How to create an innovation accelerator

Abstract.: The purpose of this White Paper of the EU Support Action "Visioneer” (see www.visioneer.ethz.ch) is to address the following goals: 1. Identify new ways of publishing, evaluating, and reporting scientific progress. 2. Promote ICT solutions to increase the awareness of new emerging trends. 3. Invent tools to enhance Europe's innovation potential. 4. Develop new strategies to support a sustainable technological development. 5. Lay the foundations for new ways to reach societal benefits and respond to industrial needs using IC

From social data mining to forecasting socio-economic crises

Abstract.: The purpose of this White Paper of the EU Support Action "Visioneer”(see www.visioneer.ethz.ch) is to address the following goals: 1. Develop strategies to quickly increase the objective knowledge about social and economic systems. 2. Describe requirements for efficient large-scale scientific data mining of anonymized social and economic data. 3. Formulate strategies how to collect stylized facts extracted from large data set. 4. Sketch ways how to successfully build up centers for computational social science. 5. Propose plans how to create centers for risk analysis and crisis forecasting. 6. Elaborate ethical standards regarding the storage, processing, evaluation, and publication of social and economic dat

From social simulation to integrative system design

Abstract.: The purpose of this White Paper of the EU Support Action "Visioneer” (see www.visioneer.ethz.ch) is to address the following goals: 1.Develop strategies to build up social simulation capacities.2.Suggest ways to build up an "artificial societies” community that aims at simulating real and alternative societies by means of supercomputers, grid or cloud computing.3.Derive proposals to establish centers for integrative systems desig

Understanding, creating, and managing complex techno-socio-economic systems: Challenges and perspectives

Abstract.: This contribution reflects on the comments of Peter Allen [1], Bikas K. Chakrabarti [2], Péter Érdi [3], Juval Portugali [4], Sorin Solomon [5], and Stefan Thurner [6] on three White Papers (WP) of the EU Support Action Visioneer (www.visioneer.ethz.ch). These White Papers are entitled "From Social Data Mining to Forecasting Socio-Economic Crises” (WP 1) [7], "From Social Simulation to Integrative System Design” (WP 2) [8], and "How to Create an Innovation Accelerator” (WP 3) [9]. In our reflections, the need and feasibility of a "Knowledge Accelerator” is further substantiated by fundamental considerations and recent events around the globe. newpara The Visioneer White Papers propose research to be carried out that will improve our understanding of complex techno-socio-economic systems and their interaction with the environment. Thereby, they aim to stimulate multi-disciplinary collaborations between ICT, the social sciences, and complexity science. Moreover, they suggest combining the potential of massive real-time data, theoretical models, large-scale computer simulations and participatory online platforms. By doing so, it would become possible to explore various futures and to expand the limits of human imagination when it comes to the assessment of the often counter-intuitive behavior of these complex techno-socio-economic-environmental systems. In this contribution, we also highlight the importance of a pluralistic modeling approach and, in particular, the need for a fruitful interaction between quantitative and qualitative research approaches. newpara In an appendix we briefly summarize the concept of the FuturICT flagship project, which will build on and go beyond the proposals made by the Visioneer White Papers. EU flagships are ambitious multi-disciplinary high-risk projects with a duration of at least 10 years amounting to an envisaged overall budget of 1 billion EUR [10]. The goal of the FuturICT flagship initiative is to understand and manage complex, global, socially interactive systems, with a focus on sustainability and resilienc

How to Create an Innovation Accelerator

Too many policy failures are fundamentally failures of knowledge. This has become particularly apparent during the recent financial and economic crisis, which is questioning the validity of mainstream scholarly paradigms. We propose to pursue a multi-disciplinary approach and to establish new institutional settings which remove or reduce obstacles impeding efficient knowledge creation. We provided suggestions on (i) how to modernize and improve the academic publication system, and (ii) how to support scientific coordination, communication, and co-creation in large-scale multi-disciplinary projects. Both constitute important elements of what we envision to be a novel ICT infrastructure called "Innovation Accelerator" or "Knowledge Accelerator".Comment: 32 pages, Visioneer White Paper, see http://www.visioneer.ethz.c

From Social Data Mining to Forecasting Socio-Economic Crisis

Socio-economic data mining has a great potential in terms of gaining a better understanding of problems that our economy and society are facing, such as financial instability, shortages of resources, or conflicts. Without large-scale data mining, progress in these areas seems hard or impossible. Therefore, a suitable, distributed data mining infrastructure and research centers should be built in Europe. It also appears appropriate to build a network of Crisis Observatories. They can be imagined as laboratories devoted to the gathering and processing of enormous volumes of data on both natural systems such as the Earth and its ecosystem, as well as on human techno-socio-economic systems, so as to gain early warnings of impending events. Reality mining provides the chance to adapt more quickly and more accurately to changing situations. Further opportunities arise by individually customized services, which however should be provided in a privacy-respecting way. This requires the development of novel ICT (such as a self- organizing Web), but most likely new legal regulations and suitable institutions as well. As long as such regulations are lacking on a world-wide scale, it is in the public interest that scientists explore what can be done with the huge data available. Big data do have the potential to change or even threaten democratic societies. The same applies to sudden and large-scale failures of ICT systems. Therefore, dealing with data must be done with a large degree of responsibility and care. Self-interests of individuals, companies or institutions have limits, where the public interest is affected, and public interest is not a sufficient justification to violate human rights of individuals. Privacy is a high good, as confidentiality is, and damaging it would have serious side effects for society.Comment: 65 pages, 1 figure, Visioneer White Paper, see http://www.visioneer.ethz.c

Lipid (per) oxidation in mitochondria:an emerging target in the ageing process?

Lipids are essential for physiological processes such as maintaining membrane integrity, providing a source of energy and acting as signalling molecules to control processes including cell proliferation, metabolism, inflammation and apoptosis. Disruption of lipid homeostasis can promote pathological changes that contribute towards biological ageing and age-related diseases. Several age-related diseases have been associated with altered lipid metabolism and an elevation in highly damaging lipid peroxidation products; the latter has been ascribed, at least in part, to mitochondrial dysfunction and elevated ROS formation. In addition, senescent cells, which are known to contribute significantly to age-related pathologies, are also associated with impaired mitochondrial function and changes in lipid metabolism. Therapeutic targeting of dysfunctional mitochondrial and pathological lipid metabolism is an emerging strategy for alleviating their negative impact during ageing and the progression to age-related diseases. Such therapies could include the use of drugs that prevent mitochondrial uncoupling, inhibit inflammatory lipid synthesis, modulate lipid transport or storage, reduce mitochondrial oxidative stress and eliminate senescent cells from tissues. In this review, we provide an overview of lipid structure and function, with emphasis on mitochondrial lipids and their potential for therapeutic targeting during ageing and age-related disease

Air pollution and child development in India

International audienceIn this paper, we study the impact of air pollution on child growth in India. We rely on wind direction to capture quasi-random variation in three main criteria air pollutants. We show that an increase in the average concentration of fine particulate matter by one standard deviation is accountable for almost 5 and 2.4 percentage points of stunting and severe stunting rates, respectively. We also find that ozone and carbon monoxide impact weight-related outcomes. Stunting has critical long-term health and economic consequences; through its impact on stunting, pollution exacerbates the height premium in earnings, with girls being more adversely affected than boys in India. © 2022 Elsevier Inc