The peculiar Na-O anticorrelation of the bulge globular cluster NGC 6440

Context. Galactic Globular Clusters (GCs) are essential tools to understand the earliest epoch of the Milky Way, since they are among the oldest objects in the Universe and can be used to trace its formation and evolution. Current studies using high resolution spectroscopy for many stars in each of a large sample of GCs allow us to develop a detailed observational picture about their formation and their relation with the Galaxy. However, it is necessary to complete this picture by including GCs that belong to all major Galactic components, including the Bulge. Aims. Our aim is to perform a detailed chemical analyses of the bulge GC NGC 6440 in order to determine if this object has Multiple Populations (MPs) and investigate its relation with the Bulge of the Milky Way and with the other Galactic GCs, especially those associated with the Bulge, which are largely poorly studied. Methods. We determined the stellar parameters and the chemical abundances of light elements (Na, Al), iron-peak elements (Fe, Sc, Mn, Co, Ni), $\alpha$-elements (O, Mg, Si, Ca, Ti) and heavy elements (Ba, Eu) in seven red giant members of NGC 6440 using high resolution spectroscopy from FLAMES@UVES. Results. We found a mean iron content of [Fe/H]=-0.50$\pm$0.03 dex in agreement with other studies. We found no internal iron spread. On the other hand, Na and Al show a significant intrinsic spread, but the cluster has no significant O-Na anticorrelation nor exhibits a Mg-Al anticorrelation. The $\alpha$-elements show good agreement with the Bulge field star trend, although they are at the high alpha end and are also higher than those of other GCs of comparable metallicity. The heavy elements are dominated by the r-process, indicating a strong contribution by SNeII. The chemical analysis suggests an origin similar to that of the Bulge field stars.Comment: 12 pages, 13 figures, Accepted for publication in A&

Globular Cluster Systems in Brightest Cluster Galaxies. III: Beyond Bimodality

We present new deep photometry of the rich globular cluster (GC) systems around the Brightest Cluster Galaxies UGC 9799 (Abell 2052) and UGC 10143 (Abell 2147), obtained with the HST ACS and WFC3 cameras. For comparison, we also present new reductions of similar HST/ACS data for the Coma supergiants NGC 4874 and 4889. All four of these galaxies have huge cluster populations (to the radial limits of our data, comprising from 12000 to 23000 clusters per galaxy). The metallicity distribution functions (MDFs) of the GCs can still be matched by a bimodal-Gaussian form where the metal-rich and metal-poor modes are separated by ~0.8 dex, but the internal dispersions of each mode are so large that the total MDF becomes very broad and nearly continuous from [Fe/H] = -2.4 to Solar. There are, however, significant differences between galaxies in the relative numbers of \emph{metal-rich} clusters, suggesting that they underwent significantly different histories of mergers with massive, gas-rich halos. Lastly, the proportion of metal-poor GCs rises especially rapidly outside projected radii R > 4 R_eff, suggesting the importance of accreted dwarf satellites in the outer halo. Comprehensive models for the formation of GCs as part of the hierarchical formation of their parent galaxies will be needed to trace the systematic change in structure of the MDF with galaxy mass, from the distinctly bimodal form in smaller galaxies up to the broad continuum that we see in the very largest systems.Comment: In press for Astrophysical Journa

Chemical analysis of NGC 6528: one of the most metal-rich bulge globular cluster

The Bulge Globular Clusters (GCs) are key tracers of this central ancient component of our Galaxy. It is essential to understand their formation and evolution to study that of the bulge, as well as their relationship with the other Galactic GC systems (halo and disk GCs). Our main goals are to obtain detailed abundances for a sample of seven red giant members of NGC 6528 in order to characterize its chemical composition and study the relationship of this GC with the bulge, and with other bulge, halo and disk GCs. Moreover, we analyze this cluster$'$s behavior associated with the Multiple Populations (MPs) phenomenon. We obtained the stellar parameters and chemical abundances of light elements (Na, Al), iron-peak elements (V, Cr, Mn, Fe, Co, Ni, Cu), {\alpha}-elements (O, Mg, Si, Ca, Ti) and heavy elements (Zr, Ba, Eu) in seven red giant members of NGC 6528 using high resolution spectroscopy from FLAMES-UVES. We obtained in six stars of our sample a mean iron content of [Fe/H]=-0.14+/-0.03 dex, in good agreement with other studies. We found no significant internal iron spread. We detected one candidate variable star, which was excluded from the mean in iron content, we derived a metallicity in this star of [Fe/H]=-0.55+/-0.04 dex. Moreover, we found no extended O-Na anticorrelation but instead only an intrinsic Na spread. In addition, NGC 6528 does not exhibit a Mg-Al anticorrelation, and no significant spread in either Mg or Al. The {\alpha} and iron-peak elements show good agreement with the bulge field star trend. The heavy elements are slightly dominated by the r-process. The chemical analysis suggests an origin and evolution similar to that of typical old Bulge field stars. Finally, we find remarkable agreement in the chemical patterns of NGC 6528 and another bulge GC, NGC 6553, suggesting a similar origin and evolution.Comment: Accepted for publication in A&A. 12 pages, 13 figures, 4 table

Ultra-deep GEMINI near-infrared observations of the bulge globular cluster NGC 6624

We used ultra-deep $J$ and $K_s$ images secured with the near-infrared GSAOI camera assisted by the multi-conjugate adaptive optics system GeMS at the GEMINI South Telescope in Chile, to obtain a ($K_s$, $J-K_s$) color-magnitude diagram (CMD) for the bulge globular cluster NGC 6624. We obtained the deepest and most accurate near-infrared CMD from the ground for this cluster, by reaching $K_s$ $\sim$ 21.5, approximately 8 magnitudes below the horizontal branch level. The entire extension of the Main Sequence (MS) is nicely sampled and at $K_s$ $\sim$ 20 we detected the so-called MS "knee" in a purely near-infrared CMD. By taking advantage of the exquisite quality of the data, we estimated the absolute age of NGC 6624 ($t_{age}$ = 12.0 $\pm$ 0.5 Gyr), which turns out to be in good agreement with previous studies in the literature. We also analyzed the luminosity and mass functions of MS stars down to M $\sim$ 0.45 M$_{\odot}$ finding evidence of a significant increase of low-mass stars at increasing distances from the cluster center. This is a clear signature of mass segregation, confirming that NGC 6624 is in an advanced stage of dynamical evolution.Comment: Accepted for publication by ApJ. 39 pages, 19 figures, 1 tabl

A panchromatic view of the bulge globular cluster NGC 6569

We used high-resolution optical HST/WFC3 and multi-conjugate adaptive optics assisted GEMINI GeMS/GSAOI observations in the near-infrared to investigate the physical properties of the globular cluster NGC 6569 in the Galactic bulge. We have obtained the deepest purely NIR color-magnitude diagram published so far for this cluster using ground-based observations, reaching $K_{s}$ $\approx$ 21.0 mag (two magnitudes below the main-sequence turn-off point). By combining the two datasets secured at two different epochs, we determined relative proper motions for a large sample of individual stars in the center of NGC 6569, allowing a robust selection of cluster member stars. Our proper motion analysis solidly demonstrates that, despite its relatively high metal content, NGC 6569 hosts some blue horizontal branch stars. A differential reddening map has been derived in the direction of the system, revealing a maximum color excess variation of about $\delta E(B-V)$ $\sim$ 0.12 mag in the available field of view. The absolute age of NGC 6569 has been determined for the first time. In agreement with the other few bulge globular clusters with available age estimates, NGC 6569 turns out to be old, with an age of about 12.8 Gyr, and a typical uncertainty of 0.8-1.0 Gyr.Comment: 25 pages, 16 Figures, 1 Table. Accepted for publication in Ap

Immunological evaluation of the new stable ultrasound contrast agent LK565: a phase one clinical trial

BACKGROUND: Ultrasound contrast agents (UCAs) allow the enhancement of vascular definition, thereby providing more diagnostic information. LK565 is a new second-generation UCA based on synthetic polymers of aspartic acid which is eliminated from the blood stream via phagocytosis. LK565 forms very stable air-filled microspheres and is capable of repeated passage through the pulmonary capillary bed after peripheral intravenous injection. This characteristic allows examination of the cardiac function or extracardiac vessel abnormalities up to 15 minutes. METHODS: A phase one clinical study was conducted on 15 healthy volunteers to identify the development of an undesirable immune response. Phagocytosis capacity, TNF-α secretion, and MHC class II upregulation of monocytes was monitored, as well as microsphere specific antibody development (IgM, IgG). Furthermore, the kinetics of the activation surface markers CD69, CD25, CD71, and CD11b on leukocytes were analyzed. RESULTS: Due to LK565-metabolism the administration of the UCA led to saturation of phagocytes which was reversible after 24 hrs. Compared to positive controls neither significant TNF-α elevation, neither MHC class II and activation surface markers upregulation, nor specific antibody development was detectable. CONCLUSION: The administration of LK565 provides a comfortable duration of signal enhancement, esp. in echocardiography, without causing a major activation cascade or triggering an adaptive immune response. To minimize the risk of undesirable adverse events such as anaphylactoid reactions, immunological studies should be included in clinical trials for new UCAs. The use of LK565 as another new ultrasound contrast agent should be encouraged as a safe means to provide additional diagnostic information

The Globular Cluster System of NGC 1399: III. VLT Spectroscopy and Database

Radial velocities of 468 globular clusters around NGC 1399, the central galaxy in the Fornax cluster, have been obtained with FORS2 and the Mask Exchange Unit (MXU) at the ESO Very Large Telescope. This is the largest sample of globular cluster velocities around any galaxy obtained so far. The mean velocity uncertainty is 50 km/sec. This data sample is accurate and large enough to be used in studies of the mass distribution of NGC 1399 and the properties of its globular cluster system. Here we describe the observations, the reduction procedure, and discuss the uncertainties of the resulting velocities. The complete sample of cluster velocities which is used in a dynamical study of NGC 1399 is tabulated. A subsample is compared with previously published values.Comment: 34 pages, 9 figures, 2 tables, accepted by A

Communications Biophysics

Contains research objectives and reports on three research projects

The Space Interferometry Mission Astrometric Grid Giant-Star Survey. I. Stellar Parameters and Radial Velocity Variability

We present results from a campaign of multiple epoch echelle spectroscopy of relatively faint (V = 9.5-13.5 mag) red giants observed as potential astrometric grid stars for the Space Interferometry Mission (SIM PlanetQuest). Data are analyzed for 775 stars selected from the Grid Giant Star Survey spanning a wide range of effective temperatures (Teff), gravities and metallicities. The spectra are used to determine these stellar parameters and to monitor radial velocity (RV) variability at the 100 m/s level. The degree of RV variation measured for 489 stars observed two or more times is explored as a function of the inferred stellar parameters. The percentage of radial velocity unstable stars is found to be very high -- about 2/3 of our sample. It is found that the fraction of RV-stable red giants (at the 100 m/s level) is higher among stars with Teff \sim 4500 K, corresponding to the calibration-independent range of infrared colors 0.59 < (J-K_s)_0 < 0.73. A higher percentage of RV-stable stars is found if the additional constraints of surface gravity and metallicity ranges 2.3< log g < 3.2 and -0.5 < [Fe/H] < -0.1, respectively, are applied. Selection of stars based on only photometric values of effective temperature (4300 K < Teff < 4700 K) is a simple and effective way to increase the fraction of RV-stable stars. The optimal selection of RV-stable stars, especially in the case when the Washington photometry is unavailable, can rely effectively on 2MASS colors constraint 0.59 < (J-K_s)_0 < 0.73. These results have important ramifications for the use of giant stars as astrometric references for the SIM PlanetQuest.Comment: Astronomical Journal, in press, 22 pages, 11 Postscript figures, uses aastex.cl

Stellar luminosity functions of rich star clusters in the Large Magellanic Cloud

We show the results of deep V and I HST photometry of 6 rich star clusters in the Large Magellanic Cloud with different ages and metallicities. The number of stars with measured magnitudes in each cluster varies from about 3000 to 10000. We build stellar density and surface brightness profiles for the clusters and extract half-light radii and other structural parameters for each. We also obtain luminosity functions, Phi (Mv), down to Mv ~ 6 (m/msun > 0.6), and investigate their dependence with distance from the cluster centre well beyond their half-light radius. In all clusters we find a systematic increase in the luminosity function slope with radial distance from the centre. Among the clusters displaying significant mass segregation are the two youngest in the sample: NGC 1805 and NGC 1818. For these two clusters we obtain present-day mass functions. The NGC 1818 mass function is in excellent agreement with that derived by other authors, also using HST data. They young cluster mass function slopes differ, that of NCG 1805 being systematically steeper than NGC 1818. Since these are very young stellar systems (age < 40 Myrs), these variations may reflect the initial conditions rather than evolution due to internal dynamics.Comment: 10 pages, 24 figure