The Role of Plasma Transfusion in Massive Bleeding: Protecting the Endothelial Glycocalyx?

Massive hemorrhage is a leading cause of death worldwide. During the last decade several retrospective and some prospective clinical studies have suggested a beneficial effect of early plasma-based resuscitation on survival in trauma patients. The underlying mechanisms are unknown but appear to involve the ability of plasma to preserve the endothelial glycocalyx. In this mini-review, we summarize current knowledge on glycocalyx structure and function, and present data describing the impact of hemorrhagic shock and resuscitation fluids on glycocalyx. Animal studies show that hemorrhagic shock leads to glycocalyx shedding, endothelial inflammatory changes, and vascular hyper-permeability. In these animal models, plasma administration preserves glycocalyx integrity and functions better than resuscitation with crystalloids or colloids. In addition, we briefly present data on the possible plasma components responsible for these effects. The endothelial glycocalyx is increasingly recognized as a critical component for the physiological vasculo-endothelial function, which is destroyed in hemorrhagic shock. Interventions for preserving an intact glycocalyx shall improve survival of trauma patients

Two interacting Hofstadter butterflies

The problem of two interacting particles in a quasiperiodic potential is addressed. Using analytical and numerical methods, we explore the spectral properties and eigenstates structure from the weak to the strong interaction case. More precisely, a semiclassical approach based on non commutative geometry techniques permits to understand the intricate structure of such a spectrum. An interaction induced localization effect is furthermore emphasized. We discuss the application of our results on a two-dimensional model of two particles in a uniform magnetic field with on-site interaction.Comment: revtex, 12 pages, 11 figure

Hydrological Uncertainty and Hydropower: New Methods to Optimize the Performance of the Plant☆

Abstract Hydrological uncertainty due to daily flow variability and to the effect of climate change on water resources is a critical topic in the feasibility evaluations of hydro-power projects, especially for run-of-river power plant. The effect produced by these factors on the annual energy output of such type of plant was investigated. Empirical methods to improve the performance of the plant are proposed, which enable the choice of the most suitable design flow (Q d ) according to the hydrological features of the river, to the frequency of dry and wet years in the basin and to the target energy production

Double butterfly spectrum for two interacting particles in the Harper model

We study the effect of interparticle interaction $U$ on the spectrum of the Harper model and show that it leads to a pure-point component arising from the multifractal spectrum of non interacting problem. Our numerical studies allow to understand the global structure of the spectrum. Analytical approach developed permits to understand the origin of localized states in the limit of strong interaction $U$ and fine spectral structure for small $U$.Comment: revtex, 4 pages, 5 figure

Levantamento sobre genótipos de mandioca utilizados pelos agricultores de pequena escala, na baixada cuiabana, MT

Foi realizado um levantamento sobre os genótipos de mandioca utilizados pelos agricultores na Baixada Cuiabana, região que compreende 14 municípios entorno de Cuiabá, composto de muitos agricultores tradicionais. O MT é um dos centros de origem e diversificação da Manihot esculenta, sendo essa região detentora de uma grande tradição de produção de farinha, devido ao alto consumo pela sua culinária regional. A agricultura familiar desempenha papel fundamental na diversidade de plantas, representando uma forma importante de conservação in situ. Foi aplicado um questionário para os técnicos da EMPAER (Empresa Extensão Rural do Mato Grosso) que atuam na região para identificar os genótipos de mandioca de mesa e de indústria. Foram citados 11, todos eles crioulos os quais foram: ?Igarapé Vermelha?, ?Liberata?, ?Sopão?, ?Juriti?, ?Broto branco?, ?Mansa?, ?Broto roxo?, ?Cacau?, ?Uva?, ?Galhadeira? e ?Olho junto?. Não foram mencionados genótipos melhorados, como da Embrapa ou IAC. Os genótipos ?Liberata? e ?Juriti? foram citados tanto para consumo em mesa, como para indústria na fabricação de farinha, indicando dupla aptidão. Porém, ?Liberata? foi o mais mencionado, sendo citados por técnicos de todos os municípios. Os agricultores tradicionais dessa região são mantenedores da diversidade local

Exploring the boundaries in an interdisciplinary context through the Family Resemblance Approach: The Dialogue Between Physics and Mathematics

Among the relevant aspects of the family resemblance approach (FRA), our study focuses on the potential of the approach to elaborate on disciplinary identities in an interdisciplinary context, specifically regarding the interplay between physics and mathematics. We present and discuss how the FRA wheel can be used and intertwined with the framework of boundary objects and boundary crossing mechanisms (Akkerman & Bakker, Review of Educational Research, 81, 132–169, 2011), which is well-known in STEM education for dealing with interdisciplinarity. The role of the FRA discussed in the article is dual: both practical and theoretical. It is practical in that we show how its use, in combination with the Akkerman and Bakker framework, appears effective in fostering productive discussions among prospective teachers on disciplinary identities and interdisciplinarity in historical cases. It is theoretical in that the combination of the two frameworks provides the vocabulary to characterise the ‘ambiguous nature’ of interdisciplinarity: like boundaries, interdisciplinarity both separates disciplines, making their identities emerge, and connects them, fostering mechanisms of crossing and transgressing the boundaries. This empirical study reveals how the theoretical elaboration took advantage of the prospective teachers’ contributions. We initially presented the FRA to characterise disciplinary identities, but the prospective teachers highlighted its potential to characterise also the boundary zone and the dialogue between physics and mathematics. The data analysis showed that the combination of the two frameworks shaped a complex learning space where there was room for very different epistemic demands of the prospective teachers: from those who feel better within the identity cores of the disciplines, to those who like to inhabit the boundary zone and others who like to re-shape boundary spaces and move dynamically across them

Making sense of youth futures narratives: Recognition of emerging tensions in students' imagination of the future

In this era of great uncertainty, imagining the future may be challenging, especially for young people. In science education, the interest in future-oriented education is now emerging, research needs, however, to keep eyes on youngsters' future perceptions and on the development of a future literacy. In this article, starting from a sample of individual students' narratives about their future daily life in 2040, we aim to delineate which ways of grappling with the future can be observed in the essays and which methodological tools are suited to operationalize their identification and characterization. The analysis led to the definition of "polarization" and "complexification" attitudes that represent the ways in which the students' narratives are positioned with respect to a bunch of dichotomies: personal-societal, functional-aesthetics oriented, good-bad, natural-artificial, and certain-uncertain. Moreover, with this study, we provide a contribution to the methodological reflection that deals with the collection and analysis of data, when students' future perceptions need to be investigated. Discussing the limits of the current data collection tool, we introduce the design of a SenseMaker (R) questionnaire which contributed to feeding a collaboration with #OurFutures project, recently launched by the European Commission to collect future narratives all around Europe

Reactive Metals as Energy Storage and Carrier Media: Use of Aluminum for Power Generation in Fuel Cell-Based Power Plants

In recent years, the energy production sector has experienced a growing interest in new energy vectors enabling energy storage and, at the same time, intersectoral energy applications among users. Hydrogen is one of the most promising energy storage and carrier media featuring a very high gravimetric energy density, but a rather low volumetric energy density. To this regard, this study focuses on the use of aluminum as energy storage and carrier medium, offering high volumetric energy density (23.5 kWh L$^{-1}$), ease to transport and stock (e.g., as ingots), and is neither toxic nor dangerous when stored. In addition, mature production and recycling technologies exist for aluminum. Herein, the performance of power systems driven by aluminum powder in terms of electrical efficiency (η$_{(I)}$) and round‐trip efficiency (RTE) is analyzed. Along with the additional advantages relating to high volumetric energy density, and safety and management aspects, the aluminum‐based technology appears to outperform the power‐to‐power systems based on hydrogen and liquid fuels