Chemo-dynamical Evolution of the ISM in Galaxies

Chemo-dynamical models have been introduced in the late eighties and are a generally accepted tool for understanding galaxy evolution. They have been successfully applied to one-dimensional problems, e.g. the evolution of non-rotating galaxies, and two-dimensional problems, e.g. the evolution of disk galaxies. Recently, also three-dimensional chemo-dynamical models have become available. In these models the dynamics of different components, i.e. dark matter, stars and a multi-phase interstellar medium, are treated in a self-consistent way and several processes allow for an exchange of matter, energy and momentum between the components or different gas phases. Some results of chemo-dynamical models and their comparison with observations of chemical abundances or star formation histories will be reviewed.Comment: 10 Pages, 5 Figures, to appear in "From Observations to Self-Consistent Modelling of the ISM in Galaxies", 2003, eds M. Avillez et a

Early evolution of Tidal Dwarf Galaxies

Our aim is to study the evolution of tidal dwarf galaxies. The first step is to understand whether a model galaxy without Dark Matter can sustain the feedback of the ongoing star formation. We present tests of the evolution of models in which star formation efficiency, temperature threshold, initial distribution of gas and infall are varied. We conclude that it is feasible to keep a fraction of gas bound for several hundreds of Myr and that the development of galactic winds does not necessarily stop continuous star formation.Comment: 2 pages, 1 figure, to appear in the Proceedings of the CRAL conference "Chemodynamics: from first stars to local galaxies", Lyon, France, 10-14 July 200

Counteracting systems of diabaticities using DRAG controls: The status after 10 years

The task of controlling a quantum system under time and bandwidth limitations is made difficult by unwanted excitations of spectrally neighboring energy levels. In this article we review the Derivative Removal by Adiabatic Gate (DRAG) framework. DRAG is a multi-transition variant of counterdiabatic driving, where multiple low-lying gapped states in an adiabatic evolution can be avoided simultaneously, greatly reducing operation times compared to the adiabatic limit. In its essence, the method corresponds to a convergent version of the superadiabatic expansion where multiple counterdiabaticity conditions can be met simultaneously. When transitions are strongly crowded, the system of equations can instead be favorably solved by an average Hamiltonian (Magnus) expansion, suggesting the use of additional sideband control. We give some examples of common systems where DRAG and variants thereof can be applied to improve performance.Comment: 7 pages, 2 figure

Instanton Solutions for the Universal Hypermultiplet

We expand our previous analysis on fivebrane and membrane instanton solutions in the universal hypermultiplet, including near-extremal multi-centered solutions and mixed fivebrane-membrane charged instantons. The results are most conveniently described in terms of a double-tensor multiplet.Comment: Minor changes, clarification added. Contribution to the proceedings of the 36th International Symposium Ahrenshoop, August 200

Disc-protoplanet interaction Influence of circumprimary radiative discs on self-gravitating protoplanetary bodies in binary star systems

Context. More than 60 planets have been discovered so far in systems that harbour two stars, some of which have binary semi-major axes as small as 20 au. It is well known that the formation of planets in such systems is strongly influenced by the stellar components, since the protoplanetary disc and the particles within are exposed to the gravitational influence of the binary. However, the question on how self-gravitating protoplanetary bodies affect the evolution of a radiative, circumprimary disc is still open. Aims. We present our 2D hydrodynamical GPU-CPU code and study the interaction of several thousands of self-gravitating particles with a viscous and radiative circumprimary disc within a binary star system. To our knowledge this program is the only one at the moment that is capable to handle this many particles and to calculate their influence on each other and on the disc. Methods. We performed hydrodynamical simulations of a circumstellar disc assuming the binary system to be coplanar. Our gridbased staggered mesh code relies on ideas from ZEUS-2D, where we implemented the FARGO algorithm and an additional energy equation for the radiative cooling according to opacity tables. To treat particle motion we used a parallelised version of the precise Bulirsch - Stoer algorithm. Four models in total where computed taking into account (i) only N-body interaction, (ii) N-body and disc interaction, (iii) the influence of computational parameters (especially smoothing) on N-body interaction, and (iv) the influence of a quiet low-eccentricity disc while running model (ii). The impact velocities where measured at two different time intervals and were compared. Results. We show that the combination of disc- and N-body self-gravity can have a significant influence on the orbit evolution of roughly Moon sized protoplanets

Long-term follow-up of 22 psoriatic patients treated with ixekizumab after failure of secukinumab

Switching of biologic agents in treatment of plaque psoriasis is a common strategy. Only a few studies are available on switching between IL17A-blockers. In a retrospective study, we identified 22 psoriasis patients who, after failing secukinumab as a first IL17A-blocker received ixekizumab with an observation period of at least 24 weeks. At last observation 10/22 patients had a good response (PASI75 or PASI<3) using ixekizumab therapy. None of five patients with primary non-response to secukinumab reached a good, durable response to ixekizumab. In conclusion, ixekizumab appears to be a therapeutic option as a second IL17A-blocker in psoriasis patients who did not show a primary non-response to secukinumab