Hematopoietic Stem Cell Transplantation in Primary Immunodeficiencies in Brazil-a Survey of the Working Group on Paediatric Transplantation of the Brazilian Society of Bone Marrow Transplantation

Inst Crianca HCFMUSP, Sao Paulo, BrazilHosp Israelita Albert Einstein, Sao Paulo, BrazilInst Oncol Pediat, Sao Paulo, BrazilHosp Clin Porto Alegre, Porto Alegre, RS, BrazilUniv Fed Parana, Bone Marrow Transplantat Unit, BR-80060000 Curitiba, Parana, BrazilCtr Oncol & Hematol, Jau, BrazilUSP Ribeirao Preto, Hosp Clin, Ribeirao Preto, BrazilUniv Fed Minas Gerais, Belo Horizonte, MG, BrazilUniv Fed Rio de Janeiro, Rio De Janeiro, BrazilCtr Nacl Transplate Medula Ossea CEMO, Inst Nacl Canc, Rio De Janeiro, BrazilUniv Fed Parana, Paediat Intens Care Unit, BR-80060000 Curitiba, Parana, BrazilNatl Inst Canc INCA, Rio De Janeiro, BrazilHosp Israelita Albert Einstein, Hematol & Bone Marrow Transplantat Dept, Sao Paulo, BrazilWeb of Scienc

Systems biocatalysis: An artificial metabolism for interconversion of functional groups

An in vitro artificial cycle interconverting chemical functional groups through a series of six enzyme-catalyzed reactions was set up. The addition of any of the substrates established a steady state in which concentrations of all the four components remained unchanged, and transformation of any component into another is possible by breaking the cycle omitting one (or more) of the enzymatic activities. We believe that this example of an artificial metabolism may constitute a novel approach toward the synthesis of useful products by modern applied biocatalysis. Such an in vitro strategy circumvents the presence of deviating/competing metabolic pathways as well as the issues related to enzymes inhibition or regulation as observed at the cellular level

VISCOELASTIC BEHAVIOR OF DENSE MICROEMULSIONS

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VISCOELASTIC BEHAVIOR OF DENSE MICROEMULSIONS

no abstrac

Differential Micrornas Expression Profile In Primary Glioblastomas Of Children And Adults, Pilocytic Astrocytomas And Non-neoplastic White Matter: Identification Of Pathways Involved In Tumorigenesis.

624S283S28

Nimodipine selectively stimulates \u3b2-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage

Several lines of evidence indicate that perturbed cellular Ca2+ homeostasis may play a prominent role in synaptic dysfunction and neuronal death in Alzheimer's disease (AD), suggesting a potential benefit of drugs capable to stabilize Ca2+ homeostasis. We here investigated the effects of a panel of L-type Ca2+ channel antagonists on the secretion of the amyloid beta-peptide (Abeta), which abnormally accumulates in the senile plaques of the brain of AD patients. We found that, in primary and immortalized neuronal cells in culture, nimodipine robustly stimulated secretion (up to about four-fold at 30 microM) of the highly amyloidogenic 42-residue isoform of Abeta (Abeta42), while leaving largely unaffected total Abeta secretion. An analogous effect was also observed in vivo, as the administration of a single dose of nimodipine (10 mg/kg i.p.) induced a significant rise of Abeta42 levels in plasma of Tg2576 mice. The effect of nimodipine was independent of blockage of L-type Ca2+ channels and capacitative calcium entry. Accordingly, nimodipine effect was largely Ca2+-independent, as neither depletion nor rise of extracellular Ca2+ abolished it. Hence, by showing that the effect of nimodipine on Abeta42 production is distinct from its ability to block Ca2+-influx pathways, we provide evidence for a previously uncharacterized effect of this long known molecule also used in clinical practice