharcoal. We assembled a highly-complete local DNA reference library (PhyloAlps, 3923 plant taxa), and used this to obtain an exceptionally rich sedaDNA record of 366 plant taxa. Vegetation mainly responded to climate during the early Holocene, while human activity had an additional influence on vegetation from 6 ka onwards. Land-use shifted from episodic grazing during the Neolithic and Bronze Age to agropastoralism in the Middle Ages. Associated human deforestation allowed the coexistence of plant species typically found at different elevational belts, leading to levels of plant richness that characterise the current high diversity of this region. Our findings indicate a positive association between low intensity agropastoral activities and precipitation with the maintenance of the unique subalpine and alpine plant diversity of the European Alps

Microplasma-assisted electrochemical synthesis of Co3O4 nanoparticles in absolute ethanol for energy applications

The authors thank the Engineering and Physical Sciences Research Council (EPSRC) for funding (EP/K036769/1, EP/K022237/1, EP/M024938/1). The authors would also like to acknowledge the EU COST Action TD1208 for useful exchanges and discussions. CN would like to thank the support from Fundamental Research Funds for the Central Universities (XDJK2017B033) and Research Funding of Southwest University (SWU117019) and Natural Science Foundation of China (NSFC, 51702264; 41371275).Plasma at the gas/liquid interface can promote a complex mixture of reactions in solution and microplasma-assisted direct-current anodic oxidation is an efficient and green process in synthesising nanoscale materials for various applications. In this study, we demonstrated the direct synthesis of crystalline Co3O4 quantum dots, ca. 2-5 nm in size, by direct anodization of Co foil with charge balanced by the microplasma at the flowing-helium/pure-ethanol interface under ambient condition. The anodic oxidation of cobalt in ethanol was analysed after characterising the solution using nuclear magnetic resonance (NMR), light absorption, photoluminescence (PL), and the solid product using X-ray photoemission spectroscopy (XPS), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Using the microplasma with high voltage under ambient condition, ethanol was oxidised to acetate as the charge carrier and the size of Co3O4 quantum dots can be controlled by the limiting current. The quantum dots from this method are well dispersed in ethanol and a dense coating for light absorption and a rectified diode can be processed directly from the suspension. These results reveals that microplasma-assisted anodisation in ethanol is an efficient and green route capable of manufacturing quantum dots at low-temperature and avoiding the use of extraneous ionic salts in electrolyte.PostprintPeer reviewe

Absence of mutations in four genes encoding for congenital cataract and expressed in the human brain in Tunisian families with cataract and mental retardation

<p>Abstract</p> <p>Background</p> <p>To identify the genetic defect associated with autosomal recessive congenital cataract (ARCC), mental retardation (MR) and ARCC, MR and microcephaly present in most patients in four Tunisian consanguineous families.</p> <p>Methods</p> <p>We screened four genes implicated in congenital cataract by direct sequencing in two groups of patients; those affected by ARCC associated to MR and those who presented also microcephaly. Among its three genes <it>PAX6</it>, <it>PITX3 </it>and <it>HSF4 </it>are expressed in human brain and one gene <it>LIM2 </it>encodes for the protein MP20 that interact with the protein galectin-3 expressed in human brain and plays a crucial role in its development. All genes were screened by direct sequencing in two groups of patients; those affected by ARCC associated to MR and those who presented also microcephaly.</p> <p>Results</p> <p>We report no mutation in the four genes of congenital cataract and its flanking regions. Only variations that did not segregate with the studied phenotypes (ARCC associated to MR, ARCC associated with MR and microcephaly) are reported. We detected three intronic variations in <it>PAX6 </it>gene: IVS4 -274insG (intron 4), IVS12 -174G>A (intron12) in the four studied families and IVS4 -195G>A (intron 4) in two families. Two substitutions polymorphisms in <it>PITX3 </it>gene: c.439 C>T (exon 3) and c.930 C>A (exon4) in one family. One intronic variation in <it>HSF4 </it>gene: IVS7 +93C>T (intron 7) identified in one family. And three intronic substitutions in <it>LIM2 </it>gene identified in all four studied families: IVS2 -24A>G (intron 2), IVS4 +32C>T (intron 4) and c.*15A>C (3'-downstream sequence).</p> <p>Conclusion</p> <p>Although the role of the four studied genes: <it>PAX6</it>, <it>PITX3</it>, <it>HSF4 </it>and <it>LIM2 </it>in both ocular and central nervous system development, we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, MR and microcephaly.</p