76 research outputs found
Ultrastructural changes in renal parenchyma with renal cell carcinoma
Pasichnyk S., Stakhovsky O., Gozhenko A., Pasichnyk M., Voronina O. Ultrastructural changes in renal parenchyma with renal cell carcinoma. Journal of Education, Health and Sport. 2018;8(6):446-451. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1495561
http://ojs.ukw.edu.pl/index.php/johs/article/view/6319
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
Β© The Author(s) 2018;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.06.2018. Revised: 12.06.2018. Accepted: 29.06.2018.
Ultrastructural changes in renal parenchyma with renal cell carcinoma
S. Pasichnyk1, O. Stakhovsky2, A. Gozhenko3, M. Pasichnyk1, O. Voronina4
1Lviv National Medical University named after Danylo Halytsky, Lviv, Ukraine
Department of urology FPGE
2National Cancer Institute, Kiyv
3Ukrainian Research Institute of Transport Medicine of Ministry of Health of Ukraine, Odessa
4NSC Institute of Biology and Medicine, Kiyv
Abstract
In recent years, there has been a significant increase in incidence of the renal cell carcinoma (RCC). In the structure of cancer, this pathology is on 10th place. The surgical treatment is the most radical and most effective method of management of this disease. Currently renal resection has become a desirable alternative to radical nephrectomy for tumors of the T1 stage [6, 7, 8, 9]. Nephron-sparing interventions, compared to radical nephrectomy, showed an equivalent cancer outcome in tumors < 4 cm in diameter [1, 10]. However, there is an opinion [2] that in the intact part of the organ due to an increased functional load various pathomorphological changes may occur [3, 4 ,7]. Although, it is believed that in this cohort of patients there are no pathomorphological changes and only in rare cases, distant functional changes can be observed [5, 2].
Key words: renal cell carcinoma, nephron, nephrectomy, nephron-sparing surger
Endothelial dysfunction in patients after COVID-19
Relevance: Over the past two years, the COVID-19 infection has gained unprecedented relevance at the global level. All countries are spending significant resources in the fight against COVID-19 [1 2].
The purpose of the work is to clarify the issue of the state of the kidneys in the distant post-covid period (after 2-3 months), we conducted a study of the kidneys simultaneously with the desquamation of the endothelium, as one of the probable mechanisms of the nephrotic effect of the COVID-19 virus.
Materials and methods: 29 people participated in the study. Patients with post-covid syndrome (n=10) were treated on an outpatient basis at the "KNP "Center of primary medical and sanitary (medical and sanitary) care No. 3, Odesa" of the Odesa City Council" in the period from 2020 to 2021. The control group consisted of patients without cardiovascular and endocrine disorders, comparable in terms of gender and age, who were examined in 2018 at the Odesa Regional Clinical Medical Center of the Odesa Regional Council.
Endothelial dysfunction "ED" was determined by the intensity of desquamation of the endothelium according to the method of J. Hladovec as modified by M.M. Petryschev. and other. (2001).
Β Β Β Β Β Β Β Β Β Β Statistical analysis was performed using Status software [https://status-please.herokuapp.com/]. Mean values ββ(M) and its standard deviation (SD) were used to describe quantitative data, and percentages were used for qualitative data. For comparison, data were presented as M and standard error of the mean (SEM). Analysis of normality was performed using the Shapiro-Wilk test. Levene's test was used to assess homogeneity of variances. Differences between groups were determined using Student's t-test and one-way analysis of variance (ANOVA). The relationship and presence of correlation between the studied parameters was determined using the Pearson correlation coefficient (r). The correlation coefficient in the range of 0.5β€|r|<1 indicated a strong correlation relationship, 0.3β€|r|<0.5 β a relationship of medium strength, 0<|r|<0.3 β on a weak correlation. Statistical significance was established only at the level of p < 0.05.
Results: 17 men and 12 women aged from 32 to 80 years who suffered from a disease of moderate severity participated in the study. The average age of the group of patients with post-covid syndrome (n=9) is 55.9Β±14.47 years, the average age of the control group (n=20) is 55.95Β±14.47 years.
There were no complaints from the urinary system in the examined patients. According to blood serum tests, it was established that the creatinine level among patients with post-covid syndrome was on average 113Β±11.91 ΞΌmol/l, the urea level was 8.11Β±1.2 mmol/l, the GFR level was 55.06Β±12, 19 ml/min/1.73. m2.
In the control group, the numbers were as follows: creatinine level was 73.2Β±8.5 ΞΌmol/l, mean urea level was 4.61 mmol/l, GFR was 94.78Β±13.76 ml/min/1.73 m2.
Conclusions:
2-3 months after the transfer of COVID-19, the examined patients show signs of chronic kidney disease.
After a disease with COVID-19, an increase in CEC is detected, which is a manifestation of endothelial dysfunction
Justification of the renoprotective action of the mixture of sodium chloride and sodium bicarbonate solutions in phenylhydrazine intoxication
The authors conducted a study on 35 white Wistar outbred rats to investigate the possibility of correcting acute kidney damage induced by the administration of phenylhydrazine at a dose of 100 mg/kg by introducing a mixture of sodium chloride and sodium bicarbonate solutions into the body.
The research results identified changes in the kidneys upon phenylhydrazine administration, including the loss of some capillary glomeruli, eosinophilic deposits in Bowman's spaces and tubular lumens, and lymphoid infiltration in the interstitium. Rats receiving a mixture of sodium chloride and sodium bicarbonate solutions in their drinking water showed positive changes in their kidneys: no loss of capillary glomeruli was observed, and eosinophilic deposits were absent in most tubules. Lymphocyte aggregation was only observed around some renal vessels. The authors suggest that the intake of additional sodium and bicarbonate into the body, along with alkalinization of the primary urine, promotes the excretion of hemolysis products caused by phenylhydrazine, which contributes to renoprotection and preservation of renal parenchyma
Theoretical foundations and innovative model of occupational health
Gozhenko A. I., Badyuk N. S., Lebedeva T. L., GoncharenkoΒ O.Β O.,Β Zukow W. Theoretical foundations and innovative model of occupational health. Journal of Education, Health and Sport. 2016;6(11):383-389. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.168237http://ojs.ukw.edu.pl/index.php/johs/article/view/4011Β Β Β The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7Β© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 01.11.2016. Revised 12.11.2016. Accepted: 23.11.2016.Β Β Β Theoretical foundations and innovative model of occupational healthΒ Gozhenko A. I.1, Badyuk N. S.1, Lebedeva T. L.1, GoncharenkoΒ O.Β O.1,Β Zukow W.2Β 1Ukrainian Research Institute of Transport Medicine,Β Odessa,Β Ukraine2Kazimierz Wielki University, Bydgoszcz, PolandΒ Β Β Β Β AbstractHealth is a basic human value. One of the main criteria for health is still a rate of a, which in civilizationβs countries is constantly decreasing, which causes the lengthening of life.However, along with this significantly changes the structure of morbidity: reduction of infectious diseases accompanied by increased infectious. All of these diseases can be divided into professional and vocational-conditioned.Β Β Β Key words: health, disease, occupational diseases, professional diseases due to
Cardio-renal mechanisms of adaptation in normal and with heart failure
The pathogenesis of chronic heart failure (CHF) is a complex multifactorial process, which is a close combination of manifestations of the effects on the cardiovascular system of the etiological factor (s) and the mobilization of a whole complex of compensatory mechanisms [30].
According to the first conceptual models (cardiac (1950s) and cardiorenal (1960s)) pathogenesis, the main role in the formation of CHF belonged to a decrease in cardiac contractility (systolic dysfunction), as well as electrolyte retention and body water. [4, 14, 39].
The aim of the study was to study the role of the renin-angiotensin-aldosterone system and the natriuretic hormone in adaptive changes in water-salt homeostasis with an increase in venous blood return to the heart in healthy and in patients with stable ischemic heart disease with chronic heart failure stage I (stage I).
The results of the study concluded: - in healthy individuals, an increase in venous return of blood to the heart (preload) in anti-orthostasis on the background of 0.5% water load is accompanied by adaptive changes in cardiohemodynamics, volemic homeostasis and neurohumoral regulation of water-salt metabolism, manifested by an increased influence of the parasympathetic department ANS, a decrease in heart rate, an increase in ASI while maintaining the IOC at the same level, an increase in diuresis, a decrease in the activity of the RAAS, an increase in the content of Ξ±-PNOG; - in patients with coronary artery disease with HNK I st. with an increase in preload at the 30th minute of anti-orthostasis, changes in cardio hemodynamics (decrease in IOC) and cardiac rhythmograms were revealed, indicating a depletion of myocardial reserve capacity and vegetative regulation of heart rhythm. The lack of heart rate dynamics and cardiac rhythmograms in anti-orthostasis reflects an increase in the activity of the sympathetic section of the autonomic nervous system in patients with coronary artery disease with the initial stage of HNK; - kidney reaction to anti-orthostasis and 0.5% water load in patients with coronary artery disease with HNK, I st. expressed in increased diuresis in the absence of changes in the activity of the RAAS, which indicates the predominance of antinatriuretic systems over natriuretic; - the earliest indicator of the development of heart failure in patients with coronary artery disease is sodium retention, aimed at increasing the BCC, venous return of blood to the heart and stimulation of the heterometric mechanism of Frank-Starling
ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΌΠΎΡΡΠΎΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½ΠΈΡ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΡΠΎΠ·Π²ΠΈΡΠΊΡ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ ΠΌΠ΅ΡΠ°Π»ΠΎΠ½Π΅ΡΡΠΎΠΏΠ°ΡΡΠΉ = The study of morphofunctional features of the development of experimental metallonephropathy
Gozhenko A. I., Lugovskoy S. P., Samokhina N. A. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΌΠΎΡΡΠΎΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½ΠΈΡ
ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΡΠΎΠ·Π²ΠΈΡΠΊΡ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠ°Π»ΠΎΠ½Π΅ΡΡΠΎΠΏΠ°ΡΡΠΉ = The study of morphofunctional features of the development of experimental metallonephropathy. Journal of Education, Health and Sport. 2016;6(4):287-296. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.50201http://ojs.ukw.edu.pl/index.php/johs/article/view/3473Β The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7Β© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016.Β ΠΠΠ‘ΠΠΠΠΠΠΠΠ― ΠΠΠ Π€ΠΠ€Π£ΠΠΠ¦ΠΠΠΠΠΠ¬ΠΠΠ₯ ΠΠ‘ΠΠΠΠΠΠΠ‘Π’ΠΠ Π ΠΠΠΠΠ’ΠΠ£ ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’ΠΠΠ¬ΠΠΠ₯ ΠΠΠ’ΠΠΠΠΠΠ€Π ΠΠΠΠ’ΠΠ Β Π. Π. ΠΠΎΠΆΠ΅Π½ΠΊΠΎ, Π‘. Π. ΠΡΠ³ΠΎΠ²ΡΡΠΊΠΈΠΉ, Π. Π. Π‘Π°ΠΌΠΎΡ
ΡΠ½Π° Β ΠΠ΅ΡΠΆΠ°Π²Π½Π΅ ΠΏΡΠ΄ΠΏΡΠΈΡΠΌΡΡΠ²ΠΎ Β«Π£ΠΊΡΠ°ΡΠ½ΡΡΠΊΠΈΠΉ Π½Π°ΡΠΊΠΎΠ²ΠΎ-Π΄ΠΎΡΠ»ΡΠ΄Π½ΠΈΠΉ ΡΠ½ΡΡΠΈΡΡΡΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΡ ΠΠΠ Π£ΠΊΡΠ°ΡΠ½ΠΈΒ», ΠΌ. ΠΠ΄Π΅ΡΠ°, Π£ΠΊΡΠ°ΠΈΠ½Π°Β Π Π΅Π·ΡΠΌΠ΅ΠΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΡΠΎΠ΄ΠΎ ΡΡΠΈΠ²Π°Π»ΠΎΠ³ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρ ΡΠΎΠ»Π΅ΠΉ ΠΊΠ°Π΄ΠΌΡΡ, ΡΡΡΡΡ, ΡΠ²ΠΈΠ½ΡΡ Π² Π΄ΠΎΠ·Ρ 1/50 Π²ΡΠ΄ DL50 Π½Π° Π½ΠΈΡΠΊΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΠΎ Π²Π°ΠΆΠ»ΠΈΠ²ΠΈΠΌ Π°ΡΠΏΠ΅ΠΊΡΠΎΠΌ ΡΡ
Π΄ΡΡ Ρ Π·ΠΌΡΠ½Π° ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΡΠ² Π°Π·ΠΎΡΠΈΡΡΠΎΠ³ΠΎ ΠΎΠ±ΠΌΡΠ½Ρ, ΡΠΊΠ° ΠΏΡΠΎΡΠ²Π»ΡΠ»Π°ΡΡ ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½ΠΈΠΌ Π²ΠΌΡΡΡΠΎΠΌ ΠΊΡΠ΅Π°ΡΠΈΠ½ΡΠ½Ρ, ΡΠ΅ΡΠΎΠ²ΠΈΠ½ΠΈ ΡΠ° ΡΠ΅ΡΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Π² ΡΠΈΡΠΎΠ²Π°ΡΡΡ ΠΊΡΠΎΠ²Ρ, Π° ΡΠ°ΠΊΠΎΠΆ Π²ΠΈΡΠΎΠΊΠΈΠΌ Π²ΠΌΡΡΡΠΎΠΌ Π±ΡΠ»ΠΊΡ Π² ΡΠ΅ΡΡ. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎΡ ΠΎΠ·Π½Π°ΠΊΠΎΡ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ Π½ΠΈΡΠΎΠΊ Ρ Π·Π½ΠΈΠΆΠ΅Π½Π½Ρ ΡΠ²ΠΈΠ΄ΠΊΠΎΡΡΡ ΠΊΠ»ΡΠ±ΠΎΡΠΊΠΎΠ²ΠΎΡ ΡΡΠ»ΡΡΡΠ°ΡΡΡ, ΡΠΊΠ° Π²ΠΈΠ·Π½Π°ΡΠ°Π»Π°ΡΡ ΠΏΡΠΈ Π΄ΡΡ Π²ΡΡΡ
ΡΡΡΠΎΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π½ΠΈΡ
Π½Π΅ΡΡΠΎΡΠΎΠΊΡΠΈΠΊΠ°Π½ΡΡΠ²: ΠΏΡΠΈ Π΄ΡΡ Cd β Π·Π½ΠΈΠΆΠ΅Π½Π½Ρ Π½Π° 23,6 %, ΠΏΡΠΈ Π΄ΡΡ Pb β Π½Π° 22,1 %, ΠΏΡΠΈ Π΄ΡΡ Hg β 28,9 %. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π΄ΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ Π²ΡΡΠ°Π½ΠΎΠ²ΠΈΡΠΈ Π½ΠΎΠ²Ρ ΡΠ°ΠΊΡΠΈ, ΡΠΎΠ΄ΠΎ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡ Π΄ΡΡ Π½Π΅ΠΎΡΠ³Π°Π½ΡΡΠ½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ Cd, Hg, Pb, ΡΠΊΡ ΠΏΠΎΠ»ΡΠ³Π°ΡΡΡ Ρ Π·Π΄Π°ΡΠ½ΠΎΡΡΡ ΠΌΠ΅ΡΠ°Π»ΡΠ² Π²ΠΈΠΊΠ»ΠΈΠΊΠ°ΡΠΈ ΡΠΈΡΠΎΠΏΠ°ΡΠΈΡΠ½Ρ Π΄ΡΡ Π½Π° ΠΎΠΊΡΠ΅ΠΌΡ ΠΊΠ»ΡΡΠΈΠ½ΠΈ ΡΡΡΡΠΊΡΡΡΠ½ΠΈΡ
Π΅Π»Π΅ΠΌΠ΅Π½ΡΡΠ² Π½Π΅ΡΡΠΎΠ½Ρ. ΠΡΠΎΠ²ΡΠ΄Π½ΠΈΠΌ ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠΎΠΌ ΡΠΎΠ·Π²ΠΈΡΠΊΡ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠ°Π»ΠΎΠ½Π΅ΡΡΠΎΠΏΠ°ΡΡΠΉ Ρ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ Π΅ΠΏΡΡΠ΅Π»ΡΡ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΈΡ
ΠΊΠ°Π½Π°Π»ΡΡΡΠ² Π½ΠΈΡΠΎΠΊ, ΡΠΊΠ΅ Π·ΡΠΌΠΎΠ²Π»Π΅Π½ΠΎ Π²ΠΈΠ±ΡΡΠΊΠΎΠ²ΠΈΠΌ ΠΏΠΎΡΡΡΠ΅Π½Π½ΡΠΌ ΠΊΠ»ΡΡΠΈΠ½Π½ΠΈΡ
ΠΌΠ΅ΠΌΠ±ΡΠ°Π½, ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠΉ Ρ Π»ΡΠ·ΠΎΡΠΎΠΌ Π΅ΠΏΡΡΠ΅Π»ΡΡ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΈΡ
ΠΊΠ°Π½Π°Π»ΡΡΡΠ² Π½Π΅ΡΡΠΎΠ½Ρ.ΠΠ»ΡΡΠΎΠ²Ρ ΡΠ»ΠΎΠ²Π°: Π²Π°ΠΆΠΊΡ ΠΌΠ΅ΡΠ°Π»ΠΈ, Π½ΠΈΡΠΊΠΈ, ΠΌΠ΅ΡΠ°Π»ΠΎΠ½Π΅ΡΡΠΎΠΏΠ°ΡΡΡ, ΠΊΡΠ΅Π°ΡΠΈΠ½ΡΠ½, ΡΠ΅ΡΠΎΠ²ΠΈΠ½Π°, Π±ΡΠ»ΠΎΠΊ, ΡΠ²ΠΈΠ΄ΠΊΡΡΡΡ ΠΊΠ»ΡΠ±ΠΎΡΠΊΠΎΠ²ΠΎΡ ΡΡΠ»ΡΡΡΠ°ΡΡΡ, Π³ΡΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½Π΅ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π½ΠΈΡΠΎΠΊ, ΠΊΠ°Π½Π°Π»ΡΡΠ΅Π²ΠΈΠΉ Π°ΠΏΠ°ΡΠ°Ρ, Π΅ΠΏΡΡΠ΅Π»ΡΠΎΡΠΈΡΠΈ.Β THE STUDY OF MORPHOFUNCTIONAL FEATURES OF THE DEVELOPMENT OF EXPERIMENTAL METALLONEPHROPATHYΒ A. I. Gozhenko, S. P. Lugovskoy, N. A. Samokhina Β Ukrainian Scientific and Research Institute of Transport Medicine, OdessaΒ SummaryEexperimental studies of prolonged exposure of cadmium salts, mercury, lead in the dose of from 1/50 DL50 on the kidney have shown that an important aspect of their actions is the change of indicators of nitrogen metabolism, which was manifested by increased creatinine, urea and uric acid in serum and high urine protein excretion. A characteristic feature of renal disease is the decline in glomerular filtration rate, which was defined when all three of the studied nephrotoxicants: under the Cd decrease by 23,6 %, under the action of Pb - 22,1 %, under the action of Hg β 28,9 %. Morphological studies revealed new facts concerning the morphological characteristics of toxic action of inorganic compounds of Cd, Hg, Pb, which lies in the ability of metals to cause cytopathic effect on individual cells of the structural elements of the nephron. The main mechanism for the development of experimental metallonephropathy is the damage to the epithelium of the proximal tubules of the kidneys, due to a selective disturbance of cellular membranes, mitochondria and lysosomes in the epithelium of the proximal tubules of the nephron.Key words: heavy metals, kidneys, metallonephropathy, creatinine, urea, protein, glomerular filtration rate, and histological examination of the kidneys, tubular apparatus, the epithelial cells.Β ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ ΠΠΠ Π€ΠΠ€Π£ΠΠΠ¦ΠΠΠΠΠΠ¬ΠΠ«Π₯ ΠΠ‘ΠΠΠΠΠΠΠ‘Π’ΠΠ Π ΠΠΠΠΠ’ΠΠ― ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’ΠΠΠ¬ΠΠ«Π₯ ΠΠΠ’ΠΠΠΠΠΠΠ€Π ΠΠΠΠ’ΠΠ Β Π. Π. ΠΠΎΠΆΠ΅Π½ΠΊΠΎ, Π‘. Π. ΠΡΠ³ΠΎΠ²ΡΠΊΠΎΠΉ, Π. Π. Π‘Π°ΠΌΠΎΡ
ΠΈΠ½Π°Β Π£ΠΊΡΠ°ΠΈΠ½ΡΠΊΠΈΠΉ ΠΠΠ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ°, Π³.ΠΠ΄Π΅ΡΡΠ°Β Π Π΅Π·ΡΠΌΠ΅ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΎΠ»Π΅ΠΉ ΠΊΠ°Π΄ΠΌΠΈΡ, ΡΡΡΡΠΈ, ΡΠ²ΠΈΠ½ΡΠ° Π² Π΄ΠΎΠ·Π΅ 1/50 DL50 Π½Π° ΠΏΠΎΡΠΊΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π²Π°ΠΆΠ½ΡΠΌ Π°ΡΠΏΠ΅ΠΊΡΠΎΠΌ ΠΈΡ
Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π°Π·ΠΎΡΠΈΡΡΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΡΠΎΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½Π°, ΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ ΠΈ ΠΌΠΎΡΠ΅Π²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΡΡΠΎΠΊΠΈΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π±Π΅Π»ΠΊΠ° Π² ΠΌΠΎΡΠ΅. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΏΠΎΡΠ΅ΠΊ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΠΊΠΎΡΠΎΡΡΠΈ ΠΊΠ»ΡΠ±ΠΎΡΠΊΠΎΠ²ΠΎΠΉ ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»Π°ΡΡ ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Π²ΡΠ΅Ρ
ΡΡΠ΅Ρ
ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
Π½Π΅ΡΡΠΎΡΠΎΠΊΡΠΈΠΊΠ°Π½ΡΠΎΠ²: ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Cd β ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π½Π° 23,6 %, ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Pb β Π½Π° 22,1 %, ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Hg β 28,9 %. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π½ΠΎΠ²ΡΠ΅ ΡΠ°ΠΊΡΡ, ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π΅ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Cd, Hg, Pb, ΠΊΠΎΡΠΎΡΡΠ΅ Π·Π°ΠΊΠ»ΡΡΠ°ΡΡΡΡ Π² ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² Π²ΡΠ·ΡΠ²Π°ΡΡ ΡΠΈΡΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΡΡΡΠΊΡΡΡΠ½ΡΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² Π½Π΅ΡΡΠΎΠ½Π°. ΠΠ΅Π΄ΡΡΠΈΠΌ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠ°Π»ΠΎΠ½Π΅ΡΡΠΎΠΏΠ°ΡΠΈΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΠΊΠ°Π½Π°Π»ΡΡΠ΅Π² ΠΏΠΎΡΠ΅ΠΊ, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ Π²ΡΠ±ΠΎΡΠΎΡΠ½ΡΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΌΠ΅ΠΌΠ±ΡΠ°Π½, ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠΉ ΠΈ Π»ΠΈΠ·ΠΎΡΠΎΠΌ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΠΊΠ°Π½Π°Π»ΡΡΠ΅Π² Π½Π΅ΡΡΠΎΠ½Π°.ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΡΡΠΆΠ΅Π»ΡΠ΅ ΠΌΠ΅ΡΠ°Π»Π»Ρ, ΠΏΠΎΡΠΊΠΈ, ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ½Π΅ΡΡΠΎΠΏΠ°ΡΠΈΠΈ, ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½, ΠΌΠΎΡΠ΅Π²ΠΈΠ½Π°, Π±Π΅Π»ΠΎΠΊ, ΡΠΊΠΎΡΠΎΡΡΡ ΠΊΠ»ΡΠ±ΠΎΡΠΊΠΎΠ²ΠΎΠΉ ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΠΈ, Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΡΠ΅ΠΊ, ΠΊΠ°Π½Π°Π»ΡΡΠ΅Π²ΡΠΉ Π°ΠΏΠΏΠ°ΡΠ°Ρ, ΡΠΏΠΈΡΠ΅Π»ΠΈΠΎΡΠΈΡΡ
Relationships between geomagnetic ΠΡ-indeΡ and EEG parameters in patients with dysfunction of the neuroendocrine-immune complex
Background. Recently, on the example of two cohort of patients, we found that disturbances of the geomagnetic field cause a significant immediate modulating effect on the level of immune parameters in the blood. The data available in the literature give grounds for assumptions about the direct effect of disturbances of the geomagnetic field on immunocytes, and indirectly, through immunotropic neurotransmitters and hormones. Our hypothesis is as follows. Disturbances of the geomagnetic field are perceived by acupuncture points (APs). The information obtained is transmitted to neurons and endocrinocytes, the mediators of which, in turn, affect immunocytes. The purpose of this study is to test this hypothesis.
Methods. The object of observation were 21 men (24-63 y) and 20 women (30-72 y) with neuroendocrine-immune complex dysfunction. Each patient was tested twice with an interval of 4 days. We recorded the ongoing electroencephalogram (EEG). Retrospectively we recorded the geomagnetic Ap-Index on the day of testing and during the previous 7 days, using resource https://www.spaceweatherlive.com/.
Results. The canonical correlation between Ap-indices for 7 days before and on the day of testing, and EEG parameters is 0,886; immunity parameters is 0,921. In turn, the immune parameters are closely related to the EEG parameters (R=0,944).
Conclusion. Disturbances of the geomagnetic field (Ap-index) causes a significant immediate modulating effect on the parameters of immunity as well as EEG, apparently through acupuncture points as polymodal receptors of the ecoceptive sensitivity system
Morpho-functional basis of endothelial dysfunction in diabetes mellitus
The diabetes mellitus (DM) inevitably progresses and leads to complications, among which the main place is occupied by micro- and macroangiopathies. The presence of endothelial damage in DM can be established even before macroscopically significant damage to the vessel. At the same time, there is no summary ED characteristic for diabetes. The aim of the study is to make a comprehensive evaluation of ED in DM -1 and DM-2 types.Materials and methods of research. 60 persons, including 53 DM type 1 and type 2, with a severe course (state of decompensation) participated in the present study. We used the method of estimating ED by the number of circulating desquamation endothelial cells (CECs) at the stages of decomposition with simultaneous determination of NO2- and NO3- metabolites of nitric oxide.Results and discussion. In patients with diabetes, the level of CECs increased in 3-5 times and ranged from 1800 to 11,200 cells / ml. The average amount of CECs in patients with diabetes was 3358.5 Β± 366.3 cells / ml.Conclusions: Endothelium is involved in the pathological process at DM. This is evidenced by a significant increase in CECs in the blood plasma. The use of this method allows to detect ED before clinically considerable vascular impairment and reflects the severity of the course and duration of DM
Information sphere: prospects of development and social risks
In article the increasing relevance and the information importance in spheres of the modern habitat of the person from a position of a scientific discourse, public attention and dialogue of the international community is considere
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΎΡΠΌΠΎΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ ΡΠ°Ρ Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ 1 ΡΠΈΠΏΠ° = Features of the renal osmoregulatory function in patients with type 1 diabetes
Kuznetsova E. S., Kuznetsova E. N., Shuhtin V. V., Gozhenko A. I. ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΎΡΠΌΠΎΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΠ°Ρ
Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ 1 ΡΠΈΠΏΠ° = Features of the renal osmoregulatory function in patients with type 1 diabetes. Journal of Education, Health and Sport. 2015;5(8):64-72. ISSN 2391-8306. DOI 10.5281/zenodo.23452http://dx.doi.org/10.5281/zenodo.23452https://pbn.nauka.gov.pl/works/603458POL-index https://pbn.nauka.gov.pl/polindex/browse/article/article-723295be-1b7a-4fb7-977a-b926e021635bhttp://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%288%29%3A64-72Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011β2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archiveΒ Deklaracja.Specyfika i zawartoΕΔ merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacjΔ
MNiSW z dnia 2 czerwca 2014 r., ΕΌe w roku 2014 nie bΔdzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktΓ³w co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).Β© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.06.2015. Revised 15.07.2015. Accepted: 25.07.2015.Β Π£ΠΠ 616.43;616-008.9Β ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΎΡΠΌΠΎΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΠ°Ρ
Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ 1 ΡΠΈΠΏΠ°Features of the renal osmoregulatory function in patients with type 1 diabetesΒ Π. Π‘. ΠΡΠ·Π½Π΅ΡΠΎΠ²Π°, Π. Π. ΠΡΠ·Π½Π΅ΡΠΎΠ²Π°, Π. Π. Π¨ΡΡ
ΡΠΈΠ½, Π. Π. ΠΠΎΠΆΠ΅Π½ΠΊΠΎ E. S. Kuznetsova, E. N. Kuznetsova, V. V. Shuhtin, A. I. GozhenkoΒ Π£ΠΊΡΠ°ΠΈΠ½ΡΠΊΠΈΠΉ Π½Π°ΡΡΠ½ΠΎ β ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΠΉ ΠΈΠ½ΡΡΠΈΡΡΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° ΠΠ Π£ΠΊΡΠ°ΠΈΠ½Ρ, ΠΠ΄Π΅ΡΡΠ°Ukrainian Scientific Research Institute of Transport Medicine MH Ukraine, OdessaΒ AbstractΒ In the context of water - salt load with 0,5% NaCl the osmoregulatory renal function state in 28 patients with type 1 diabetes.It is shown that as the GFR declines to 60 ml \ min the diuresis and % of the discharged liquid increases from 176 ml and 46.1% to 213 ml and 59.5%, while the relative density of urine and osmolality, conversely, decreases. A direct relationship was observed between diuresis and excretion of osmotically active substances (correlation coefficient 0.76 - 0.91), between excretion of osmotically active substances and % of the discharged liquid (0.8 - 0.91), between the relative density and urine osmolality (0.85 - 0.9), between excretion of osmotically active substances (OAS) and glycosuria: thus, maximum excretion of OAS of 224.1 and 345 mOsmol \ hour was combined with glycosuria of 210 and 220 mmol/l.In most of cases (96.4%), glomerular filtration rate averagely increased 2-fold in patients with diabetes 1 type under water - salt stress, rising from 36.9 to 322.5 ml \ min, and renal functional reserve ranged from 36.9 to 439.6%. However, a direct relationship between the RFR and urine osmolality, as well as with an osmotically active substances excretion, was not found.Thus, in type 1 diabetes osmoregulatory renal disorders depend both on the reduction in GFR to 60 ml \ min Β and on changes in the functional capacity of nephron`s tubules.Β Β Key words: diabetes mellitus type 1, osmoregulatory function state of kidneys, water- salt load, excretion of osmotically active substances, renal functional reserve.Β Π Π΅Π·ΡΠΌΠ΅Β Π ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π²ΠΎΠ΄Π½ΠΎ- ΡΠΎΠ»Π΅Π²ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ Ρ 0,5 % NaCl ΠΈΠ·ΡΡΠ΅Π½ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΎΡΠΌΠΎΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ Ρ 28 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΠ°Ρ
Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ 1 ΡΠΈΠΏΠ°.ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΠΎ ΠΌΠ΅ΡΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π‘ΠΠ€ Π΄ΠΎ 60 ΠΌΠ»\ΠΌΠΈΠ½, Π΄ΠΈΡΡΠ΅Π· ΠΈ % Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π»ΠΈ Ρ 176 ΠΌΠ»Β ΠΈ 46,1 % Π΄ΠΎ 213 ΠΌΠ» ΠΈ 59,5 % , ΠΏΡΠΈ ΡΡΠΎΠΌΒ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΌΠΎΡΠΈ ΠΈ ΠΎΡΠΌΠΎΠ»ΡΠ»ΡΠ½ΠΎΡΡΡ, Π½Π°ΠΎΠ±ΠΎΡΠΎΡ, ΡΠ½ΠΈΠΆΠ°Π»ΠΈΡΡ. ΠΡΡΠΌΠ°Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ ΠΌΠ΅ΠΆΠ΄Ρ Π΄ΠΈΡΡΠ΅Π·ΠΎΠΌ ΠΈ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠ΅ΠΉ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² (ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ 0,76 - 0.91), ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠ΅ΠΉ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΈ % Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ (0.8 - 0,91), ΠΌΠ΅ΠΆΠ΄ΡΒ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡΡ ΠΈ ΠΎΡΠΌΠΎΠ»ΡΠ»ΡΠ½ΠΎΡΡΡΡ ΠΌΠΎΡΠΈ (0.85 Π΄ΠΎ 0,9) ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠ΅ΠΉ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΈ Π³Π»ΡΠΊΠΎΠ·ΡΡΠΈΠ΅ΠΉ: ΡΠ°ΠΊ, ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ ΡΠΊΡΠΊΡΠ΅ΡΠΈΡ ΠΠΠ 224,1 ΠΈ 345 ΠΌΠΎΡΠΌΠΎΠ»Ρ\ΡΠ°Ρ Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ ΠΏΡΠΈ Π³Π»ΡΠΊΠΎΠ·ΡΡΠΈΠΈ 210 ΠΈ 220 ΠΌΠΌΠΎΠ»Ρ\Π».Π Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π² (96,4 %) ΡΠΊΠΎΡΠΎΡΡΡ ΠΊΠ»ΡΠ±ΠΎΡΠΊΠΎΠ²ΠΎΠΉ ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π‘Π 1ΡΠΈΠΏΠ° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π²ΠΎΠ΄Π½ΠΎ-ΡΠΎΠ»Π΅Π²ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π»Π°, Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ Π² 2 ΡΠ°Π·Π°, ΠΏΠΎΠ²ΡΡΠ°ΡΡΡ ΠΎΡ 36,9 Π΄ΠΎ 322,5 ΠΌΠ»\ΠΌΠΈΠ½, Π° ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΏΠΎΡΠ΅ΡΠ½ΡΠΉ ΡΠ΅Π·Π΅ΡΠ² Π½Π°Ρ
ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
ΠΎΡ 36,9 Π΄ΠΎ 439,6 %. ΠΠ΄Π½Π°ΠΊΠΎ ΠΏΡΡΠΌΠΎΠΉ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄ΡΒ Π²Π΅Π»ΠΈΡΠΈΠ½ΠΎΠΉ Π€ΠΠ ΠΈ ΠΎΡΠΌΠΎΠ»ΡΠ»ΡΠ½ΠΎΡΡΡΡ ΠΌΠΎΡΠΈ, ΡΠ°ΠΊ ΠΆΠ΅ ΠΊΠ°ΠΊ ΠΈ Ρ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠ΅ΠΉ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² Π½Π΅ Π±ΡΠ»ΠΎ.Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΏΡΠΈ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠ΅ 1 ΡΠΈΠΏΠ° ΠΏΠΎΡΠ²Π»ΡΡΡΡΡ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΎΡΠΌΠΎΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ, ΠΊΠΎΡΠΎΡΡΠ΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡ ΠΊΠ°ΠΊ ΠΏΠΎ ΠΌΠ΅ΡΠ΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ Π‘ΠΠ€ Π΄ΠΎ 60 ΠΌΠ»\ΠΌΠΈΠ½, ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΊΠ°Π½Π°Π»ΡΡΠ΅Π² Π½Π΅ΡΡΠΎΠ½ΠΎΠ².Β ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΡΠ°Ρ
Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ 1 ΡΠΈΠΏ, ΠΎΡΠΌΠΎΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠ°Ρ ΡΡΠ½ΠΊΡΠΈΡ ΠΏΠΎΡΠ΅ΠΊ, Π²ΠΎΠ΄Π½ΠΎ-ΡΠΎΠ»Π΅Π²Π°Ρ ΠΏΡΠΎΠ±Π°, ΡΠΊΡΡΠ΅ΡΠΈΡ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ², ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΏΠΎΡΠ΅ΡΠ½ΡΠΉ ΡΠ΅Π·Π΅ΡΠ²
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