Histological evidence of wound healing improvement in rats treated with oral administration of hydroalcoholic extract of Vitis labrusca

Plant extracts rich in phenolic compounds have been demonstrated to accelerate wound healing, but their use by oral route has been poorly studied. The leaves of Vitis labrusca are rich in phenolic acids and flavonoids. The goal of this study was to assess the healing properties of the oral administration of hydroalcoholic extract of V. labrusca leaves (HEVL) in a murine model. HEVL was obtained by Soxhlet and dynamic maceration, and their yield and phenolic acids and flavonoid contents were determined. For the wound healing assay, 8 mm wounds were performed on the back of 48 Wistar rats, assigned into four groups (n=12): CTR (distilled water), HEVL100, HEVL200, and HEVL300 (HEVL at 100, 200, and 300 mg/kg, respectively). On days 7 and 14, wound closure rates were assessed, and the healing wounds were subjected to histological analysis. Soxhlet-obtained extract was selected for the wound healing assay because it provided a higher yield and phenolic acid and flavonoid contents. HEVL significantly reduced leukocytosis in the peripheral blood (p < 0.05), accelerated wound closure (p < 0.05), and improved collagenization (p < 0.05) on day 7, as well as enhanced the epidermal tissue thickness (p < 0.001) and elastic fiber deposition on day 14 (p < 0.01). Furthermore, HEVL promoted an increase in the histological grading of wound healing on both days 7 and 14 (p < 0.01). The doses of 200 and 300 mg/kg provided better results than 100 mg/Kg. Our data provide histological evidence that the oral administration of HEVL improves wound healing in rodents. Therefore, the extract can be a potential oral medicine for healing purposes.Brazilian Council for Research Support (CNPq) and the Foundation of research and technological innovation of Sergipe/Brazil (FAPITEC), and by the Portuguese Science and Technology Foundation (FCT/MCT), European Funds (PRODER/COMPETE)– project UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020info:eu-repo/semantics/publishedVersio

Projeto piloto para disseminar o conceito de propriedade intelectual: aplicado nas bibliotecas da Universidade Eestadual de Santa Ccruz e da Universidade Estadual de Feira de Santana, situadas na Bahia-Brasil

Buscando a inovação e ampliação dos serviços oferecidos às bibliotecas da Universidade Estadual de Feira de Santana e a Universidade Estadual de Santa Cruz, estão em fase de desenvolvimento de um projeto piloto que tem como objetivo disseminar o conceito de propriedade intelectual. Este apresentará uma metodologia ativa e participativa, tanto dos ministrantes do curso, assim como do público alvo. Para desenvolver o mesmo, formar-se-á uma equipe por profissionais a qual serão capacitadas e auxiliadas pelo Núcleo de Inovação Tecnológica (NIT).Seeking to innovate and expand the services offered to the libraries of the State University of Feira de Santana and the Santa Cruz State University, they are in the process of developing a pilot project that aims to disseminate the concept of intellectual property. This will present an active and participative methodology, both of the course's attendees, as well as the target audience. To develop the same, a team will be formed by professionals who will be trained and assisted by the Nucleus of Technological Innovation (NIT).Ibero-American Science and Technology Education Consortiu

Projeto piloto para disseminar o conceito de propriedade intelectual: aplicado nas bibliotecas da Universidade Eestadual de Santa Ccruz e da Universidade Estadual de Feira de Santana, situadas na Bahia-Brasil

Buscando a inovação e ampliação dos serviços oferecidos às bibliotecas da Universidade Estadual de Feira de Santana e a Universidade Estadual de Santa Cruz, estão em fase de desenvolvimento de um projeto piloto que tem como objetivo disseminar o conceito de propriedade intelectual. Este apresentará uma metodologia ativa e participativa, tanto dos ministrantes do curso, assim como do público alvo. Para desenvolver o mesmo, formar-se-á uma equipe por profissionais a qual serão capacitadas e auxiliadas pelo Núcleo de Inovação Tecnológica (NIT).Seeking to innovate and expand the services offered to the libraries of the State University of Feira de Santana and the Santa Cruz State University, they are in the process of developing a pilot project that aims to disseminate the concept of intellectual property. This will present an active and participative methodology, both of the course's attendees, as well as the target audience. To develop the same, a team will be formed by professionals who will be trained and assisted by the Nucleus of Technological Innovation (NIT).Ibero-American Science and Technology Education Consortiu

Projeto piloto para disseminar o conceito de propriedade intelectual: aplicado nas bibliotecas da Universidade Eestadual de Santa Ccruz e da Universidade Estadual de Feira de Santana, situadas na Bahia-Brasil

Buscando a inovação e ampliação dos serviços oferecidos às bibliotecas da Universidade Estadual de Feira de Santana e a Universidade Estadual de Santa Cruz, estão em fase de desenvolvimento de um projeto piloto que tem como objetivo disseminar o conceito de propriedade intelectual. Este apresentará uma metodologia ativa e participativa, tanto dos ministrantes do curso, assim como do público alvo. Para desenvolver o mesmo, formar-se-á uma equipe por profissionais a qual serão capacitadas e auxiliadas pelo Núcleo de Inovação Tecnológica (NIT).Seeking to innovate and expand the services offered to the libraries of the State University of Feira de Santana and the Santa Cruz State University, they are in the process of developing a pilot project that aims to disseminate the concept of intellectual property. This will present an active and participative methodology, both of the course's attendees, as well as the target audience. To develop the same, a team will be formed by professionals who will be trained and assisted by the Nucleus of Technological Innovation (NIT).Ibero-American Science and Technology Education Consortiu

Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study

Background- Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients. Objective- Evaluate whether blood cell count parameters may serve as predictors for malaria treatment. Methodology- A cross-sectional study with a quantitative approach. Results- Of the 219 patients, 21.5% showed failure to antimalarial treatment, Patient with 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), with high parasitemia (59.8%), treated with Arthemeter (90.9%) and the mortality were 5.9%. Significant associations were observed between occupation, level of parasitemia and outcome with resistance to antimalarial treatment (p<0.05). Patients with normal Hb [OR: 0.75 (95% CI: 0.39–1.44), p = 0.393], RBC [OR: 0.83 (95% CI: 0.40–1.72), p = 0.632], RDW [OR: 0.54 (95% CI: 0.27–1.09), p = 0.088], MCV [OR: 0.61 (95% CI: 0.28–1.31), p = 0.204] were less likely to have malaria treatment failures after artemisinin-based therapy failure. In contrast, those with normal values of segmented neutrophils [OR: 0.32 (95% CI: 0.11–0.96), p = 0.042] and lymphocyte counts [OR: 0.24 (95% CI: 0.05–1.04), p = 0.055]. We also found that patients with significant low levels of Hct [OR: 0.31 (95% CI: 0.15–0.64) p = 0.002], and high leukocytes [OR: 8.88 (95% CI: 2.02–37.2), p = 0.004] and normal platelet values [OR: 1.42 (95% CI: 0.73–2.95), p = 0.280] demonstrated high probability of treatment failure. Conclusion- The importance of blood cell count parameters in monitoring malaria therapy necessitates the urgent need to re-evaluate Artemether-based therapy. Future studies involving more participants in different settings are needed to provide further evidence

Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes

Paracoccidioidomycosis is a mycotic disease caused by a dimorphic fungus, Paracoccidioides brasiliensis (Pb), that starts with inhalation of the fungus; thus, lung cells such as DC are part of the first line of defense against this microorganism. Migration of DC to the lymph nodes is the first step in initiating T cell responses. The mechanisms involved in resistance to Pb infection are poorly understood, but it is likely that DC play a pivotal role in the induction of effector T cells that control Pb infection. In this study, we showed that after Pb Infection, an important modification of lung DC receptor expression occurred. We observed an increased expression of CCR7 and CD103 on lung DC after infection, as well as MHC-II. After Pb infection, bone marrow-derived DC as well lung DC, migrate to lymph nodes. Migration of lung DC could represent an important mechanism of pathogenesis during PCM infection. In resume our data showed that Pb induced DC migration. Furthermore, we demonstrated that bone marrow-derived DC stimulated by Pb migrate to the lymph nodes and activate a T helper (Th) response. To the best of our knowledge, this is the first reported data showing that Pb induces migration of DC and activate a T helper (Th) response