A Software Framework for Automated Negotiation

If agents are to negotiate automatically with one another they must share a negotiation mechanism, specifying what possible actions each party can take at any given time, when negotiation terminates, and what is the structure of the resulting agreements. Current standardization activities such as FIPA [2] and WS-Agreement [3] represent this as a negotiation protocol specifying the flow of messages. However, they omit other aspects of the rules of negotiation (such as obliging a participant to improve on a previous offer), requiring these to be represented implicitly in an agent’s design, potentially resulting incompatibility, maintenance and re-usability problems. In this chapter, we propose an alternative approach, allowing all of a mechanism to be formal and explicit. We present (i) a taxonomy of declarative rules which can be used to capture a wide variety of negotiation mechanisms in a principled and well-structured way; (ii) a simple interaction protocol, which is able to support any mechanism which can be captured using the declarative rules; (iii) a software framework for negotiation that allows agents to effectively participate in negotiations defined using our rule taxonomy and protocol and (iv) a language for expressing aspects of the negotiation based on OWL-Lite [4]. We provide examples of some of the mechanisms that the framework can support

Compositional Specification of a Reusable Co-operative Agent Model

Item does not contain fulltextIn this paper one of the informally described models of agent co-operation (Jennings, 1995) has been used to develop and formally specify a generic model of a co-operative agent (GCAM). The compositional development method for multi-agent systems DESIRE supported the principled design of this model of cooperation. To illustrate reusability of the generic model, two application domains have been addressed: collaborative engineering design, and Call Center support

Anticancer activities of novel Mannich bases against prostate cancer cells

demirci, serpil/0000-0002-6579-4273WOS: 000489305700012This study was designed to synthesize hybridizing molecules starting from compound of 6-(4-phenyl-piperazin-1-yl)pyridine-3-ylamine by enhancing its biological activity with other heterocycles and to determine anticancer activity of the resulting compounds. To this end, 6-(4-phenylpiperazin-1-yl)pyridin-3-ylamine (4) was used as the leading compound, which is known to exert anticancer activities. The synthesis of the leading compound was carried out using 1-(5-nitropyridin-2-yl)-4-phenylpiperazine (3) which was obtained by a novel method with the reaction of N-phenylpiperazine (2) and 2-chloro-5-nitropyridine. 6-(4-phenylpiperazin-1-yl)pyridin-3-ylamine (4) was converted to compound 5, an active intermediate compound, by substitution of one of the amine hydrogens with ethyl bromoacetate. The resulting ester product (5) followed by the hydrazidation (6) was added arylisocyanate to obtain the active intermediate (8). Then, by a series of substitution through cyclization and condensation reactions, thiazolidinone (9), 1,3,4-oxadiazole (7), and 1,2,4-triazole (10) were synthesized. Novel Mannich bases (11a-11f and 12a-12f) were obtained using oxazole (7) and triazole (10) hetero rings with primer or secondary amine compounds. The characterization of the compounds was completed using FT IR, H-1-NMR, C-13-NMR, HRMS spectroscopic methods and elemental analysis technique. The chemicals, then, were tested for their anticancer activities against prostate cancer cell lines PC3 [ATCC, CRL-1435], LNCaP [ATCC, CRL-1740], and DU145 [ATCC, HTB-81]. The results revealed that the Mannich bases exhibited moderate cytotoxic activity against cancer cells tested.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [116Z932]The support provided by Scientific and Technological Research Council of Turkey (TUBITAK, Project no: 116Z932) is gratefully acknowledged. We thank to Selami Demirci for his help in paper editing