6,253 research outputs found
Feasibility Of OneâDedicatedâLane Bus Rapid Transit âLightâRail Systems And Their Expansion To TwoâDedicatedâLane Systems: A Focus On Geometric Configuration And Performance Planning, MTI Report 08-01
This report consists primarily of two parts, the first on feasibility and the next on space minimization. In the section on feasibility, we propose the concept of a Bus Rapid Transit (BRT) or lightârail system that effectively requires only one dedicated but reversible lane throughout the system to support two-way traffic in the median of a busy commute corridor with regular provision of leftâturn lanes. Based on key ideas proposed in that section, the section on space minimization first addresses how to implement a twoâdedicatedâlane BRT or lightârail system with minimum rightâofâway width and then proposes ways to expand a oneâdedicatedâlane system to two dedicated lanes. In a oneâdedicatedâlane system, traffic crossing is accommodated on the otherwise unused or underused median space resulting from provision of the leftâturn lanes. Although not necessary, some leftâturn lanes can be sacrificed for bus stops. Conceptual design options and geometric configuration sketches for the bus stop and crossing space are provided in the section on feasibility, which also discusses system performance in terms of travel speed, headway of operations, distance between two neighboring crossing spaces, and number of crossing spaces. To ensure practicality, we study implementation of such a system on an existing corridor. Such a system is also useful as an intermediate step toward a twoâdedicatedâlane system because of its potential for facilitating transitâoriented development. In typical existing or planned BRT or lightârail systems implemented with two dedicated traffic lanes, a space equivalent to four traffic lanes is dedicated for a bus stop. In the section on space minimization, we propose implementations requiring only three lanes at a bus stop, based on two key ideas proposed for a oneâdedicatedâlane system. That section also discusses ways to expand a oneâdedicatedâlane system to its corresponding twoâdedicatedâlane system
Effects of noise suppression and envelope dynamic range compression on the intelligibility of vocoded sentences for a tonal language
Vocoder simulation studies have suggested that the carrier signal type employed affects the intelligibility of vocoded speech. The present work further assessed how carrier signal type interacts with additional signal processing, namely, single-channel noise suppression and envelope dynamic range compression, in determining the intelligibility of vocoder simulations. In Experiment 1, Mandarin sentences that had been corrupted by speech spectrum-shaped noise (SSN) or two-talker babble (2TB) were processed by one of four single-channel noise-suppression algorithms before undergoing tone-vocoded (TV) or noise-vocoded (NV) processing. In Experiment 2, dynamic ranges of multiband envelope waveforms were compressed by scaling of the mean-removed envelope waveforms with a compression factor before undergoing TV or NV processing. TV Mandarin sentences yielded higher intelligibility scores with normal-hearing (NH) listeners than did noise-vocoded sentences. The intelligibility advantage of noise-suppressed vocoded speech depended on the masker type (SSN vs 2TB). NV speech was more negatively influenced by envelope dynamic range compression than was TV speech. These findings suggest that an interactional effect exists between the carrier signal type employed in the vocoding process and envelope distortion caused by signal processing
A Cortical Region Consisting Entirely of Face-Selective Cells
Face perception is a skill crucial to primates. In both humans and macaque monkeys, functional magnetic resonance imaging (fMRI) reveals a system of cortical regions that show increased blood flow when the subject views images of faces, compared with images of objects. However, the stimulus selectivity of single neurons within these fMRI-identified regions has not been studied. We used fMRI to identify and target the largest face-selective region in two macaques for single-unit recording. Almost all (97%) of the visually responsive neurons in this region were strongly face selective, indicating that a dedicated cortical area exists to support face processing in the macaque
Generation of energetic He atom beams by a pulsed positive corona discharge
Time-of-flight measurements were made of neutral helium atom beams extracted from a repetitive, pulsed, positive-point corona discharge. Two strong neutral peaks, one fast and one slow, were observed, accompanied by a prompt photon peak and a fast ion peak. All peaks were correlated with the pulsing of the discharge. The two types of atoms appear to be formed by different mechanisms at different stages of the corona discharge. The fast atoms had energies of 190 eV and were formed at the onset of the pulsing, approximately 0.7 ”s before the maximum of the photon peak. The slow peak, composed of electronically metastable He atoms, originated 30â50 ”s after the photon pulse, and possessed a nearly thermal velocity distribution. The velocity distribution was typical of an undisturbed supersonic expansion with a stagnation temperature of 131 K and a speed ratio of 3.6. Peak intensities and velocities were measured as a function of source voltage, stagnation pressure, and skimmer voltage
A nonlinear Schr\"odinger equation for water waves on finite depth with constant vorticity
A nonlinear Schr\"odinger equation for the envelope of two dimensional
surface water waves on finite depth with non zero constant vorticity is
derived, and the influence of this constant vorticity on the well known
stability properties of weakly nonlinear wave packets is studied. It is
demonstrated that vorticity modifies significantly the modulational instability
properties of weakly nonlinear plane waves, namely the growth rate and
bandwidth. At third order we have shown the importance of the coupling between
the mean flow induced by the modulation and the vorticity. Furthermore, it is
shown that these plane wave solutions may be linearly stable to modulational
instability for an opposite shear current independently of the dimensionless
parameter kh, where k and h are the carrier wavenumber and depth respectively
THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis
THR0921 is a novel peroxisome proliferator-activated receptor gamma (PPARÎł) agonist with potent anti-diabetic properties. Because of the proposed role of PPARÎł in inflammation, we investigated the potential of orally active THR0921 to inhibit the pathogenesis of collagen-induced arthritis (CIA). CIA was induced in DBA/1J mice by the injection of bovine type II collagen in complete Freund's adjuvant on days 0 and 21. Mice were treated with THR0921 (50 mg/kg/day) starting on the day of the booster injection and throughout the remaining study period. Both clinical disease activity scores as well as histological scores of joint destruction were significantly reduced in mice treated with THR0921 compared to untreated mice. Proliferation of isolated spleen cells, as well as circulating levels of IgG antibody to type II collagen, was decreased by THR0921. Moreover, spleen cell production of IFN-Îł, tumor necrosis factor (TNF)-α and IL-1ÎČ in response to exposure to lipopolysaccharide or type II collagen was reduced by in vivo treatment with THR0921. Steady state mRNA levels of TNF-α, IL-1ÎČ, monocyte chemotactic protein-1 and receptor activator of nuclear factor ÎșB ligand (RANKL) in isolated joints were all decreased in mice treated with THR0921. Finally, THR0921 inhibited osteoclast differentiation of bone marrow-derived cells stimulated with macrophage colony-stimulating factor and RANKL. In conclusion, THR0921 attenuates collagen-induced arthritis in part by reducing the immune response. As such, PPARÎł may be an important therapeutic target for rheumatoid arthritis
Modern role for clopidogrel in management of atrial fibrillation and stroke reduction
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The prevalence of AF increases sharply in old age (prevalence approximately 10% among persons 80 years of age and older). The expected risk for ischemic stroke is increased five-fold by the presence of AF, primarily as a result of cardiogenic embolism. Multiple large-scale, randomized trials have been completed or are still underway to find optimal, efficacious, and relatively safe ways to reduce the risk of ischemic stroke and other systemic thromboembolic events related to AF. Antithrombotic strategies are accompanied by serious bleeding complications that threaten patients in need of medical stroke prevention. Treatment regimens for preventing thromboembolism in AF patients range from vitamin K antagonists such as warfarin or coumadins, antiplatelet drugs like aspirin or clopidogrel, to newly developed orally available antithrombotics like the direct thrombin inhibitor dabigatran, or the Factor Xa-inhibitor rivaroxaban. The available anticoagulant and antiplatelet drugs have different advantages and disadvantages. This review attempts to delineate the specific role of clopidogrel in patients with AF and at risk of stroke, taking into consideration new and ongoing trials in this important field of medical practice
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