1,809 research outputs found
Hiroshima on Peace Education and Problems with U.S.-Centric Historical Narratives in a World Without Survivors
As time passes, the number of survivors from major world tragedies like the nuclear bombing of Hiroshima and Nagasaki grows fewer and fewer. These survivors are a powerful resource for educating students of all ages about the importance of world peace. Drawing on the writing of Richard Moody and Frans Doppen, as well as Paul Ham, and Herbert Feis respectively, I outline the important role of hibakusha, or a-bomb survivors, in peace education at the secondary and collegiate levels. I explain how personalized survivor testimony provides an alternative and highly effective and necessary counterweight to teaching solely a U.S.-centric historical narrative with regards to the end of World War II
Detection and measurement of paracaspase MALT1 activity.
The paracaspase MALT1 is a Cys-dependent, Arg-specific protease that plays an essential role in the activation and proliferation of lymphocytes during the immune response. Oncogenic activation of MALT1 is associated with the development of specific forms of B-cell lymphomas. Through specific cleavage of its substrates, MALT1 controls various aspects of lymphocyte activation, including the activation of transcriptional pathways, the stabilization of mRNAs, and an increase in cellular adhesion. In lymphocytes, the activity of MALT1 is tightly controlled by its inducible monoubiquitination, which promotes the dimerization of MALT1. Here, we describe both in vitro and in vivo assays that have been developed to assess MALT1 activity
Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.
The paracaspase MALT1 is an Arg-specific protease that cleaves multiple substrates to promote lymphocyte proliferation and survival. The catalytic activity of MALT1 is normally tightly regulated by antigen receptor triggering, which promotes MALT1 activation by its inducible monoubiquitination-dependent dimerization. Constitutive MALT1 activity is a hallmark of specific subsets of B-cell lymphomas, which are characterized by chromosomal translocations or point mutations that activate MALT1 or its upstream regulators. Recent findings suggest that such lymphomas may be sensitive to treatment with MALT1 inhibitors. Here we review recent progress in the understanding of MALT1 function and regulation, and the development of small molecule MALT1 inhibitors for therapeutic applications
Procrustes problem for the inverse eigenvalue problem of normal (skew) -Hamiltonian matrices and normal -symplectic matrices
A square complex matrix is called (skew) -Hamiltonian if is
(skew) hermitian where is a real normal matrix such that , where
is the identity matrix. In this paper, we solve the Procrustes problem to
find normal (skew) -Hamiltonian solutions for the inverse eigenvalue
problem. In addition, a similar problem is investigated for normal
-symplectic matrices.Comment: 25 page
Effect of Neuro-Linguistic Programming (NLP) on Anxiety: A Systematic Literature Review
Anxiety is a feeling of helplessness, and worry about things that are not clear, as well as a comprehensive feeling that something bad is going to happen. Anxiety is experienced subjectively and communicated interpersonally, at the same time feelings of anxiety are a necessary survival instinct. The Neuro-Linguistic Programming (NLP) is a communicative approach employs a positive view of anxiety and how it can help shape life changes, and that is the topic of this article. This research method uses a Systematic Literature Review, investigating Garuda, Pubmed, ScienceDirect, and Proquest, using boolean for keyword neurolinguistics programming (NLP) and anxiety. The inclusion criteria used were Indonesian and English language articles written within the last 5 years (from 2015 until 2020). The exclusion criteria used by the article were abstract writing style, inaccessible, or lacking national accreditation. Articles were tested with Critical Appraisal Tools. The studies indicate that good communication using NLP can help reduce anxiety and can promote changes in a person’s behavior patterns. There are several NLP techniques including sensory acuity, reframing, anchoring, rapport, and pacing, and leading. NLP can improve knowledge, skills and attitudes, communication skills, self-management, mental health, reduce work stress, and self-efficacy.
Keywords: Anxiety, Neuro-Linguistic Programming, NL
A model of non-perturbative gluon emission in an initial state parton shower
We consider a model of transverse momentum production in which
non-perturbative smearing takes place throughout the perturbative evolution, by
a simple modification to an initial state parton shower algorithm. Using this
as the important non-perturbative ingredient, we get a good fit to data over a
wide range of energy. Combining it with the non-perturbative masses and cutoffs
that are a feature of conventional parton showers also leads to a reasonable
fit. We discuss the extrapolation to the LHC.Comment: 14 pages, 6 figures; version accepted by JHE
Control strategy and performance of a small-size thermally integrated Carnot battery based on a Rankine cycle and combined with district heating
To encourage decarbonization and promote a widespread penetration of renewable energy sources in all energy sectors, the development of efficient energy storage systems is essential. Interesting grid-scale electricity storage technologies are the Carnot batteries, whose working principle is based on storing electricity in the form of thermal energy. The charging phase is performed through a heat pump cycle, and the discharging phase is conducted through a heat engine. Since both thermal and electric energy flows are involved, Carnot batteries can be adopted to provide more flexibility in heat and power energy systems. To this aim, efficient scheduling strategies are necessary to manage different energy flows. In this context, this work presents a detailed rule-based control strategy to schedule the synergetic work of a 10-kWe reversible heat pump/organic Rankine cycle Carnot battery integrated to a district heating substation and a photovoltaic power plant, to satisfy a local user's thermal and electric demand. The coupling of a Carnot battery with a district heating substation allows for shaving the thermal demand peaks through the thermal energy stored in the Carnot battery storage, allowing for a downsizing of the district heating substation, with a considerable reduction of the investment costs. Due to the multiplicity of the involved energy flows and the numerous modes of operation, a scheduling logic for the Carnot battery has been developed, to minimize the system operating costs, depending on the boundary conditions. To investigate the influence of the main system design parameters, a detailed and accurate model of the Carnot battery is adopted. Two variants of the reference system, with different heat pump cold source arrangements, are investigated. In the first case, the heat pump absorbs thermal energy from free waste heat. In the second case, the heat pump cold source is the return branch of the district heating substation. The simulation results show that, in the first case, the Carnot battery allows the downsizing of the district heating substation by 47 %, resulting in an annual gain of more than 5000 €. About 70 % of the economic benefit is due to the possibility of reducing the power size of the district heating substation, which can be from 300 to more than 500 kW. The payback period is estimated to be lower than 9 years, while in the second case, the Carnot battery is not able to provide a gain. Eventually, the influence of some parameters, such as the photovoltaic power plant surface, the storage volume, the electricity price profile and the reversible heat pump/organic Rankine cycle specific investment cost, on the techno-economic performance of the system, is investigated through a wide sensitivity analysis. According to the results, the photovoltaic panels surface does not significantly affect the economic gain, while the storage capacity strongly affects the system scheduling and the operating costs. Indeed, it is possible to identify that 13 m3 is the size of the storage volume that minimizes the payback period to 8.22 years, for the considered application. An increase in the electricity price without an increase in the thermal energy price leads to a decrease in economic gain because the benefit brought by the downsizing of district heating is less significant on the economic balance. The specific investment cost of the reversible heat pump/organic Rankine cycle does not influence the operating cost; thus, it does not change the Carnot battery management, nor the economic gain. The specific investment cost affects the payback period, which increases from 8.6 years for a specific cost of 2000 €/kWe to 15.7 years for a specific cost of 5000 €/kWe
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Dynamics of long gas bubbles rising in a vertical tube in a cocurrent liquid flow
© 2019 American Physical Society. When a confined long gas bubble rises in a vertical tube in a cocurrent liquid flow, its translational velocity is the result of both buoyancy and mean motion of the liquid. A thin film of liquid is formed on the tube wall and its thickness is determined by the interplay of viscous, inertial, capillary and buoyancy effects, as defined by the values of the Bond number (Bo≡ρgR2/σ with ρ being the liquid density, g the gravitational acceleration, R the tube radius, and σ the surface tension), capillary number (Cab≡μUb/σ with Ub being the bubble velocity and μ the liquid dynamic viscosity), and Reynolds number (Reb≡2ρUbR/μ). We perform experiments and numerical simulations to investigate systematically the effect of buoyancy (Bo=0-5) on the shape and velocity of the bubble and on the thickness of the liquid film for Cab=10-3-10-1 and Reb=10-2-103. A theoretical model, based on an extension of Bretherton's lubrication theory, is developed and utilized for parametric analyses; its predictions compare well with the experimental and numerical data. This study shows that buoyancy effects on bubbles rising in a cocurrent liquid flow make the liquid film thicker and the bubble rise faster, when compared to the negligible gravity case. In particular, gravitational forces impact considerably the bubble dynamics already when B
CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS
No abstract available
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