269 research outputs found
Magnetic domain structure and dynamics in interacting ferromagnetic stacks with perpendicular anisotropy
The time and field dependence of the magnetic domain structure at
magnetization reversal were investigated by Kerr microscopy in interacting
ferromagnetic Co/Pt multilayers with perpendicular anisotropy. Large local
inhomogeneous magnetostatic fields favor mirroring domain structures and domain
decoration by rings of opposite magnetization. The long range nature of these
magnetostatic interactions gives rise to ultra-slow dynamics even in zero
applied field, i.e. it affects the long time domain stability. Due to this
additionnal interaction field, the magnetization reversal under short magnetic
field pulses differs markedly from the well-known slow dynamic behavior.
Namely, in high field, the magnetization of the coupled harder layer has been
observed to reverse more rapidly by domain wall motion than the softer layer
alone.Comment: 42 pages including 17 figures. submitted to JA
Simulation of neutrino and charged particle production and propagation in the atmosphere
A precise evaluation of the secondary particle production and propagation in
the atmosphere is very important for the atmospheric neutrino oscillation
studies. The issue is addressed with the extension of a previously developed
full 3-Dimensional Monte-Carlo simulation of particle generation and transport
in the atmosphere, to compute the flux of secondary protons, muons and
neutrinos. Recent balloon borne experiments have performed a set of accurate
flux measurements for different particle species at different altitudes in the
atmosphere, which can be used to test the calculations for the atmospheric
neutrino production, and constrain the underlying hadronic models. The
simulation results are reported and compared with the latest flux measurements.
It is shown that the level of precision reached by these experiments could be
used to constrain the nuclear models used in the simulation. The implication of
these results for the atmospheric neutrino flux calculation are discussed.Comment: 11 pages, 9 figure
The metabolic cost of lowering blood pressure with hydrochlorothiazide
Abstract
Background
The landmark Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) placed a new spotlight on thiazide diuretics as the first-line therapy for hypertension. This is concerning as thiazide-diuretics may contribute to comorbidities associated with the current epidemic of obesity. Previous randomized clinical trials have linked thiazide diuretic treatment to insulin resistance, metabolic syndrome, and increased incidence of type 2 diabetes.
Methods
This proof of concept, longitudinal, randomized, double–blind study evaluated the effects of the angiotensin II receptor blocker Valsartan and the specific thiazide diuretic Hydrochlorothiazide (HCTZ) on hepatic triglyceride level (primary outcome), as well as triglyceride levels within other organs including the heart, skeletal muscle, and pancreas. Additionally, we evaluated whether myocardial function, insulin sensitivity, and insulin secretion were affected by these treatments.
Results
Hepatic TG levels increased by 57% post HCTZ treatment: ∆hTG HCTZ = 4.12% and remained unchanged post Valsartan treatment: ∆hTG V = 0.06%. The elevation of hepatic TG levels after HCTZ treatment was additionally accompanied by a reduction in insulin sensitivity: ∆SI HCTZ = -1.14. Treatment with Valsartan resulted in improved insulin sensitivity: ∆SI V = 1.24. Treatment-induced changes in hepatic TG levels and insulin sensitivity were statistically significant between groups (phTG = 0.0098 and pSI = 0.0345 respectively). Disposition index, DI, remained unchanged after HCTZ treatment: ∆DI HCTZ = -141 but it was increased by a factor of 2 after treatment with Valsartan: ∆DI V =1018). However, the change between groups was not statistically significant. Both therapies did not modify abdominal visceral and subcutaneous fat mass as well as myocardial structure and function. Additionally, myocardial, pancreatic, and skeletal muscle triglyceride deposits remained unchanged in both therapeutic arms.
Conclusions
Our findings are two-fold and relate to hepatic steatosis and insulin sensitivity. HCTZ treatment worsened hepatic steatosis measured as hepatic triglyceride content and reduced insulin sensitivity. Valsartan treatment did not affect hepatic triglyceride levels and improved insulin sensitivity. The results of this study reinforce the message that in patients at risk for type 2 diabetes it is particularly important to choose an antihypertensive regimen that lowers blood pressure without exacerbating patient’s metabolic profile
Meaurement of Cosmic Ray elemental composition from the CAKE balloon experiment
CAKE (Cosmic Abundances below Knee Energies) was a prototype balloon
experiment for the determination of the charge spectra and of abundances of the
primary cosmic-rays (CR) with Z10. It was a passive instrument made of
layers of CR39 and Lexan nuclear track detectors; it had a geometric acceptance
of 0.7 msr for Fe nuclei. Here, the scanning and analysis strategies,
the algorithms used for the off-line filtering and for the tracking in
automated mode of the primary cosmic rays are presented, together with the
resulting CR charge distribution and their abundances.Comment: 5 pages, 8 figure
Energy spectra of cosmic-ray nuclei at high energies
We present new measurements of the energy spectra of cosmic-ray (CR) nuclei
from the second flight of the balloon-borne experiment Cosmic Ray Energetics
And Mass (CREAM). The instrument included different particle detectors to
provide redundant charge identification and measure the energy of CRs up to
several hundred TeV. The measured individual energy spectra of C, O, Ne, Mg,
Si, and Fe are presented up to eV. The spectral shape looks
nearly the same for these primary elements and it can be fitted to an power law in energy. Moreover, a new measurement of the absolute
intensity of nitrogen in the 100-800 GeV/ energy range with smaller errors
than previous observations, clearly indicates a hardening of the spectrum at
high energy. The relative abundance of N/O at the top of the atmosphere is
measured to be (stat.)(sys.) at 800
GeV/, in good agreement with a recent result from the first CREAM flight.Comment: 32 pages, 10 figures. Accepted for publication in Astrophysical
Journa
Turbulent diffusion and drift in galactic magnetic fields and the explanation of the knee in the cosmic ray spectrum
We reconsider the scenario in which the knee in the cosmic ray spectrum is
explained as due to a change in the escape mechanism of cosmic rays from the
Galaxy from one dominated by transverse diffusion to one dominated by drifts.
We solve the diffusion equations adopting realistic galactic field models and
using diffusion coefficients appropriate for strong turbulence (with a
Kolmogorov spectrum of fluctuations) and consistent with the assumed magnetic
fields. We show that properly taking into account these effects leads to a
natural explanation of the knee in the spectrum, and a transition towards a
heavier composition above the knee is predicted.Comment: 17 pp., 6 figures; revised version with minor changes. To appear in
JHE
Cosmic-Ray Proton and Helium Spectra from the First CREAM Flight
Cosmic-ray proton and helium spectra have been measured with the
balloon-borne Cosmic Ray Energetics And Mass experiment flown for 42 days in
Antarctica in the 2004-2005 austral summer season. High-energy cosmic-ray data
were collected at an average altitude of ~38.5 km with an average atmospheric
overburden of ~3.9 g cm. Individual elements are clearly separated with
a charge resolution of ~0.15 e (in charge units) and ~0.2 e for protons and
helium nuclei, respectively. The measured spectra at the top of the atmosphere
are represented by power laws with a spectral index of -2.66 0.02 for
protons from 2.5 TeV to 250 TeV and -2.58 0.02 for helium nuclei from 630
GeV/nucleon to 63 TeV/nucleon. They are harder than previous measurements at a
few tens of GeV/nucleon. The helium flux is higher than that expected from the
extrapolation of the power law fitted to the lower-energy data. The relative
abundance of protons to helium nuclei is 9.1 0.5 for the range from 2.5
TeV/nucleon to 63 TeV/nucleon. This ratio is considerably smaller than the
previous measurements at a few tens of GeV/nucleon.Comment: 20 pages, 4 figure
Measurement of the gluon PDF at small x with neutrino telescopes
We analyze the possibility that neutrino telescopes may provide an
experimental determination of the slope lambda of the gluon distribution in the
proton at momentum fractions x smaller than the accelerator reach. The method
is based on a linear relation between lambda and the spectral index (slope) of
the down-going atmospheric muon flux above 100 TeV, for which there is no
background. Considering the uncertainties in the charm production cross section
and in the cosmic ray composition, we estimate the error on the measurement of
lambda through this method, excluding the experimental error of the telescopes,
to be ~ +/- 0.2Comment: 16 pages with 16 figures - new version, comments added, same results
and figure
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