VITAMIN B1PROMOTED GREEN SYNTHESIS OF BENZOFURAN CHALCONES: PROMISING SCAFFOLDS FOR DRUG DEVELOPMENT IN ANTIMICROBIAL

 Objective: To develop metal free and environmentally benign synthetic method for the synthesis of chalcones bearing benzofuran scaffolds. Materials and Methods:Starting material chloroacetone,anhydrous potassium carbonate, different aromatic aldehydes, ethanol and vitamin B1 of AR grade wereused for synthesis.Various chalcones were synthesized byClaisen-Schmidt condensation.The structure of the synthesized compounds was confirmed by elemental analysis, IR,1H NMR and mass spectra.  Results:In this context we have tried new metal free and environmentally benign synthetic method for synthesis of the pharmaceutically important molecule 1-(4-substituted-1-benzofuran-2-yl) substituted chalcones and its derivatives and it was screened for their antimicrobial activity.Most of the compounds exhibited the good to moderate activity. Conclusion:Herein we have tried a highly efficient protocol for the synthesis of chalconesa good result with variety of functionalities, a high yield of products, and the recoverability of this catalyst.Vitamin B1 as a catalyst has been developed using green solvent EtOH

A clinical study to evaluate the efficacy of Khaakhasadi Lepa in Padadari (Crack Heel)

Padadari = Pada + Dari. Padadari is one among Kshudra Rogas. Sushruta, Madhavnidana and Bhavprakasha has explained Padadari as distinct disease. In modern, it is termed as crack heel. Padadari is a Vatapradhana Vyadhi. Vataprakopa leads to the symptoms as Padasputana, Vedana, Rukshata and Daha. Atichankramana and Vataprakopaka Ahara and Vihara are the main cause for Padadari. Khaakhasadi Lepa has Vatahara, Vranashodhaka, Vranaropaka, Twagdoshahara, Kandughna properties which helps in Samprapti Vighatana of Padadari. The study is attempt to clinically analyze the efficacy of Khakhasadi Lepa indendently and compare with Moisturex cream in Padadari. This study is a randomized single blind standared control clinical study conducted on 60 subjects divided randomly in two groups. Group A (Trial group) and Group B (Control group) were formed with 30 patients in each group. Group A was treated with Khaakhasadi Lepa for one month. Group B was treated with Moisturex cream for one month. Lepa was adviced to apply in night on affected area of sole in quantity sufficient. Cleaning of sole and after proper drying, application of lepa was advised.The patients were assessed with severity of symptoms subjectively before and after treatment. Data from each group is statistically analyzed and compared. Both the group showed marked results but Khaakhasadi Lepa showed statistically highly significant result in subjective parameter like Vedana and Rukshata. Khakhasadi Lepa is not that much significant in Padasputana as compare to Moisturex cream. The study shows that Khaakhasadi Lepa and Moisturex cream had got equally significant relief in Vedana and Rukshata. Both drugs were insignificant in reducing Daha. Khakhasadi Lepa was not more effective in Padasputana

Best Practices at BVDU’ S AKIMSS Library: A case study

This paper gives idea about the different best practices adopted by institutions in management and administration of the library system. An effective management of library supports excellence in library services which helps in the good service to the library visitors. The different types of material is available in the library such as reference books, text books, periodicals magazines, yearbooks, annual reports which are very useful to the students in different aspects. Best practices in library which follows different theories to give the visitors the good, quick & fast service. In academic libraries, librarians use the various procedures as exhibitions of new arrivals, user orientation programs etc

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR ESTIMATION OF ABACAVIR IN TABLET DOSAGE FORM

Objective: To develop and validate simple, rapid, linear, accurate, precise and economical UV Spectroscopic method for estimation of Abacavir in tablet dosage form. Methods: The drug is freely soluble in analytical grade methanol. The drug was identified in terms of solubility studies and on the basis of melting point done on the melting point apparatus of Equiptronics. It showed absorption maxima were determined in analytical grade methanol. The drug obeyed the Beer’s law and showed good correlation of concentration with absorption, which reflect in linearity. The UV spectroscopic method was developed for estimation of Abacavir in tablet dosage form and also validated as per ICH guidelines. Results: The drug is freely soluble in analytical grade methanol, slightly soluble in water and practically insoluble in ethanol. So, the analytical grade methanol is used as a diluent in method. The melting point of Abacavir was found to be 164-165 ˚C (uncorrected). It showed absorption maxima 256 nm in analytical grade methanol. On the basis of absorption spectrum the working concentration was set on 15µg/ml (PPM). The linearity was observed between 5-25 μg/ml (PPM). The results of analysis were validated by recovery studies. The recovery was found to be 98.75, 101 and 99.17% for three levels respectively. The % RSD for precision was found to be 0.32% and for Ruggedness is 0.46% Conclusion: A simple, rapid, linear, accurate, precise and economical UV Spectroscopic method has been developed for estimation of Abacavir in tablet dosage form. The method could be considered for the determination of Abacavir in quality control laboratories

Clinico-pathological study of oesophageal cancer: a 3 years retrospective and 1½ year’s prospective analysis

Background: In India, oesophageal cancer is second most common cancer among males and fourth most common among females and is associated with certain diets and lifestyle. In India, the age-adjusted incidence rates for oesophageal cancer are the highest in men (25.5) and women (5.5) in Mizoram. Aim of the study was to find the clinical and histopathological findings of oesophageal cancer patients at Civil Hospital, Aizawl.Methods: A descriptive study (3 years retrospective and 1½ years prospective) was conducted at Civil Hospital, Aizawl, Mizoram from July 2013 to December 2014 (1½ years) amongst 104 patients reporting to Civil Hospital, Aizawl for oesophageal cancer.Results: History of progressive dysphagia to solids was most common symptom and observed in 91.3% patients. Histopathological examination of resected esophageal specimen showed 95.7% patients were detected with squamous cell carcinoma, 4.3% patients were detected with no proper malignancy/residual tumor.Conclusion: Squamous-cell carcinoma was the most common type of esophageal cancer occurring in the middle third of the oesophagus with as observed on upper gastrointestinal (GI) endoscopy. More men were affected than female.

Bioactive Components of Magical Velvet Beans

The plant Mucuna is an annual climbing shrub with long vines that can reach over fifteen meters in length. About 100–150 Mucuna species are found in the tropic and subtropic regions of both hemispheres of the earth. The genus Mucuna belongs to the family Leguminosae. It is commonly known as Kewanch, velvet bean, cowhage and kappikachhu and is found widely in India as a hardy, herbaceous, vigorous, twining annual plant. The size and dimension of the Mucuna seeds, pods, platelets and leaves change from species to species. The hair present on pods is anthelmintic, which causes itching. People are seeking great attention towards Mucuna due to its several medicinal properties, including L-DOPA (L-3, 4-dihydroxyphenylalanine) along with supplementary antioxidants that are used for treating Parkinson’s disease and many neurodegenerative diseases. Thus it is being used in about 200 medicinal formulations. The current chapter outlines the work that determines the influence of different nutritional, anti-nutritional and medicinal values and bioactive agents from different parts of the Mucuna species present in India and its importance in medicine

Onychomycosis: dermatophytes to yeasts: an experience in and around Mumbai, Maharashtra, India

Background: Onychomycosis is a fungal nail infection having wide range of prevalence in different geographical regions. It becomes imperative to know prevalent causative agent in local area to improve quality of life of patients. Present study was aimed to study epidemiological, clinical and laboratory aspects of onychomycosisMethods: Study was carried out prospectively at a tertiary care teaching hospital Nail scrapings of 630 clinically suspected cases of onychomycosis over a period of 5 years (January 2012 to December 2016) were subjected to KOH examination and culture.Results: Young adults in age group of 21-40 years (67.61%) were predominantly affected with male to female ratio of 1.8:1. Overall prevalence of onychomycosis of the present study is 58.41%. Yeasts were isolated in 47.86%, dermatophytes in 30.71% and non dermatophytic filamentous fungi in 21.43%Conclusions: Present study demonstrates a shift in causative agents from dermatophytes to yeasts.

Novel synthesis of D-ribo-[2S,3S,4R]-2-N-palmitoyl-2-aminoheptadecane-1,3,4-triol

205-20

Electronic Waste (E-Waste) Management Strategies By Household In Solapur City

The use of electronic equipments in the society is highly increasing. Need of the electronic equipments, economically suitable and easy to handle these are the main factors that increases the demand of electronic components. Without electronic equipment the man cannot walk a single foot. Due to the huge utilization of the electronic equipment in the day-to-day life it increases in the generation of e-waste. Because of large amount of e-waste it will be harmful for the environment and human health. The electronic equipments which are mostly used in the house are television set, refrigerator, grinder, music system, radio, electricity components, mobile phones, computers etc. The findings show that the preferred methods of electronic waste disposal by Solapur city residents are storage and sale as second-hand equipment, is about 21% and 26% respectively. Only a fraction of electronic waste (10%) finds its way to recycling facilities as there is no efficient take-back scheme for consumers. Most of the households do not know where and how to dispose of electronic waste in a proper manner.  In this research article the researcher is going to identify the practices by household about e-waste management in the Solapur city