ANN-based sub-surface monitoring technique exploiting electromagnetic features extracted by GPR signals

Abstract. In this work we consider the problem of determining the dielectric characteristics of sub-surface layers by means of GPR systems. In particular, a suitable electromagnetic feature (the RΓ parameter), strictly related to the geophysical parameters of the scenario, is first extracted from the GPR e.m. signal and then fed to an artificial neural network (ANN) in order to derive the dielectric permittivity of the sub-surface layer

Geometric classification of 4d N= 2 SCFTs

The classification of 4d N= 2 SCFTs boils down to the classification of conical special geometries with closed Reeb orbits (CSG). Under mild assumptions, one shows that the underlying complex space of a CSG is (birational to) an affine cone over a simply-connected \u211a-factorial log-Fano variety with Hodge numbers h p,q = \u3b4 p,q . With some plausible restrictions, this means that the Coulomb branch chiral ring [InlineMediaObject not available: see fulltext.] is a graded polynomial ring generated by global holomorphic functions u i of dimension \u394 i . The coarse-grained classification of the CSG consists in listing the (finitely many) dimension k-tuples \u394 1 , \u394 2 , ef , \u394 k which are realized as Coulomb branch dimensions of some rank-k CSG: this is the problem we address in this paper. Our sheaf-theoretical analysis leads to an Universal Dimension Formula for the possible \u394 1 , ef , \u394 k \u2019s. For Lagrangian SCFTs the Universal Formula reduces to the fundamental theorem of Springer Theory. The number N(k) of dimensions allowed in rank k is given by a certain sum of the Erd\uf6s-Bateman Number-Theoretic function (sequence A070243 in OEIS) so that for large kN(k)=2\u3b6(2)\u3b6(3)\u3b6(6)k2+o(k2). In the special case k = 2 our dimension formula reproduces a recent result by Argyres et al. Class Field Theory implies a subtlety: certain dimension k-tuples \u394 1 , ef , \u394 k are consistent only if supplemented by additional selection rules on the electro-magnetic charges, that is, for a SCFT with these Coulomb dimensions not all charges/fluxes consistent with Dirac quantization are permitted. Since the arguments tend to be abstract, we illustrate the various aspects with several concrete examples and perform a number of explicit checks. We include detailed tables of dimensions for the first few k\u2019s

Special arithmetic of flavor

We revisit the classification of rank-1 4d N= 2 QFTs in the spirit of Diophantine Geometry, viewing their special geometries as elliptic curves over the chiral ring (a Dedekind domain). The Kodaira-N\ue9ron model maps the space of non-trivial rank-1 special geometries to the well-known moduli of pairs (\u3b5, F 1e) where E is a relatively minimal, rational elliptic surface with section, and F 1e a fiber with additive reduction. Requiring enough Seiberg-Witten differentials yields a condition on (\u3b5, F 1e) equivalent to the \u201csafely irrelevant conjecture\u201d. The Mordell-Weil group of E (with the N\ue9ron-Tate pairing) contains a canonical root system arising from ( 121)-curves in special position in the N\ue9ron-Severi group. This canonical system is identified with the roots of the flavor group F: the allowed flavor groups are then read from the Oguiso-Shioda table of Mordell-Weil groups. Discrete gaugings correspond to base changes. Our results are consistent with previous work by Argyres et al

The autoinflammatory diseases.

Summary The monogenic autoinflammatory syndromes are conditions caused by mutations of genes coding for proteins that play a pivotal role in the regulation of the inflammatory response. Due to their genetic nature, most of these disorders have an early onset. Clinically they are characterised by recurrent flares of systemic inflammation presenting most of the time as sudden fever episodes associated with elevation of acute phase reactants and with a number of clinical manifestations such as rash, serositis, lymphadenopathy and arthritis. Symptom-free intervals are characterised by complete wellbeing, normal growth and complete normalisation of acute phase reactants. Familial Mediterranean fever (FMF), mevalonate-kinase deficiency (MKD) and tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) are the three monogenic disorders subsumed under the term periodic fevers, while a systemic inflammation dominated by a characteristic urticarial rash associated with a number of other clinical manifestations is typical of familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurological cutaneous and articular syndrome (CINCA). These diseases represent the clinical spectrum of different mutations of a gene named cold-induced autoinflammatory syndrome 1 (CIAS-1, or NLRP3) coding for a protein called cryopyrin. Hence these disorders are also known as cryopyrin-associated periodic syndromes (CAPS). Other conditions are characterised by typical granulomatous formations (granulomatous disorders). Blau's syndrome (familial juvenile systemic granulomatosis) presents with non-caseating granulomatous inflammation affecting the joint, skin, and uveal tract (the triad of arthritis, dermatitis and uveitis) and is associated with mutations of the NACHT domain of the gene CARD15 (or NOD2)

Type I interferonopathies in pediatric rheumatology.

Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a constitutive activation of this pathway that might present as atypical, severe, early onset rheumatic diseases. Skin vasculopathy with chilblains and livedo reticularis, interstitial lung disease, and panniculitis are common. Recent studies have implicated abnormal responses to nucleic acid stimuli or defective regulation of downstream effector molecules in disease pathogenesis. As observed for IL1-β and autoinflammatory diseases, knowledge of the defects responsible for type I interferonopathies will likely promote the development of targeted therapy

Intrasexual vibrational behavior of Philaenus spumarius in semi-field conditions

Insects that communicate by vibrational signals live in a complex interactive network of communication. Most studies on insect intrasexual behavior, based on plant-borne vibrational signals, have targeted few individuals. Despite their importance, behaviors that occur within groups were often overlooked. The study of multiple individuals, when insects occur in high density could simulate the environment in which they live and provide more reliable information on their behavior. In semi-field conditions, we investigated the intrasexual behavior of the meadow spittlebug, Philaenus spumarius. Vibrational signals exchanged among individuals of the same sex were recorded throughout their adult stage, from late spring to early autumn, and during the day, from the morning to the evening using a laser vibrometer. Males were less active than females throughout the season and their interactions were less frequent compared to females. Intrasexual interactions were characterized by signal overlapping in both unisex groups, in addition to signal alternating only in the case of males. In conclusion, the study of signaling behavior in intrasexual groups contributed to a better understanding of P. spumarius social behavior. We discuss the hypothesis of a possible competitive behavior between males and cooperative behavior between female

Interstitial lung disease in a newborn affected by mevalonic aciduria

Introduction: Mevalonic aciduria (MA) is the most severe phenotype of mevalonate-kinase deficiency (MKD), with a onset in early infancy and poor prognosis. MA diagnosis may be challenging in the neonatal period given its rarity and its unspecific symptoms that frequently recall those of other neonatal diseases. To our knowledge, interstial lung involvement has never been described as onset feature in a newborn with MKD. Objectives: We report the case of a newborn affected by MKD characterized by interstitial lung disease. Methods: The patient underwent laboratory and radiology evaluation as clinically indicated. Direct Sanger sequencing was used to screen the 10 exons of the MVK gene. Results: A female neonate born at term from consanguineous parents was referred to our hospital at 16 days of life (DOL) for mild hypotonia and persistent raised inflammatory markers despite antibiotic therapy. Infectious work-up was negative for both viral and bacterial infections. Chest x-ray revealed bilateral perihilar peribronchial thickening. Electroencephalography (EEG) reported moderate diffuse anomalies of background activity without major abnormalities. On DOL 20 the first episode of fever was recorded. Due to worsening tachypnea and persistent abnormal chest x-ray, a pulmonary CT scan was performed and showed diffuse ground-glass bilateral infiltrates consistent with alveolar-interstitial lung disease. On DOL 22 a palpable maculo-papular skin rash appeared on feet and hands, vanishing spontaneously 24 hours later. Bone marrow examination and levels of perforins, neuron-specific enolase and urinary catabolites of catecholamines were normal. A total body MRI was normal except for a mild cerebellar hypoplasia and the known interstitial lung disease. The patient kept presenting hypotonia, relapsing episodes of fever and skin rashes, developed anemia requiring blood transfusions and failure to thrive became evident. Type-I IFN signature was negative. A genetic test was requested, as well as quantification of urinary levels of mevalonic acid, which were markedly above the normal range. Direct Sanger sequencing allowed to detect a homozygous c.709A>T missense mutation in the exon 8 of the MVK gene, coding for a protein substitution p.T237S already classified as pathogenic in the INFEVERS database (http://fmf.igh.cnrs.fr/ISSAID/infevers/) and therefore consistent with the diagnosis of MKD. Both parents and her sister were found to be heterozygous carriers of the same mutation. On DOL 38 treatment with anakinra was started, with prompt regression of fever and skin rash, decrease in inflammatory markers, increase in reticulocytes count and weight gain. Hypotonia improved but persisted. The patient was discharged from hospital on DOL 56 in good clinical conditions, with acute phase reactants within the normal range and mild hypotonia. She is now 4 months old, still on anakinra treatment without adverse events. Conclusion: Autoinflammatory diseases in the neonatal period are a diagnostic challenge. Clinical suspicion is crucial in order to perform specific laboratory and genetic testing and start appropriate treatment. Interstitial lung involvement may be present in MKD and, together with increased inflammatory markers, could be the first manifestation of the disease