Assessment of pharmacological activity and bioavailability of the new derivative 1,3,4-thiadiazole

Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid. In animal experiments, acute toxicity, pharmacological activity and bioavailability of acexazolamide were evaluate

Conditioned Unitary Transformation on biphotons

A conditioned unitary transformation ($90^o$ polarization rotation) is performed at single-photon level. The transformation is realized by rotating polarization for one of the photons of a polarization-entangled biphoton state (signal photon) by means of a Pockel's cell triggered by the detection of the other (idler) photon after polarization selection. As a result, polarization degree for the signal beam changes from zero to the value given by the idler detector quantum efficiency. This result is relevant to practical realization of various quantum information schemes and can be used for developing a new method of absolute quantum efficiency calibration

Design and evaluation of pharmacological properties of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid

The use of the pharmacophoric approach is a promising direction for modifying the chemical structure of 2-propylpentanoic (valproic) acid in order to obtain new drug

Коэффициент шума: оценка шумовых характеристик радиофотонного тракта на основе результатов измерения коэффициента шума

In radiophotonic microwave transmission systems, as in any radioelectronic systems, noise characteristics determine the potential of accuracy and range. As a measure of the difference between the noise characteristics of optoelectronic microwave signal converters from ideal ones, the use of the noise figures of the elements included in their composition is proposed. The effect of such a criterion is demonstrated by the example of the optoelectronic microwave oscillator (OEO). Based on the results of the study of the optoelectronic microwave oscillator noise parameters quantitative characteristics of the conversion of the OEO elements noise sources into phase and amplitude fluctuations of the output microwave oscillation are obtained. The analysis of the interaction of the OEO elements noise with the microwave harmonic oscillation is performed. The technique for measuring the noise conversion characteristics using the noise figure has been developed. The results of measuring characteristics of the interaction of harmonic oscillation with the optoelectronic components additive and multiplicative noise of optoelectronic components are presented. Based on the values of the noise figure, the possibilities of reducing the noise levels of microwave signal converters are evaluated and recommendations are made to reduce the influence of the noise.В радиофотонных системах передачи СВЧ-сигналов, как и в любых радиоэлектронных системах, шумовые характеристики определяют потенциальные возможности по точности и дальности действия. Предложено в качестве меры отличия шумовых характеристик оптоэлектронных преобразователей СВЧ-сигналов от идеала использовать коэффициенты шума элементов, входящих в их состав. На примере оптоэлектронного (ОЭ) СВЧ-генератора показано действие такого критерия. Опираясь на результаты исследования шумовых параметров ОЭ СВЧ-генератора, получены количественные характеристики преобразования источников шумов элементов, входящих в состав ОЭ генератора, во флуктуации фазы и амплитуды выходного СВЧ-колебания. Выполнен анализ взаимодействия шумов элементов ОЭ генератора с СВЧ гармоническим колебанием. Разработана методика измерения характеристик преобразования шумов с использованием коэффициента шума. Приведены результаты измерения шумовых характеристик взаимодействия гармонического колебания с аддитивным и мультипликативным шумом оптоэлектронных компонентов. По значениям коэффициента шума оцениваются возможности уменьшения уровней шумов преобразователей СВЧ-сигналов и даются рекомендации по уменьшению влияния шумов

Status of the FLUTE RF System Upgrade

FLUTE (Ferninfrarot Linac- Und Test-Experiment) is a compact versatile linac-based accelerator test facility at KIT. Its main goal is to serve as a platform for a variety of accelerator studies and to generate strong ultra-short THz pulses for photon science. It will also serve as an injector for a Very Large Acceptance compact Storage Ring (VLA-cSR), which will be realized at KIT in the framework of the compact STorage Ring for Accelerator Research and Technology (cSTART) project. To achieve acceleration of electrons in the RF photoinjector and LINAC (from FLUTE) with high stability, it is necessary to provide stable RF power. For this goal, an upgrade of the existing RF system design has been proposed and is currently being implemented. This contribution will report on the updated RF system design and the commissioning status of the new RF system components

Probing AGN with spectropolarimetry: accretion disk and SMBH parameters

The interaction of a supermassive black hole with the matter of an accretion disk in the presence of a magnetic field is the key mechanism of energy release in active galactic nuclei. However, determining the physical parameters of this system, such as the spin and mass of the black hole, the shape and parameters of the rotation of the accretion disk, and the geometry of the magnetic field in the accretion disk is a complex and not completely solved problem. We have previously shown, based on our numerical models, that these estimates can be obtained from just three parameters: the black hole mass, bolometric luminosity, and optical polarization. In this paper, we estimate the accretion disk and black hole parameters for a sample of 14 type 1 Seyfert galaxies. Using the spectropolarimetric data obtained by us, we selected only those objects in which the polarization of optical radiation is generated mainly by the mechanism in the accretion disk. Despite the small statistics, our results for such a sample are consistent with our previous conclusions and show a discrepancy between the disk magnetic field parameters and the classical Shakura-Sunyaev disk model.Comment: 9 pages, 5 figure